Androsta-1,4-dien-3,17-dion-17-ethylenketal | 2398-63-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Androsta-1,4-dien-3,17-dion-17-ethylenketal
• 英文别名: 17-Ethylendioxy-5-oxo-androstadien-1,4；(3aS,3bR,9aR,9bS,11aS)-9a,11a-dimethyl-2,3,3a,3b,4,5,7,9a,9b,10,11,11a-dodecahydrospiro[cyclopenta[a]phenanthrene-1,2'-[1,3]dioxolan]-7-one；(10'R,13'S)-10',13'-dimethylspiro[1,3-dioxolane-2,17'-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene]-3'-one
• CAS: 2398-63-2
• 化学式: C₂₁H₂₈O₃
• 分子量: 328.452
• InChiKey: AOYBIWCQSGSYJF-OQPPHWFISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  24
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Prostate Cancer Treatment
  申请人：Lardy A. Henry

  公开号：US20080070881A1

  公开（公告）日：2008-03-20

  The instant invention provides potent antiandrogen compounds, such as 3β-acetoxyandrost-1,5-diene-17-ethylene ketal and 3β-hydroxyandrost-1,5-diene-17-ethylene ketal, and methods for their use in the prevention and treatment of biological conditions mediated by androgen receptors. Thus, for example, compounds of the invention are useful in the prevention and treatment of prostrate cancer. Furthermore, it has been discovered that compounds of the invention are useful in the prevention and treatment of androgen-independent cancers such as androgen-independent prostrate cancer. Finally, inventive compounds may be used to treat antiandrogen induced withdrawal syndrome.

  本发明提供了强效的抗雄激素化合物，例如3β-乙酰氧基雄烯-1,5-二烯-17-乙烯基酮和3β-羟基雄烯-1,5-二烯-17-乙烯基酮，以及它们在预防和治疗由雄激素受体介导的生物状况中的使用方法。因此，例如，本发明的化合物对于预防和治疗前列腺癌非常有用。此外，发现本发明的化合物对于预防和治疗雄激素非依赖性癌症，例如雄激素非依赖性前列腺癌，也非常有用。最后，本发明的化合物可用于治疗抗雄激素引起的戒断综合征。
• Compounds and Formulations
  申请人：Lardy A. Henry

  公开号：US20080004250A1

  公开（公告）日：2008-01-03

  The instant invention provides potent antiandrogen compounds, such as 3β-acetoxyandrost-1,5-diene-17-ethylene ketal and 3β-hydroxyandrost-1,5-diene-17-ethylene ketal, and methods for their use in the prevention and treatment of biological conditions mediated by androgen receptors. Thus, for example, compounds of the invention are useful in the prevention and treatment of prostrate cancer. Furthermore, it has been discovered that compounds of the invention are useful in the prevention and treatment of androgen-independent cancers such as androgen-independent prostrate cancer. Finally, inventive compounds may be used to treat antiandrogen induced withdrawal syndrome.

  本发明提供了有效的抗雄激素化合物，例如3β-乙酰氧基雄烯-1,5-二烯-17-乙烯基醚和3β-羟基雄烯-1,5-二烯-17-乙烯基醚，及其在预防和治疗由雄激素受体介导的生物状况中的应用方法。例如，本发明的化合物在预防和治疗前列腺癌方面非常有用。此外，已经发现本发明的化合物在预防和治疗雄激素非依赖性癌症，如雄激素非依赖性前列腺癌方面非常有用。最后，本发明的化合物可用于治疗抗雄激素诱导的戒断综合症。
• Diene and Triene Compounds and Formulations
  申请人：Lardy Henry A.

  公开号：US20090181936A1

  公开（公告）日：2009-07-16

  The instant invention provides potent antiandrogen compounds, such as 3β-acetoxyandrost-1,5-diene-17-ethylene ketal and 3β-hydroxyandrost-1,5-diene-17-ethylene ketal, and methods for their use in the prevention and treatment of biological conditions mediated by androgen receptors. Thus, for example, compounds of the invention are useful in the prevention and treatment of prostrate cancer. Furthermore, it has been discovered that compounds of the invention are useful in the prevention and treatment of androgen-independent cancers such as androgen-independent prostrate cancer. Finally, inventive compounds may be used to treat antiandrogen induced withdrawal syndrome.

  本发明提供了有效的抗雄激素化合物，例如3β-乙酰氧基雄烯-1,5-二烯-17-乙烯基醚和3β-羟基雄烯-1,5-二烯-17-乙烯基醚，并提供了它们在预防和治疗由雄激素受体介导的生物病理条件中的使用方法。例如，本发明的化合物在预防和治疗前列腺癌方面是有用的。此外，发现本发明的化合物在预防和治疗雄激素非依赖性癌症，如雄激素非依赖性前列腺癌方面是有用的。最后，本发明的化合物可用于治疗抗雄激素引起的戒断综合征。
• Diene Compounds and Formulations
  申请人：Lardy Henry A.

  公开号：US20090176752A1

  公开（公告）日：2009-07-09

  The instant invention provides potent antiandrogen compounds, such as 3β-acetoxyandrost-1,5-diene-17-ethylene ketal and 3β-hydroxyandrost-1,5-diene-17-ethylene ketal, and methods for their use in the prevention and treatment of biological conditions mediated by androgen receptors. Thus, for example, compounds of the invention are useful in the prevention and treatment of prostrate cancer. Furthermore, it has been discovered that compounds of the invention are useful in the prevention and treatment of androgen-independent cancers such as androgen-independent prostrate cancer. Finally, inventive compounds may be used to treat antiandrogen induced withdrawal syndrome.

  本发明提供了强效的抗雄激素化合物，例如3β-乙酰氧基雄烯-1,5-二烯-17-乙烯基醇和3β-羟基雄烯-1,5-二烯-17-乙烯基醇，以及它们在预防和治疗由雄激素受体介导的生物状况中的使用方法。因此，例如，本发明的化合物在预防和治疗前列腺癌方面是有用的。此外，已经发现本发明的化合物在预防和治疗雄激素非依赖性癌症，如雄激素非依赖性前列腺癌方面是有用的。最后，本发明的化合物可用于治疗抗雄激素诱导的戒断综合征。
• Unsaturated Steroid Compounds
  申请人：Lardy Henry A.

  公开号：US20110028711A1

  公开（公告）日：2011-02-03

  The instant invention provides potent antiandrogen compounds, such as 3β-acetoxyandrost-1,5-diene-17-ethylene ketal and 3β-hydroxyandrost-1,5-diene-17-ethylene ketal, and methods for their use in the prevention and treatment of biological conditions mediated by androgen receptors. Thus, for example, compounds of the invention are useful in the prevention and treatment of prostrate cancer. Furthermore, it has been discovered that compounds of the invention are useful in the prevention and treatment of androgen-independent cancers such as androgen-independent prostrate cancer. Finally, inventive compounds may be used to treat antiandrogen induced withdrawal syndrome.

  本发明提供了强效的抗雄激素化合物，例如3β-乙酰氧基雄烯-1,5-二烯-17-乙烯基酮和3β-羟基雄烯-1,5-二烯-17-乙烯基酮，以及它们在通过雄激素受体介导的生物状况的预防和治疗中的应用方法。因此，例如，本发明的化合物在预防和治疗前列腺癌方面是有用的。此外，已经发现本发明的化合物在预防和治疗雄激素非依赖性癌症，如雄激素非依赖性前列腺癌方面是有用的。最后，本发明的化合物可以用于治疗抗雄激素诱导的戒断综合征。