N-methyl-2,3-dihydro-1,4-benzodioxine-6-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 英文名称: N-methyl-2,3-dihydro-1,4-benzodioxine-6-carboxamide
• 化学式: C₁₀H₁₁NO₃
• mdl: MFCD02713088
• 分子量: 193.2
• InChiKey: PESRFKWMHXYQSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  硝基乙烷 、 1,4-苯并二恶烷 在 polyphosphoric acid 作用下， 以10 %的产率得到N-methyl-2,3-dihydro-1,4-benzodioxine-6-carboxamide
  参考文献：
  名称：

  伯硝基烷结构和反应条件对多磷酸芳烃酰基化选择性的影响

  摘要：

  阐明了多磷酸中芳烃与硝基烷烃酰基化的机理。已经评估了多磷酸的浓度、起始化合物的结构和温度对贝克曼重排结果的影响，贝克曼重排使得反应向苯甲酰胺或苯胺转移成为可能。

  DOI：

  10.1007/s11172-024-4277-8

文献信息

• [EN] COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING NASH, NAFLD, AND OBESITY<br/>[FR] COMPOSÉS, COMPOSITIONS ET MÉTHODES DE TRAITEMENT DE LA NASH, DE LA NAFLD ET DE L'OBÉSITÉ
  申请人：LIU JINGWEN

  公开号：WO2021067490A1

  公开（公告）日：2021-04-08

  The present technology relates to methods of treating NASH, NAFLD and/or obesity using compounds of Formulas I, II, III, IV, V, and/or VI. The methods include administering to a subject suffering from one or more of non-alcoholic steatohepatitis (NASH), non- alcoholic fatty liver disease (NAFLD) and/or obesity a therapeutically effective amount of such a compound

  目前的技术涉及使用I、II、III、IV、V和/或VI式化合物治疗NASH、NAFLD和/或肥胖的方法。这些方法包括向患有非酒精性脂肪肝炎（NASH）、非酒精性脂肪肝病（NAFLD）和/或肥胖的受试者施用这种化合物的治疗有效剂量。
• Heterocyclic compounds and their use as anticancer agents
  申请人：Chen Xiaoling

  公开号：US20090318438A1

  公开（公告）日：2009-12-24

  The present invention relates to heterocyclic compounds that have anticancer activity, and pharmaceutical compositions that contain such compounds, methods of treating diseases and conditions in mammals using such compounds and composition and methods for their manufacture.

  本发明涉及具有抗癌活性的杂环化合物，以及包含这些化合物的制药组合物，使用这些化合物和组合物治疗哺乳动物的疾病和病症的方法以及它们的制造方法。
• HETEROCYCLIC COMPOUNDS AND THEIR USE AS ANTICANCER AGENTS
  申请人：Chen Xiaoling

  公开号：US20090048301A1

  公开（公告）日：2009-02-19

  The present invention relates to heterocyclic compounds that have anticancer activity, and pharmaceutical compositions that contain such compounds, methods of treating diseases and conditions in mammals using such compounds and composition and methods for their manufacture.

  本发明涉及具有抗癌活性的杂环化合物、含有这种化合物的制药组合物、使用这种化合物和组合物治疗哺乳动物疾病和病症的方法以及它们的制造方法。
• NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF
  申请人：Yokotani Junichi

  公开号：US20090105474A1

  公开（公告）日：2009-04-23

  The anthranilic acid derivative or the salt thereof represented by the general formula wherein R 1 and R 2 are hydrogen atom, or the like; R 3 is a phenyl, cycloalkyl or bicyclic heterocyclic group which may be substituted, or the like; R 4 is a phenyl, cycloalkyl or pyridyl group which may be substituted, or the like; X 1 is an alkylene or alkenylene group which may be substituted or a bond; X 2 is the general formula -X 3 -X 4 - or -X 4 -X 3 -, wherein X 3 is a sulfur atom, an imino group or a bond, or the like; X 4 means an alkylene or alkenylene group which may be substituted or a bond; is useful for a remedy such as rheumatoid arthritis, osteoarthritis and carcinoma, because it shows MMP-13 production inhibitory effect.

  该公式表示的是蒽酰氨基酸衍生物或其盐，其中R1和R2是氢原子或类似物；R3是苯基、环烷基或取代的双环杂环基团或类似物；R4是苯基、环烷基或取代的吡啶基团或类似物；X1是可取代的烷基或烯基基团或键；X2是通式-X3-X4-或-X4-X3-，其中X3是硫原子、亚胺基或键或类似物；X4是可取代的烷基或烯基基团或键。该物质对于治疗类风湿性关节炎、骨关节炎和癌症等疾病有用，因为它具有MMP-13产生抑制作用。
• PROCESS FOR SYNTHESIS OF ELIGLUSTAT AND INTERMEDIATE COMPOUNDS THEREOF
  申请人：ZHEJIANG AUSUN PHARMACEUTICAL CO., LTD.

  公开号：US20200031808A1

  公开（公告）日：2020-01-30

  The present invention relates to a process for synthesis of Eliglustat and intermediate compounds thereof. In particular, the present invention belongs to the field of synthesis of organic compounds, relates to a process for synthesis of Eliglustat and pharmaceutically acceptable salts thereof, and relates to the intermediate compounds used in the process and a process for preparation of the intermediate compounds. Compared with the existing synthetic processes, the process for preparing Eliglustat according to the present invention utilizes novel intermediates and steps for synthesis, has advantages of convenient operations, high yield, good purity of intermediates and desired product, and it is easy to apply the process in the industrial production.