4-methyl-3,5-dihydro-2H-1,4-benzothiazepine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并硫氮卓类
• 英文名称: 4-methyl-3,5-dihydro-2H-1,4-benzothiazepine
• 化学式: C₁₀H₁₃NS
• 分子量: 179.28
• InChiKey: QOBDCAOCLDYQFS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  28.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• PROCESS FOR PREPARING BENZOTHIAZEPINES FROM GAMMA-AMINOALKYLBENZENES
  申请人：Deng Shixian

  公开号：US20090227788A1

  公开（公告）日：2009-09-10

  The invention provides a process for preparing a 2,3,4,5-tetrahydro[1,4]benzothiazepine of formula: by reacting a [2-(acylaminoethyl)thio]arene of formula with an aldehyde or a multimer thereof, and with an acid. The invention also provides for first reacting the [2-(acylaminoethyl)thio]arene with the aldehyde or multimer thereof and a base to form an [N-hydroxymethyl-2-[acylaminoethyl)thio]arene of formula then treating the [N-hydroxymethyl-2-(acylaminoethyl)thio]arene with the acid to form the 2,3,4,5-tetrahydro[1,4]benzothiazepine.

  该发明提供了一种制备2,3,4,5-四氢[1,4]苯并噻吩的方法，通过将式中的[2-(酰胺基乙基)硫]芳烃与醛或其多聚物以及酸反应。该发明还提供了首先将[2-(酰胺基乙基)硫]芳烃与醛或其多聚物以及碱反应以形成式的[N-羟甲基-2-(酰胺基乙基)硫]芳烃，然后用酸处理[N-羟甲基-2-(酰胺基乙基)硫]芳烃以形成2,3,4,5-四氢[1,4]苯并噻吩。
• METHODS FOR SYNTHESIZING BENZOTHIAZEPINE COMPOUNDS
  申请人：Landry Donald W.

  公开号：US20090292119A1

  公开（公告）日：2009-11-26

  The present invention provides improved methods for synthesizing novel benzothiazepine compounds. In particular, the invention relates to a new method that generally is used to make the substituted 2,3,4,5-tetrahydro-1,4-benzothiazepine compounds of a general formula which then may be used to make many other benzothiazepine compounds.

  本发明提供了改进的合成新型苯并噻吩化合物的方法。具体来说，本发明涉及一种新方法，通常用于制备一般式的取代2,3,4,5-四氢-1,4-苯并噻吩化合物，然后可以用于制备许多其他苯并噻吩化合物。
• Agents for preventing and treating disorders involving modulation of the RyR receptors
  申请人：The Trustees of Columbia University in the City of New York

  公开号：EP2177224A2

  公开（公告）日：2010-04-21

  The present invention provides compounds of Formula I, (I) and salts, hydrates, solvates, complexes, and prodrugs thereof. The present invention further provides methods for synthesizing compounds of Formula I. The invention additionally provides pharmaceutical compositions comprising the compounds of Formula I and methods of using the pharmaceutical compositions of Formula I to treat and prevent disorders and diseases associated with the RyR receptors that regulate calcium channel functioning in cells.

  本发明提供了式I、(I)化合物及其盐类、水合物、溶质、络合物和原药。本发明进一步提供了合成式 I 化合物的方法。本发明还提供了包含式I化合物的药物组合物，以及使用式I药物组合物治疗和预防与调节细胞中钙离子通道功能的RyR受体有关的紊乱和疾病的方法。
• Agents for preventing and treating disorders involving modulation of the ryr receptors
  申请人：The Trustees of Columbia University in the City of New York

  公开号：EP2311464A1

  公开（公告）日：2011-04-20

  The present invention provides compounds of Formula I, (I) and salts, hydrates, solvates, complexes, and prodrugs thereof. The present invention further provides methods for synthesizing compounds of Formula I. The invention additionally provides pharmaceutical compositions comprising the compounds of Formula I and methods of using the pharmaceutical compositions of Formula I to treat and prevent disorders and diseases associated with the RyR receptors that regulate calcium channel functioning in cells.

  本发明提供了式I、(I)化合物及其盐类、水合物、溶质、络合物和原药。本发明进一步提供了合成式 I 化合物的方法。本发明还提供了包含式I化合物的药物组合物，以及使用式I药物组合物治疗和预防与调节细胞中钙离子通道功能的RyR受体有关的紊乱和疾病的方法。
• [EN] AGENTS FOR PREVENTING AND TREATING DISORDERS INVOLVING MODULATION OF THE RYR RECEPTORS<br/>[FR] AGENTS PERMETTANT DE PREVENIR ET DE TRAITER DES TROUBLES ENTRAINANT LA MODULATION DES RECEPTEURS RYR
  申请人：UNIV COLUMBIA

  公开号：WO2007024717A2

  公开（公告）日：2007-03-01

  [EN] The present invention provides compounds of Formula I, (I) and salts, hydrates, solvates, complexes, and prodrugs thereof. The present invention further provides methods for synthesizing compounds of Formula I. The invention additionally provides pharmaceutical compositions comprising the compounds of Formula I and methods of using the pharmaceutical compositions of Formula I to treat and prevent disorders and diseases associated with the RyR receptors that regulate calcium channel functioning in cells.
  [FR] Cette invention concerne des composés représentés par la formule I, (I) ainsi que des sels, des hydrates, des solvates, des complexes, et des promédicaments associés. Cette invention concerne également des méthodes permettant des synthétiser les composés représentés par la formule I. En outre, cette invention concerne des compositions pharmaceutiques comprenant les composés représentés par la formule I afin de prévenir et de traiter des troubles et des maladies associées aux récepteurs RyR qui régulent la fonction du canal calcique dans les cellules.