4-chloro-6-(1-fluoro-1-methyl-ethyl)-1,3,5-triazin-2-amine | 252577-14-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 4-chloro-6-(1-fluoro-1-methyl-ethyl)-1,3,5-triazin-2-amine
• 英文别名: 2-amino-4-chloro-6-(1-fluoro-1-methylethyl)-1,3,5-triazine；4-Chloro-6-(2-fluoropropan-2-yl)-1,3,5-triazin-2-amine
• CAS: 252577-14-3
• 化学式: C₆H₈ClFN₄
• mdl: MFCD20694747
• 分子量: 190.608
• InChiKey: QLGAUXJYKAVRNE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  64.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-chloro-6-(1-fluoro-1-methyl-ethyl)-1,3,5-triazin-2-amine 在 ammonium hydroxide 、 sodium hydride 作用下， 以 1,4-二氧六环 、 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 反应 0.5h， 生成 N4-(4-chloro-2,5-difluoro-6-methyl-3-pyridyl)-6-(1-fluoro-1-methylethyl)-1,3,5-triazine-2,4-diamine
  参考文献：
  名称：

  [EN] HERBICIDAL AZINES
  [FR] AZINES HERBICIDES

  摘要：

  本发明涉及公式（I）的二氨基三嗪化合物及其作为除草剂的用途。本发明还涉及用于作物保护的农药组合物以及一种控制不受欢迎的植被的方法，其中所有变量如权利要求书1中所定义，包括其农业上可接受的盐。

  公开号：

  WO2018166822A1
• 作为产物：
  描述：

  4-(2-氟丙烷-2-基)-6-(甲硫基)-1,3,5-三嗪-2-胺 在 氯 、 溶剂黄146 作用下， 以67.4%的产率得到4-chloro-6-(1-fluoro-1-methyl-ethyl)-1,3,5-triazin-2-amine
  参考文献：
  名称：

  [EN] HERBICIDAL COMBINATION COMPRISING AZINES
  [FR] COMBINAISON HERBICIDE COMPRENANT DES AZINES

  摘要：

  本发明涉及除草剂组合物，其中包括至少一种式(I)的化合物（成分a），以及至少一种从具有除草活性的化合物（成分b）和/或安全剂（成分c）中选择的进一步化合物，其中Ra、Rb、Rc、Rd等为H、卤素、CN、NO2、C1-C6-烷基、C1-C6-卤代烷基、OH、C1-C6-烷氧基、C1-C6-烷基硫基等；R1等为H、OH、S（O）2NH2、CN、C1-C6-烷基等；R2等为H、卤素、CN、C1-C6-烷基、C1-C6-卤代烷基、C2-C6-烯基、C3-C6-炔基等；R3等为H、卤素、CN、C1-C6-烷基等；R4等为H、卤素、CN、C1-C6-烷基等；或者R3和R4与它们连接的碳原子一起形成从羰基、C2-C6-烯基、C3-C6-环烷基、C3-C6-环烯基和三至六元杂环烷基中选择的基团；R5等为H、OH、S（O）2NH2、CN、C1-C6-烷基等；包括它们的农业上可接受的盐或N-氧化物；以及至少一种从除草剂化合物b）和安全剂c）中选择的进一步化合物以及它们的混合物。

  公开号：

  WO2015162164A1

文献信息

• Alkylamino-1,3,5-triazines, processes for their preparation and their use as herbicides and plant growth regulators
  申请人：——

  公开号：US20030224942A1

  公开（公告）日：2003-12-04

  2,4-Diamino-1,3,5-triazines, process for their preparation and their use as herbicides and plant growth regulators, Compounds of the formula (I) and salts thereof 1 where R 1 is (C 1 -C 10 )alkyl, (C 3 -C 6 )cycloalkyl, (C 1 -C 10 )alkoxy or (C 1 -C 10 )alkylthio, optionally halogenated and in the case of cyclic radicals optionally also substituted by (C 1 -C 6 )alkyl and (C 1 -C 6 )haloalkyl; R 2 and R 3 are H, (C 1 -C 4 )alkyl, CHO or [(C 1 -C 10 )alkyl]carbonyl, optionally halogenated; R 4 is hydrogen, (C 1 -C 10 )alkyl, (C 2 -C 10 )alkenyl, (C 2 -C 10 )alkynyl or (C 3 -C 6 )cycloalkyl, where each of the 4 last-mentioned radicals is unsubstituted or halogenated and in the case of cyclic radicals optionally substituted by (C 1 -C 6 )alkyl and (C 1 -C 6 )haloalkyl; R 4 is hydrogen, (C 1 -C 10 )alkyl, (C 2 -C 10 )alkenyl, (C 2 -C 10 )alkynyl or (C 3 -C 6 )cycloalkyl, where each of the 4 last-mentioned radicals is unsubstituted or substituted by one or more radicals selected from the group consisting of halogen and in the case of cyclic radicals also (C 1 -C 6 )alkyl and (C 1 -C 6 )haloalkyl; each of the radicals R 5 , R 6 , R 7 , R 8 and R 9 independently of the others is hydrogen, halogen; nitro. cyano, thiocyanato, (C 1 -C 10 )alkyl, (C 2 -C 10 )alkenyl, (C 2 -C 10 )alkynyl, (C 1 -C 10 )alkoxy, (C 2 -C 10 )alkenyloxy, (C 2 -C 10 )alkynyloxy, (C 1 -C 10 )alkylthio, (C 2 -C 10 )alkenylthio, (C 2 -C 10 )alkynylthio, (C 3 -C 6 )cycloalkyl, (C 5 -C 6 )cycloalkenyl, phenyl or heterocyclyl, where each of the 13 last-mentioned radicals is unsubstituted or substituted, where at least one of the radicals from the group consisting of R 5 , R 6 , R 7 , R 8 and R 9 is different from hydrogen and where at least one of the radicals R 5 , R 6 , R 7 , R 8 and R 9 is selected from the group consisting of the radicals (C 2 -C 10 )alkenyl, (C 2 -C 10 )alkynyl, (C 3 -C 6 )cycloalkyl and (C 5 -C 6 )cycloalkenyl, where each of the 4 last-mentioned radicals is unsubstituted or substituted, are suitable for use as herbicides and plant growth regulators. The compounds (I) can be prepared by the process claimed in claim 6.

