2-Isobutyroylaminopyrimidine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-Isobutyroylaminopyrimidine
• 英文别名: 2-methyl-N-pyrimidin-2-ylpropanamide
• 化学式: C₈H₁₁N₃O
• 分子量: 165.19
• InChiKey: MDRUNTRSGGUUIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  54.9
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Raf inhibitor compounds and methods of use thereof
  申请人：Miknis Greg

  公开号：US20070049603A1

  公开（公告）日：2007-03-01

  Compounds of Formula I are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

  公式I的化合物对抑制Raf激酶和治疗由此介导的疾病有用。公开了使用公式I的化合物及其立体异构体、几何异构体、互变异构体、溶剂合物和药学上可接受的盐，在哺乳动物细胞中进行体外、体内和体内诊断、预防或治疗此类疾病或相关病理条件的方法。
• Novel beta-adrenergic agonists
  申请人：Merck & Co., Inc.

  公开号：EP0318092A2

  公开（公告）日：1989-05-31

  There are disclosed certain α-heterocyclic ethanolamine derivatives wherein the amine is substituted with various alkyl, alkenyl or alkynyl groups optionally substituted with hydroxy or alkoxy groups. The compounds are potent β-agonists and are thus useful as growth promotion agents for animals. Compositions for such uses are also disclosed.

  公开了某些α-杂环乙醇胺衍生物，其中的胺被各种烷基、烯基或炔基取代，可选择被羟基或烷氧基取代。这些化合物是强效的 β-兴奋剂，因此可用作动物的生长促进剂。还公开了用于此类用途的组合物。
• SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS
  申请人：GlaxoSmithKline Intellectual Property (No.2) Limited

  公开号：US20170355705A1

  公开（公告）日：2017-12-14

  The present invention relates to novel substituted bridged urea analog compounds of Formula (I) or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, processes for making and use of such compounds, alone or in combination with other therapeutic agents, as Sirtuin Modulators useful for increasing lifespan of a cell, and for use in treating and/or preventing a wide variety of diseases and disorders, which include, but are not limited to, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity.