1,2,3,4-tetrahydroquinolizinium iodide | 129355-40-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹嗪类
• 英文名称: 1,2,3,4-tetrahydroquinolizinium iodide
• 英文别名: 1,2,3,4-tetrahydroquinolizin-5-ium;iodide
• CAS: 129355-40-4
• 化学式: C₉H₁₂N*I
• 分子量: 261.105
• InChiKey: KHEBIHDSMYDKEF-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.69
• 重原子数：
  11.0
• 可旋转键数：
  0.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  3.88
• 氢给体数：
  0.0
• 氢受体数：
  0.0

反应信息

• 作为反应物：
  描述：

  1,2,3,4-tetrahydroquinolizinium iodide 、 3-ethyl-4,5-dihydro-5-(3-methyl-2(3H)-benzothiazolylidene)-2-methylthioxo-4-thiazolium p-toluenesulfonate 在 三乙胺 、 Amberlyte IRA-400 作用下， 以 乙腈 为溶剂， 以59%的产率得到1-[3-Ethyl-5-[3-methyl-3H-benzothiazol-(2E)-ylidene]-4-oxo-thiazolidin-(2Z)-ylidene]-1,2,3,4-tetrahydro-quinolizinylium; chloride
  参考文献：
  名称：

  Syntheses and Biological Activities of Structurally Stiff Rhodacyanines as Novel Antimalarial Candidates

  摘要：

  New classes of rhodacyanine as structurally stiff derivatives were designed and synthesized. The synthetic compounds were evaluated the antimalarial activity and cytotoxicity in vitro.

  DOI：

  10.3987/com-05-s(k)67
• 作为产物：
  描述：

  4-(2-吡啶基)正丁醇 在 咪唑 、 碘 、 三苯基膦 作用下， 以 甲苯 为溶剂， 以59%的产率得到1,2,3,4-tetrahydroquinolizinium iodide
  参考文献：
  名称：

  Syntheses and Biological Activities of Structurally Stiff Rhodacyanines as Novel Antimalarial Candidates

  摘要：

  New classes of rhodacyanine as structurally stiff derivatives were designed and synthesized. The synthetic compounds were evaluated the antimalarial activity and cytotoxicity in vitro.

  DOI：

  10.3987/com-05-s(k)67

文献信息

• Intramolecular free-radical substitution of pyridinium rings
  作者：John A. Murphy、Michael S. Sherburn

  DOI：10.1016/s0040-4020(01)86445-0

  日期：1991.1

  Intramolecular free radical substitution of pyridinium salts has been accomplished giving good yields of [6,5]-, [6,6]- and [6,7]-bicyclic compounds.

  吡啶鎓盐的分子内自由基取代已经完成，得到了[6,5]-，[6,6]-和[6,7]双环化合物的良好收率。
• Intramolecular addition of Free radicals to quaternised heterocyclic rings.
  作者：John A. Murphy、Michael S. Sherburn

  DOI：10.1016/0040-4039(90)80034-j

  日期：1990.1

  The intramolecular addition of free radicals to quaternary pyridinium salts gives good yields of tetrahydroquinolizinium salts.

  自由基在季吡啶鎓盐中的分子内加成产生良好的四氢喹啉鎓鎓盐收率。
• MURPHY, JOHN A.;SHERBURN, MICHAEL S., TETRAHEDRON. LETT., 31,(1990) N1, C. 1625-1628
  作者：MURPHY, JOHN A.、SHERBURN, MICHAEL S.

  DOI：——

  日期：——
• MURPHY, JOHN A.;SHERBURN, MICHAEL S.;DICKINSON, JULIA M.;GOODMAN, CHRIS, J. CHEM. SOC. CHEM. COMMUN.,(1990) N6, C. 1069-1070
  作者：MURPHY, JOHN A.、SHERBURN, MICHAEL S.、DICKINSON, JULIA M.、GOODMAN, CHRIS

  DOI：——

  日期：——
• Syntheses and Biological Activities of Structurally Stiff Rhodacyanines as Novel Antimalarial Candidates
  作者：Kiyosei Takasu、Masataka Ihara、Daiki Morisaki、Marcel Kaiser、Reto Brun

  DOI：10.3987/com-05-s(k)67

  日期：——

  New classes of rhodacyanine as structurally stiff derivatives were designed and synthesized. The synthetic compounds were evaluated the antimalarial activity and cytotoxicity in vitro.