  2,4-二氨基-1,3,5-三嗪，其制备方法及其作为除草剂和植物生长调节剂的用途。具有以下结构式（I）的化合物及其盐，其中R1为（C1-C10）烷基，（C3-C6）环烷基，（C1-C10）烷氧基或（C1-C10）硫代烷基，可选择卤代，对于环状基团，还可选择由（C1-C6）烷基和（C1-C6）卤代烷基取代；R2和R3为H，（C1-C4）烷基，CHO或[（C1-C10）烷基]羰基，可选择卤代；R4为氢，（C1-C10）烷基，（C2-C10）烯基，（C2-C10）炔基或（C3-C6）环烷基，其中上述4种基团均未取代或卤代，对于环状基团，还可选择由（C1-C6）烷基和（C1-C6）卤代烷基取代；每个基团R5、R6、R7、R8和R9独立地为氢，卤素，硝基，氰基，硫氰基，（C1-C10）烷基，（C2-C10）烯基，（C2-C10）炔基，（C1-C10）烷氧基，（C2-C10）烯氧基，（C2-C10）炔氧基，（C1-C10）硫代烷基，（C2-C10）烯基硫代基，（C2-C10）炔基硫代基，（C3-C6）环烷基，（C5-C6）环烯基，苯基或杂环基，其中上述13种基团均未取代或取代，其中来自R5、R6、R7、R8和R9基团组的至少一个基团不同于氢，并且来自R5、R6、R7、R8和R9基团中至少一个基团选择自（C2-C10）烯基，（C2-C10）炔基，（C3-C6）环烷基和（C5-C6）环烯基的基团组，其中上述4种基团均未取代或取代，适用于作为除草剂和植物生长调节剂。化合物（I）可以通过第6项权利要求中所述的方法制备。
• 2,4 diamino-1,3,5-triazines, processes for their preparation and their use as herbicides and plant growth regulators
  申请人：——

  公开号：US20040034222A1

  公开（公告）日：2004-02-19

  Compounds of the formula (I) or salts thereof 1 in which R 1 =(subst.)aryl, (subst.)(C 3 -C 9 )cycloalkyl, (subst.)heterocyclyl, (subst.)(C 1 -C 6 )alkyl, (subst.)(C 2 -C 6 )alkenyl or (subst.)(C 2 -C 6 )alkynyl, R 2 =a (subst.)carbocycle having 4 to 6 ring atoms, (subst.)heterocycle having 3 to 6 ring atoms and 1 to 4 heteroatoms N, O and S, or the formula —A—Z, in which A=straight-chain unsubst. or subst. (C 1 -C 4 )alkylene, (C 2 -C 5 )alkenylene or (C 2 -C 5 )alkynylene, and Z=(subst.)carbocycle having 3-6 ring atoms, (subst.)heterocycle having 3-6 ring atoms and 1-4-heteroatoms N, O and S, R 3 =H, (subst.)(C 1 -C 6 )alkyl, (subst.)aryl or (subst.)(C 3 -C 9 )cycloalkyl, or a radical of the formula —N(B 1 —D 1 )(B 2 —D 2 ) or —NR′—N(B 1 —D 1 )(B 2 —D 2 ), in which B 1 , B 2 , D 1 and D 2 are as defined below, and R′=H, (C 1 -C 6 )alkyl or [(C 1 -C 4 )alkyl]carbonyl, R 4 =—B 3 —D 3 , where B 3 and D 3 are as defined below, B 1 , B 2 and B 3 =a direct bond or —C(═Z*)—, —C(═Z*)—Z**—, —C(═Z*)—NH— or —C(═Z*)—NR*—, where Z*, Z**=O, S and R*=(C 1 -C 6 )alkyl, aryl, aryl-(C 1 -C 6 )alkyl, (C 3 -C 9 )cycloalkyl or (C 3 -C 9 )cycloalkyl-(C 1 -C 6 )alkyl, each case opt. subst., D 1 , D 2 , D 3 =H, (C 1 -C 6 )alkyl, aryl, aryl-(C 1 -C 6 )alkyl, (C 3 -C 9 )cycloalkyl or (C 3 -C 9 )cycloalkyl-(C 1 -C 6 )alkyl, in each case opt. substituted, and (X) n are substituents as defined in more detail in claim 1 and n=0-5, are suitable for use as herbicides and plant growth regulators.

