苯环己乙胺 | 3590-16-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 苯环己乙胺
• 中文别名: 非克立明
• 英文名称: tetra-N-ethyl-2-(cyclohexyl-phenyl-methyl)-propanediyldiamine
• 英文别名: Tetra-N-aethyl-2-(cyclohexyl-phenyl-methyl)-propandiyldiamin；feclemine；2-[cyclohexyl(phenyl)methyl]-N,N,N',N'-tetraethylpropane-1,3-diamine
• CAS: 3590-16-7
• 化学式: C₂₄H₄₂N₂
• 分子量: 358.611
• InChiKey: QDMORDTWFMWOFA-UHFFFAOYSA-N

物化性质

• 沸点：
  450.7±38.0 °C(Predicted)
• 密度：
  0.938±0.06 g/cm3(Predicted)
• 保留指数：
  2250;2275;2213

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  26
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2921590090

文献信息

• Technology for the Preparation of Microparticles
  申请人：Malakhov Michael

  公开号：US20090098207A1

  公开（公告）日：2009-04-16

  Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals, nutraceuticals, cosmetic products and the like of defined dimensions.

  微球是通过将溶液中的大分子或小分子与抗溶剂和对离子接触，并冷却溶液而制备的。这些微球可用于制备具有明确定义尺寸的药物、营养保健品、化妆品等产品。
• Thiazolidinone, oxazolidinone, and imidazolone derivatives for treating non-inflammatory gastrointestinal tract disorders
  申请人：Fraser Oliver Matthew

  公开号：US20050113421A1

  公开（公告）日：2005-05-26

  A method is provided for using Cav2.2 subunit calcium channel modulators, particularly thiazolidinone, oxazolidinone, and imidazolone derivatives, to treat non-inflammatory gastrointestinal tract disorders.

  提供了一种方法，用于使用Cav2.2亚单位钙通道调节剂，特别是噻唑啉酮、噁唑啉酮和咪唑啉酮衍生物，来治疗非炎症性胃肠道疾病。
• Bioreponsive Polymers
  申请人：Laronde Frank

  公开号：US20100041771A1

  公开（公告）日：2010-02-18

  The invention features biodegradable polymers for the delivery of biologically active agents. The polymers include at least one biologically active agent covalently attached via a polyamide linker susceptible to selective hydrolysis by peptidase enzymes. Hydrolysis of the polyamide linker releases the biologically active agent in vivo.

  这项发明涉及生物活性剂的传递的可生物降解聚合物。这些聚合物包括至少一个生物活性剂，通过易受肽酶选择性水解的聚酰胺连接物共价连接。聚酰胺连接物的水解会在体内释放生物活性剂。
• Methods and compositions for the delivery of biologically active agents
  申请人：Esfand Roseita

  公开号：US20070037891A1

  公开（公告）日：2007-02-15

  The invention features polymers noncovalently complexed with a biologically active agent. The polymer complexes include at least one shielding moiety covalently tethered to at least one complexing moiety, which is complexed with at least one biologically active agent.

  该发明涉及与生物活性剂非共价配合的聚合物。聚合物复合物包括至少一个与至少一个复合基团共价连接的屏蔽基团，该复合基团与至少一个生物活性剂复合。
• Compositions and methods to effect the release profile in the transdermal administration of active agents
  申请人：——

  公开号：US20020004065A1

  公开（公告）日：2002-01-10

  Compositions and methods for the transdermal delivery of active agents up to a period of seven days or more at substantially a zero-order release rate comprising a pharmaceutically acceptable adhesive matrix and a polymeric plastic material that provides a release rate regulating effect on the active agents.

  本发明涉及一种用于经皮递送活性药剂的组合物和方法，该组合物和方法能够在持续时间为七天或更长时间内以几乎零阶释放速率递送活性药剂，包括一种药学上可接受的粘合基质和一种聚合物塑料材料，该聚合物塑料材料对活性药剂具有释放速率调节作用。