2-(1,3-benzoxazol-2-yl)-3H-benzo[f]chromen-3-one | 71860-31-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: 2-(1,3-benzoxazol-2-yl)-3H-benzo[f]chromen-3-one
• 英文别名: 3-(benzoxazol-2-yl)benzo[5,6]coumarin；2-benzooxazol-2-yl-benzo[f]chromen-3-one；2-(1,3-benzoxazol-2-yl)benzo[f]chromen-3-one
• CAS: 71860-31-6
• 化学式: C₂₀H₁₁NO₃
• 分子量: 313.312
• InChiKey: IGQLBIZUYPZOGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  52.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-imino-3H-benzo[f]chromene-2-carboxamide 、 2-氨基苯酚 以 正丁醇 为溶剂， 以71%的产率得到2-(1,3-benzoxazol-2-yl)-3H-benzo[f]chromen-3-one
  参考文献：
  名称：

  Recyclization of 2-imino-2H-1-benzopyrans using nucleophilic reagents 3. Reaction of 2-iminocoumarin-3-carboxamides with o-phenylenediamines and o-amino(thio)phenols

  摘要：

  DOI：

  10.1007/bf02317811

文献信息

• Synthesis, Photo- and Electro-Luminescence of 3-Benzoxazol-2-yl-Coumarin Derivatives
  作者：Yuling Zhao、Tianzhi Yu、Youzhi Wu、Hui Zhang、Duowang Fan、Zunwei Gan、Liangliang Yang、Xiaoqian Han、Yumei Zhang

  DOI：10.1007/s10895-011-0999-8

  日期：2012.3

  Two coumarin derivatives containing electron-transporting benzoxazolyl moiety, 7-(diethylamino)-3-(benzoxazol-2-yl)coumarin (DABOC) and 3-(benzoxazol-2-yl)benzo[5,6]coumarin (BOBC), were synthesized and characterized. The photoluminescence and electroluminescence of the compounds were investigated detailedly. The compounds exhibited strong blue-green emissions in both solution and solid states, but the devices with DABOC as the emitting layer exhibited orange emission and maximum luminous efficiency of 2.8 cd/A and maximum luminance of 8,800 cd/m2, and the devices with BOBC displayed orange-white emission and maximum luminous efficiency of 0.13 cd/A and maximum luminance of 540 cd/m2.

  合成并表征了两种含有电子传递苯并恶唑基的香豆素衍生物，即 7-(二乙基氨基)-3-(苯并恶唑-2-基)香豆素（DABOC）和 3-(苯并恶唑-2-基)苯并[5,6]香豆素（BOBC）。对这些化合物的光致发光和电致发光进行了详细研究。这些化合物在溶液和固体状态下都表现出强烈的蓝绿色发射，但以 DABOC 为发射层的器件表现出橙色发射，最大发光效率为 2.8 cd/A 和最大亮度为 8,800 cd/m2 ；而以 BOBC 为发射层的器件则表现出橙白色发射，最大发光效率为 0.13 cd/A 和最大亮度为 540 cd/m2 。
• Derivatives of chromen-2-one as inhibitors of vegf production in mammalian cells
  申请人：Menta Ernesto

  公开号：US20060122387A1

  公开（公告）日：2006-06-08

  The compounds of formula (I) wherein A and R1-R5 are as defined in the description, are inhibitors of Vascular Endothelial Growth Factor and are useful as angiogenesis inhibitors and antiproliferative agents.

  式(I)中的化合物，其中A和R1-R5如描述中所定义，是血管内皮生长因子的抑制剂，可用作抗血管生成剂和抗增殖剂。
• POLYMERIZABLE LIQUID CRYSTAL COMPOSITION, POLARIZED LIGHT-EMITTING COATING MATERIAL, NOVEL NAPHTHOLACTAM DERIVATIVE NOVEL COUMARIN DERIVATIVE, NOVEL NILE RED DERIVATIVE, AND NOVEL ANTHRACENE DERIVATIVE
  申请人：Kubota Yusuke

  公开号：US20130334461A1

  公开（公告）日：2013-12-19

  Provided are a polymerizable liquid crystal composition, a coating material, a medium, and a polarizing device each produced using a polymerizable liquid crystal compound and a colorant and each capable of producing polarized light suitable for polarizing devices, and also a novel naphtholactam derivative, a novel coumarin derivative, a novel Nile Red derivative, and a novel anthracene derivative each suitable for use as the colorant. Specifically provided are a polymerizable liquid crystal composition containing (A) at least one liquid crystal compound having a polymerizable functional group, (B) at least one colorant, and (C) a polymerization initiator, and a novel naphtholactam derivative of formula (IV′), a novel coumarin derivative of formula (VI′), a novel Nile Red derivative of formula (VII′), and a novel anthracene derivative of formula (VIII′) each suitable for use as the colorant (B).

  提供了一种可聚合的液晶组合物、涂料材料、介质和极化装置，每种都使用了聚合液晶化合物和颜料，并且能够产生适合于极化装置的偏振光，还提供了一种新型萘内酰胺衍生物、一种新型香豆素衍生物、一种新型尼罗红衍生物和一种新型蒽衍生物，每种都适用于用作颜料。具体提供了一种聚合液晶组合物，包含（A）至少一种具有聚合功能基团的液晶化合物，（B）至少一种颜料，和（C）聚合引发剂，以及一种适用于用作颜料（B）的新型萘内酰胺衍生物（IV′）, 一种新型香豆素衍生物（VI′）, 一种新型尼罗红衍生物（VII′）和一种新型蒽衍生物（VIII′）。
• Methods and compositions for inhibiting mutant EGFR signaling
  申请人：The Governing Council of the University of Toronto

  公开号：US11123330B2

  公开（公告）日：2021-09-21

  Methods of inhibiting mutant EGFR and methods of treating a subject afflicted with a lung cancer having a mutant EGFR, having for example a C797 mutation, are described. The methods comprise administering to a cell or a subject in need thereof a therapeutically effective amount of a compound selected from 3-(1,3-benzoxazol-2-yl)-7-(diethylamino)-2H-chromen-2-one and a structurally related analog thereof; midostaurin; and AZD7622 and a structurally related analog thereof; and mixtures thereof. Compositions and combinations comprising the compounds of the disclosure as well as uses are also provided.

  本发明描述了抑制突变表皮生长因子受体的方法和治疗具有突变表皮生长因子受体（例如具有C797突变）的肺癌患者的方法。这些方法包括向细胞或有需要的受试者施用治疗有效量的选自3-(1,3-苯并恶唑-2-基)-7-(二乙氨基)-2H-色烯-2-酮及其结构相关类似物、米多司他林、AZD7622及其结构相关类似物和它们的混合物的化合物。还提供了包含本公开化合物的组合物和组合物以及用途。
• Joseph,K.U.; Somayajulu,V.V., Journal of the Indian Chemical Society, 1979, vol. 56, p. 505 - 507
  作者：Joseph,K.U.、Somayajulu,V.V.

  DOI：——

  日期：——