(R)-2-Amino-1-(5-chloro-benzooxazol-2-yl)-4-phenyl-butan-1-ol | 233690-62-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶唑类
• 英文名称: (R)-2-Amino-1-(5-chloro-benzooxazol-2-yl)-4-phenyl-butan-1-ol
• 英文别名: (1r)-1-[(Rs)-(5-chloro-2-benzoxazolyl)hydroxymethyl]-3-phenylpropylamine；(2R)-2-amino-1-(5-chloro-1,3-benzoxazol-2-yl)-4-phenylbutan-1-ol
• CAS: 233690-62-5
• 化学式: C₁₇H₁₇ClN₂O₂
• 分子量: 316.787
• InChiKey: BUCFKFNACVCTCI-JBZHPUCOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  72.3
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (R)-2-Amino-1-(5-chloro-benzooxazol-2-yl)-4-phenyl-butan-1-ol 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 生成 (R)-2,5-Diamino-pentanoic acid {(R)-1-[(5-chloro-benzooxazol-2-yl)-hydroxy-methyl]-3-phenyl-propyl}-amide; compound with trifluoro-acetic acid
  参考文献：
  名称：

  Peptidomimetics of Efflux Pump Inhibitors Potentiate the Activity of Levofloxacin in Pseudomonas aeruginosa

  摘要：

  Several classes of peptidomimetics of the efflux pump inhibitor D-ornithine-D-homophenylalanine-3-aminoquinoline (MC-02,595) have been prepared and evaluated for their ability to potentiate the activity of the fluoroquinolone levofloxacin in Pseudomonas aeruginosa. A number of the new analogues were as active or more active than the lead. demonstrating that a peptide backbone is not essential for activity. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00006-9
• 作为产物：
  描述：

  (3R)-N-tert-Butoxycarbonyl-5-phenyl-3-amino-2-hydroxypentanonitrile 在 乙酰氯 、 三氟乙酸 作用下， 以 乙醇 、 二氯甲烷 、 氯仿 为溶剂， 生成 (R)-2-Amino-1-(5-chloro-benzooxazol-2-yl)-4-phenyl-butan-1-ol
  参考文献：
  名称：

  Peptidomimetics of Efflux Pump Inhibitors Potentiate the Activity of Levofloxacin in Pseudomonas aeruginosa

  摘要：

  Several classes of peptidomimetics of the efflux pump inhibitor D-ornithine-D-homophenylalanine-3-aminoquinoline (MC-02,595) have been prepared and evaluated for their ability to potentiate the activity of the fluoroquinolone levofloxacin in Pseudomonas aeruginosa. A number of the new analogues were as active or more active than the lead. demonstrating that a peptide backbone is not essential for activity. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00006-9

文献信息

• Peptidomimetic efflux pump inhibitors
  申请人：Essential Therapeutics, Inc.

  公开号：US06436980B1

  公开（公告）日：2002-08-20

  Compounds are described which have efflux pump inhibitor activity. Also described are methods of using such efflux pump inhibitor compounds and pharmaceutical compositions which include such compounds.

  描述了具有外排泵抑制剂活性的化合物。还描述了使用这种外排泵抑制剂化合物的方法和包括这种化合物的药物组成物。
• US6204279B1
  申请人：——

  公开号：US6204279B1

  公开（公告）日：2001-03-20
• US6436980B1
  申请人：——

  公开号：US6436980B1

  公开（公告）日：2002-08-20
• Peptidomimetics of Efflux Pump Inhibitors Potentiate the Activity of Levofloxacin in Pseudomonas aeruginosa
  作者：Thomas E. Renau、Roger Léger、Rose Yen、Miles W. She、Eric M. Flamme、Joan Sangalang、Carla L. Gannon、Suzanne Chamberland、Olga Lomovskaya、Ving J. Lee

  DOI：10.1016/s0960-894x(02)00006-9

  日期：2002.3

  Several classes of peptidomimetics of the efflux pump inhibitor D-ornithine-D-homophenylalanine-3-aminoquinoline (MC-02,595) have been prepared and evaluated for their ability to potentiate the activity of the fluoroquinolone levofloxacin in Pseudomonas aeruginosa. A number of the new analogues were as active or more active than the lead. demonstrating that a peptide backbone is not essential for activity. (C) 2002 Elsevier Science Ltd. All rights reserved.