  式(I)的化合物或其盐，其中R1=(取代)芳基、(取代)(C3-C9)环烷基、(取代)杂环基、(取代)(C1-C6)烷基、(取代)(C2-C6)烯基或(取代)(C2-C6)炔基，R2=具有4至6个环原子的(取代)碳环、具有3至6个环原子和1至4个杂原子N、O和S的(取代)杂环，或式—A—Z，其中A=直链未取代或取代(C1-C4)烷基、(C2-C5)烯基或(C2-C5)炔基，Z=具有3-6个环原子的(取代)碳环、具有3-6个环原子和1-4个杂原子N、O和S的(取代)杂环，R3=H、(取代)(C1-C6)烷基、(取代)芳基或(取代)(C3-C9)环烷基，或式—N(B1—D1)(B2—D2)或—NR′—N(B1—D1)(B2—D2)的基团，其中B1、B2、D1和D2如下所定义，R′=H、(C1-C6)烷基或[(C1-C4)烷基]羰基，R4=—B3—D3，其中B3和D3如下定义，B1、B2和B3=直接键或—C(═Z*)—、—C(═Z*)—Z**—、—C(═Z*)—NH—或—C(═Z*)—NR*—，其中Z*、Z**=O、S和R*=(C1-C6)烷基、芳基、芳基-(C1-C6)烷基、(C3-C9)环烷基或(C3-C9)环烷基-(C1-C6)烷基，每种情况下均可选择取代基，D1、D2、D3=H、(取代)(C1-C6)烷基、(取代)芳基、(取代)芳基-(C1-C6)烷基、(取代)(C3-C9)环烷基或(取代)(C3-C9)环烷基-(C1-C6)烷基，每种情况下均可选择取代基，(X)n为声明1中更详细定义的取代基，n=0-5，适用于作为除草剂和植物生长调节剂。
• Process for the preparation of 2-amino-4-chloro-1,3,5-triazines
  申请人：Aventis CropScience GmbH

  公开号：US07002011B1

  公开（公告）日：2006-02-21

  Compounds of the formula (I) or salts thereof are suitable for preparing active substances from the from the class of the aminotriazines of the formula (IV), for example herbicidal active substances. The compounds (I) can be prepared by chlorinating compounds of the formula (II) where, in the formulae, R1, R2, R3 and X are as defined in claim 1 and A and R have the meaning required in the active substances to be prepared, and they can be reacted with amines of the formula A—NH—R to give the active substances.

  公式（I）的化合物或其盐适用于制备公式（IV）的氨基三嗪类活性物质，例如除草剂活性物质。化合物（I）可以通过氯化公式（II）的化合物制备，其中，在公式中，R1、R2、R3和X的定义如权利要求书中所定义，A和R具有所需的活性物质中所需的含义，并且它们可以与公式A-NH-R的胺反应以给出活性物质。
• Substituted 2,4-diamino-1,3,5-triazines, processes for their preparation and their use as herbicides and plant growth regulators
  申请人：——

  公开号：US20010011063A1

  公开（公告）日：2001-08-02

  Compounds of the formula (I) and salts thereof in optically active form, 1 in which R 1 , R 2 , R 3 , R 4 , A, X and n are as defined in claim 1, are suitable for use as herbicides and plant growth regulators. The compounds (I) can be prepared by processes according to claim 7 via intermediates, some of which are novel, for example of the formulae (III) and (V).

  公式（I）及其光学活性盐化合物，其中R1、R2、R3、R4、A、X和n的定义如权利要求书1所述，适用于用作除草剂和植物生长调节剂。化合物（I）可以通过权利要求书7所述的过程制备，其中包括一些新的中间体，例如公式（III）和（V）。
• 2,4-diamino-1,3,5-triazines, their preparation, and their use as herbicides and plant growth regulators
  申请人：——

  公开号：US20020091260A1

  公开（公告）日：2002-07-11

  The invention is in the technical field of the crop protection agents, such as herbicides and plant growth regulators, in particular of the herbicides for the selective control of harmful plants in crops of useful plants.

  这项发明属于作物保护剂技术领域，例如除草剂和植物生长调节剂，特别是针对有用植物作物中有害植物的选择性控制除草剂。