Cyanomethoxycarbonylketene-bis-(ethyl-mercaptal) | 17823-60-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 乙烯基硫酯
• 英文名称: Cyanomethoxycarbonylketene-bis-(ethyl-mercaptal)
• 英文别名: Methyl 2-cyano-3,3-bis(ethylsulfanyl)prop-2-enoate
• CAS: 17823-60-8
• 化学式: C₉H₁₃NO₂S₂
• 分子量: 231.34
• InChiKey: SZGBCJBSKKMIGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  101
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-(4-(2-溴乙氧基)苯基)乙酮 、 Cyanomethoxycarbonylketene-bis-(ethyl-mercaptal) 在 氢氧化钾 作用下， 以46%的产率得到4-Ethylsulfanyl-6-[4-(2-ethylsulfanyl-ethoxy)-phenyl]-2-oxo-2H-pyran-3-carbonitrile
  参考文献：
  名称：

  6-Aryl-4-methylsulfanyl-2H-pyran-2-one-3-carbonitriles as PPAR-γ activators

  摘要：

  Various 6-aryl-3-cyano/methoxycarbonyl-4-methylsulfanyl-2H-pyran-2-ones have been synthesized as a potential substitute of 2,4-thiazolidinedione head group to express potent PPAR-gamma transactivation response. Some of the screened compounds have shown promising PPAR-gamma agonistic activity. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.05.031

文献信息

• [EN] SUBSTITUTED FLUORANTHENE-7-CARBONITRILES AS FLUORESCENT DYES FOR CELL IMAGING APPLICATIONS<br/>[FR] FLUORANTHÈNE-7-CARBONITRILES SUBSTITUÉS UTILISÉS EN TANT QUE COLORANTS FLUORESCENTS POUR DES APPLICATIONS D'IMAGERIE CELLULAIRE
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2014147642A1

  公开（公告）日：2014-09-25

  The present invention relates to novel donor-acceptor fluoranthenes of the general formula I which can be used potentially in developing fluorescent probes, and a process of preparing said novel compounds. More particularly, the present invention relates to amine or alkoxy group as donor and nitrile group as an acceptor attached to the fluoranthene skeleton, processes for preparing the said compounds and their uses as fluorescent probes in chemical and biological sciences such as cell imaging applications, diagnostics, fluorescent tags and other useful applications. The compounds are prepared by reacting 2H-pyran-2-ones in isolated or rigid conformations with cyclic ketones containing methylene carbonyl moiety in the presence of a base in an organic solvent.

  本发明涉及一种新型供体-受体氟蒽化合物，其通式为I，可能用于开发荧光探针，并提供了制备这些新型化合物的方法。更具体地说，本发明涉及将胺或烷氧基作为供体，将腈基作为受体连接到氟蒽骨架上，制备这些化合物的方法，以及它们在化学和生物科学中作为荧光探针的用途，如细胞成像应用、诊断、荧光标记和其他有用的应用。这些化合物是通过在有机溶剂中在孤立或刚性构象下，将2H-吡喃-2-酮与含有亚甲基羰基团的环状酮在碱存在下反应而制备的。
• 6-Aryl-4-methylsulfanyl-2H-pyran-2-one-3-carbonitriles as PPAR-γ activators
  作者：Ashoke Sharon、Ramendra Pratap、Rit Vatsyayan、Prakas R. Maulik、Uma Roy、Atul Goel、Vishnu Ji Ram

  DOI：10.1016/j.bmcl.2005.05.031

  日期：2005.7

  Various 6-aryl-3-cyano/methoxycarbonyl-4-methylsulfanyl-2H-pyran-2-ones have been synthesized as a potential substitute of 2,4-thiazolidinedione head group to express potent PPAR-gamma transactivation response. Some of the screened compounds have shown promising PPAR-gamma agonistic activity. (c) 2005 Elsevier Ltd. All rights reserved.