N-(2-羟基乙基)胍盐酸盐 | 63885-25-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N-(2-羟基乙基)胍盐酸盐
• 中文别名: N-(2-羟基-乙基)-胍; 盐酸盐
• 英文名称: 2-guanidinoethanol hydrochloride
• 英文别名: Guanidine, hydroxyethyl-, hydrochloride；diaminomethylidene(2-hydroxyethyl)azanium;chloride
• CAS: 63885-25-6
• 化学式: C₃H₉N₃O*ClH
• 分子量: 139.585
• InChiKey: AGGLIVUFWZNXEL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.33
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  84.6
• 氢给体数：
  4
• 氢受体数：
  2

安全信息

• 海关编码：
  2925290090

反应信息

• 作为反应物：
  描述：

  N-(2-羟基乙基)胍盐酸盐 在 硫酸 作用下， 生成 2-Guanidinoethyl-sulfat
  参考文献：
  名称：

  取代的烷基和烷氧基胍的合成及其降血糖活性。

  摘要：

  DOI：

  10.1021/jm00295a016
• 作为产物：
  描述：

  N-(1-ethanol-2-yl)-2-amino-4,6-dimethoxypyrimidine 在 盐酸 作用下， 以 水 为溶剂， 反应 12.0h， 以45%的产率得到N-(2-羟基乙基)胍盐酸盐
  参考文献：
  名称：

  Using N-substituted-2-amino-4,6-dimethoxypyrimidines in the synthesis of aliphatic guanidines

  摘要：

  The use of 2-chloro-4,6-dimethoxypyrimdine as a tool for the syntheses of substituted guanidines is presented. This method, that we had previously shown to be very useful for aromatic amines, introduces an atom economical, cost effective and environmentally functionality in aliphatic primary and secondary amin safe method for the installation of the guanidine (C) 2015 Elsevier Ltd. All rights reserved.d

  DOI：

  10.1016/j.tetlet.2015.07.007

文献信息

• Ultrasound-assisted synthesis of substituted guanidines using 1H-pyrazole-1-carboxamidine and S-methylisothiouronium sulfate under solvent-free conditions
  作者：Mitsue Fujita、Yoshio Furusho

  DOI：10.1016/j.tet.2018.06.057

  日期：2018.8

  We have investigated ultrasound-assisted synthesis of guanidine derivatives using 1H-Pyrazole-1-carboxamidine (PyzCA) and S-substituted isothiouronium sulfate (MeITU). The guanylations of several amines are promoted by ultrasound sonication under solvent-free conditions, and proceed under mild conditions. It is of particular interest that the guanylations do not require bases in most cases.

  我们已经研究了超声辅助使用1 H-吡唑-1-羧am（PyzCA）和S取代的异硫脲硫酸盐（MeITU）合成胍衍生物。在无溶剂的条件下，通过超声处理促进几种胺的鸟苷酸化，并在温和的条件下进行。特别令人感兴趣的是，在大多数情况下，鸟苷化不需要碱。
• Neuromuscular blocking agents. Replacement of quaternary ammonium groups in bis-onium compounds by amidinium, guanidinium, thiouronium, sulphonium and sulphoxonium groups
  作者：D G Bamford、D F Biggs、P Chaplen、M Davis

  DOI：10.1111/j.2042-7158.1970.tb08402.x

  日期：2011.4.12

  The quaternary ammonium groups of suxamethonium have been replaced by amidinium, guanidinium and thiouronium groups. The guanidine compound exhibited competitive neuromuscular activity of a low order of potency; the other compounds were ineffective. Replacement of the quaternary ammonium groups in decamethonium by ethylmethylsulphonium or dimethylsulphoxonium groups gave less potent, depolarizing agents.

  研究替换了琥珀胆碱的季铵基团，分别替换为酰胺基、胍基和硫脲基团。胍基化合物表现出竞争性的肌肉神经活性，但效力较低；其他化合物无效。将十甲铵中的季铵基团替换为乙基甲基磺酸铵或二甲基亚砜基团，得到效力较弱的去极化剂。
• 1H-Pyrazole-1-carboxamidine hydrochloride an attractive reagent for guanylation of amines and its application to peptide synthesis
  作者：Michael S. Bernatowicz、Youling Wu、Gary R. Matsueda

  DOI：10.1021/jo00034a059

  日期：1992.4
• Using N-substituted-2-amino-4,6-dimethoxypyrimidines in the synthesis of aliphatic guanidines
  作者：Julian W. Shaw、Laure Barbance、David H. Grayson、Isabel Rozas

  DOI：10.1016/j.tetlet.2015.07.007

  日期：2015.8

  The use of 2-chloro-4,6-dimethoxypyrimdine as a tool for the syntheses of substituted guanidines is presented. This method, that we had previously shown to be very useful for aromatic amines, introduces an atom economical, cost effective and environmentally functionality in aliphatic primary and secondary amin safe method for the installation of the guanidine (C) 2015 Elsevier Ltd. All rights reserved.d
• Synthesis and hypoglycemic activity of substituted alkyl- and alkoxyguanidines
  作者：Bernard J. Ludwig、David B. Reisner、Mervin Meyer、Leo S. Powell、Leon Simet、Frank J. Stiefel

  DOI：10.1021/jm00295a016

  日期：1970.1