N,N-dimethylpropan-1-olamine | 13948-35-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N-dimethylpropan-1-olamine
• 英文别名: N,N-dimethylaminopropanol；dimethylaminopropanol；1-dimethylaminopropanol；N-dimethylaminopropanol；N,N-Dimethylaminopropan-1-ol；dimethylamino-propan-1-ol；1-(Dimethylamino)propan-1-ol
• CAS: 13948-35-1
• 化学式: C₅H₁₃NO
• 分子量: 103.164
• InChiKey: SUZOCIFIGKCISE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N-dimethylpropan-1-olamine 、 4-(4-Hydroxyphenyl)-N-(3,4,5-trimethoxyphenyl)-2-pyrimidineamine 、 偶氮二甲酸二乙酯 在 三苯基膦 作用下， 生成 4-(4-(3-N,N-Dimethylaminopropoxy)phenyl)-N-(3,4,5-trimethoxyphenyl)-2-pyrimidineamine
  参考文献：
  名称：

  US5958935

  摘要：

  公开号：

文献信息

• Pheophorbide derivatives
  申请人：Hamari Chemicals, Ltd.

  公开号：US04965064A1

  公开（公告）日：1990-10-23

  Novel pheophorbide derivatives of the general formula: ##STR1## [wherein Z is O or NH; n is an integer of 1 to 6; Y is NR'R" or ##STR2## wherein R', R" and R'" are the same or different or each represents a C.sub.1 to C.sub.4 lower alkyl group; X.sup.- is a halogen or organic acid ion); R.sub.1 is an ethenyl group; C.sub.1 to C.sub.4 lower alkyl group or ##STR3## (wherein m is an integer of 0 to 6; R.sub.6 is H or a C.sub.1 to C.sub.4 lower alkyl group); R.sub.2 is CH.sub.3, CHO or CH.sub.2 OH; either of R.sub.3 and R.sub.4 is H, with the other being OH, or both of them combine to represent .dbd.O; R.sub.5 is H or CO.sub.2 CH.sub.3) are provided. When administered to a cancer-carrying animal, the derivatives accumulate specifically in cancer tissues and emit characteristic fluorescent spectrum under irradiation of light, which enables one to detect the cancer tissues.

  一种新的苊类衍生物的一般公式为：##STR1## [其中Z为O或NH；n为1到6的整数；Y为NR'R"或##STR2## 其中R'、R"和R'"相同或不同，或每个代表C.sub.1到C.sub.4的低碳链基；X.sup.-为卤素或有机酸根离子）；R.sub.1为乙烯基；C.sub.1到C.sub.4的低碳链基或##STR3## （其中m为0到6的整数；R.sub.6为H或C.sub.1到C.sub.4的低碳链基）；R.sub.2为CH.sub.3、CHO或CH.sub.2 OH；R.sub.3和R.sub.4中的任意一个为H，另一个为OH，或两者结合表示.dbd.O；R.sub.5为H或CO.sub.2 CH.sub.3）。当这些衍生物被用于治疗患有癌症的动物时，它们会特异性地积累在癌组织中，并在光照射下发出特征性的荧光光谱，从而使人们能够检测到癌组织。
• Quaternary amine containing ether or ester lipid derivatives and
  申请人：Wake Forest University

  公开号：US05614548A1

  公开（公告）日：1997-03-25

  Quaternary amine-containing ether lipid analogs of the formula R.sub.1 --X--R.sub.2 --N.sup.+ (R.sub.3) (R.sub.4) (R.sub.5) Z.sup.- are disclosed. R.sub.1 represents a hydrophobic group and R.sub.2 represents the backbone of the molecule, with the quaternary amine being linked directly to the backbone. Pharmaceutical compositions including these compounds and methods of combating tumors with these compounds are disclosed. Also disclosed is a method of combating viral infections with both these compounds and ET-18-OMe and its analogs.

  公开了式子为R.sub.1 -X-R.sub.2 -N.sup.+ (R.sub.3) (R.sub.4) (R.sub.5) Z.sup.-的四元胺含有醚脂类似物。R.sub.1代表疏水基团，R.sub.2代表分子的骨架，四元胺直接连接到骨架上。公开了包括这些化合物的制药组合物和使用这些化合物对抗肿瘤的方法。还公开了使用这些化合物和ET-18-OMe及其类似物对抗病毒感染的方法。
• Fiber surface modifiers
  申请人：Allied-Signal Inc.

  公开号：US04939289A1

  公开（公告）日：1990-07-03

  This invention relates to fiber surface treating agents containing a pyromellitate nucleus which have fungicidal, anti-microbial and anti-static properties, and blends of such agents with other types of surface modifiers.

  这项发明涉及含有苯四酸酐核的纤维表面处理剂，具有杀菌、抗微生物和抗静电性能，以及该类剂与其他类型表面改性剂的混合物。
• Epoxy resin with aminomethylene groups
  申请人：BASF Lacke + Farben Aktiengesellschaft

  公开号：US05283269A1

  公开（公告）日：1994-02-01

  Epoxy resins with urethane groups, containing on average per molecule from 0.5 to 5 groups of the formula I ##STR1## where the substituents R.sup.1 and R.sup.2 are C.sub.1 -C.sub.8 -alkyl groups, which may also be linked together to form five- or six-membered rings, which may contain an oxygen atom, or are each phenyl, are useful in electrocoating.

  含有脲基的环氧树脂，每个分子平均含有0.5到5个公式I的基团##STR1##其中取代基R1和R2是C1-C8烷基，它们也可以连接在一起形成五元或六元环，其中可能包含一个氧原子，或者它们各自是苯基，这些环氧树脂在电泳涂装中有用。
• 5-arylpyrimidines as anticancer agents
  申请人：Zhang Nan

  公开号：US20050075357A1

  公开（公告）日：2005-04-07

  This invention relates to certain 5-arylpyrimidine compounds or a pharmaceutically acceptable salt thereof, and compositions containing said compounds or a pharmaceutically acceptable salt thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals. This invention further relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and further provides a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or a pharmaceutically acceptable salt thereof. More specifically, the present invention relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof by promotion of microtubule polymerization which comprises administering to said mammal an effective amount of said compounds and pharmaceutically acceptable salts thereof.

  本发明涉及某些5-芳基嘧啶化合物或其药学上可接受的盐，以及含有该化合物或其药学上可接受的盐的组合物，其中该化合物是一种抗癌剂，可用于哺乳动物的癌症治疗。本发明还涉及一种治疗或抑制哺乳动物中癌细胞肿瘤生长和相关疾病的方法，并进一步提供了一种治疗或预防多药耐药性（MDR）表达多种药物抗性的癌症肿瘤的方法，该方法包括向所述哺乳动物中注射有效量的该化合物或其药学上可接受的盐。更具体地，本发明涉及一种通过促进微管聚合来治疗或抑制哺乳动物中需要治疗或抑制癌细胞肿瘤生长和相关疾病的方法，该方法包括向所述哺乳动物中注射有效量的该化合物及其药学上可接受的盐。