[6,8-Bis(methoxymethoxy)-2,2-dimethyl-7-(3-methylbut-2-enyl)chromen-5-yl]-[2-(methoxymethoxy)-4,6-bis(phenylmethoxy)phenyl]methanol | 1134100-12-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: [6,8-Bis(methoxymethoxy)-2,2-dimethyl-7-(3-methylbut-2-enyl)chromen-5-yl]-[2-(methoxymethoxy)-4,6-bis(phenylmethoxy)phenyl]methanol
• CAS: 1134100-12-1
• 化学式: C₄₃H₅₀O₁₀
• 分子量: 726.864
• InChiKey: AOZJQVVGORQGPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.3
• 重原子数：
  53
• 可旋转键数：
  19
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  103
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  [6,8-Bis(methoxymethoxy)-2,2-dimethyl-7-(3-methylbut-2-enyl)chromen-5-yl]-[2-(methoxymethoxy)-4,6-bis(phenylmethoxy)phenyl]methanol 在 碳酸氢钠 、 戴斯-马丁氧化剂 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以80%的产率得到[6,8-Bis(methoxymethoxy)-2,2-dimethyl-7-(3-methylbut-2-enyl)chromen-5-yl]-[2-(methoxymethoxy)-4,6-bis(phenylmethoxy)phenyl]methanone
  参考文献：
  名称：

  Total synthesis of tovophyllin B

  摘要：

  The first total synthesis of tovophyllin B (2), an antimicrobial xanthone derived from mangosteen. has been accomplished through a convergent strategy from building blocks 6 and 7 involving lithium-mediated coupling, dehydrative cyclization, and 6 pi electrocyclization as key steps. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.12.096
• 作为产物：
  描述：

  4,6-dibenzyloxy-2-methoxymethyloxybenzaldehyde 、 6,8-Bis(methoxymethoxy)-2,2-dimethyl-7-(3-methylbut-2-enyl)chromene 在 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 反应 15.25h， 以58%的产率得到[6,8-Bis(methoxymethoxy)-2,2-dimethyl-7-(3-methylbut-2-enyl)chromen-5-yl]-[2-(methoxymethoxy)-4,6-bis(phenylmethoxy)phenyl]methanol
  参考文献：
  名称：

  Total synthesis of tovophyllin B

  摘要：

  The first total synthesis of tovophyllin B (2), an antimicrobial xanthone derived from mangosteen. has been accomplished through a convergent strategy from building blocks 6 and 7 involving lithium-mediated coupling, dehydrative cyclization, and 6 pi electrocyclization as key steps. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.12.096

文献信息

• Total synthesis of tovophyllin B
  作者：Valer Jeso、K.C. Nicolaou

  DOI：10.1016/j.tetlet.2008.12.096

  日期：2009.3

  The first total synthesis of tovophyllin B (2), an antimicrobial xanthone derived from mangosteen. has been accomplished through a convergent strategy from building blocks 6 and 7 involving lithium-mediated coupling, dehydrative cyclization, and 6 pi electrocyclization as key steps. (C) 2008 Elsevier Ltd. All rights reserved.