(2R,4S)-2-Ethyl-4-fluoro-[1,3]oxathiolan-5-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧硫杂环戊烷
• 英文名称: (2R,4S)-2-Ethyl-4-fluoro-[1,3]oxathiolan-5-one
• 英文别名: (2R,4S)-2-ethyl-4-fluoro-1,3-oxathiolan-5-one
• 化学式: C₅H₇FO₂S
• 分子量: 150.174
• InChiKey: ZLOSAPAETOTYJA-DMTCNVIQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  51.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-Ethyl-[1,3]oxathiolan-5-one 在 四乙基氟化铵水合物 作用下， 以 乙腈 为溶剂， 生成 (2R,4S)-2-Ethyl-4-fluoro-[1,3]oxathiolan-5-one 、 (2R,4R)-2-Ethyl-4-fluoro-[1,3]oxathiolan-5-one
  参考文献：
  名称：

  Electrolytic Partial Fluorination of Organic Compounds. 30.¹ Drastic Improvement of Anodic Monofluorination of 2-Substituted 1,3-Oxathiolan-5-ones Using the Novel Fluorine Source Et₄NF·4HF

  摘要：

  The highly regioselective anodic monofluorination of 2-substituted 1,3-oxathiolan-5-ones was successfully carried out using a novel supporting electrolyte, Et4NF . 4HF, while use of a conventional supporting electrolyte, Et3N . 3HF, resulted in no formation or extremely low yields of the fluorinated products.

  DOI：

  10.1021/jo981437g

文献信息

• Electrolytic Partial Fluorination of Organic Compounds. 30.¹ Drastic Improvement of Anodic Monofluorination of 2-Substituted 1,3-Oxathiolan-5-ones Using the Novel Fluorine Source Et₄NF·4HF
  作者：Seiichiro Higashiya、Satoru Narizuka、Akinori Konno、Tomoko Maeda、Kunitaka Momota、Toshio Fuchigami

  DOI：10.1021/jo981437g

  日期：1999.1.1

  The highly regioselective anodic monofluorination of 2-substituted 1,3-oxathiolan-5-ones was successfully carried out using a novel supporting electrolyte, Et4NF . 4HF, while use of a conventional supporting electrolyte, Et3N . 3HF, resulted in no formation or extremely low yields of the fluorinated products.