N-(4-乙酰氨基苯基)-3-羟基萘-2-甲酰胺 | 41506-62-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: N-(4-乙酰氨基苯基)-3-羟基萘-2-甲酰胺
• 中文别名: N-(4-乙酰基氨基苯基)-3-羟基萘-2-羧酰胺
• 英文名称: N-[4-(acetylamino)phenyl]-3-hydroxy-2-naphthaleneformamide
• 英文别名: 3-hydroxy-N-(4-acetamidophenyl)-2-naphthaleneamide；1-acetylamino-4-(3-hydroxy-[2]naphthoylamino)-benzene；1-Acetylamino-4-(3-hydroxy-[2]naphthoylamino)-benzol；N-(4-acetylaminophenyl)-3-hydroxynaphthalene-2-carboxamide；N-(4-acetamidophenyl)-3-hydroxynaphthalene-2-carboxamide
• CAS: 41506-62-1
• 化学式: C₁₉H₁₆N₂O₃
• 分子量: 320.348
• InChiKey: MSRUOXBBGPWHEG-UHFFFAOYSA-N

物化性质

• 沸点：
  603.7℃ at 101.325kPa
• 密度：
  1.375g/cm3 at 23℃
• LogP：
  3.1 at 23℃ and pH7.8

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  78.4
• 氢给体数：
  3
• 氢受体数：
  3

安全信息

• 海关编码：
  2924299090

反应信息

• 作为反应物：
  描述：

  N-(4-乙酰氨基苯基)-3-羟基萘-2-甲酰胺 在 五氯化磷 作用下， 以 1,4-二氧六环 为溶剂， 反应 1.0h， 生成 [3-[(4-acetamidophenyl)carbamoyl]naphthalen-2-yl] dihydrogen phosphate
  参考文献：
  名称：

  Fluorescent Substrates for Potential Use in Enzyme-Linked Immunosorbent Assay of Membrane-Bound Nucleic Acids

  摘要：

  A number of phosphorylated fluorochromes were synthesized and tested for the alkaline phosphatase-linked fluorescence assay of membrane-bound nucleic acids. 3-Hydroxy-N-2'-biphenyl-2-naphthalenecarboxamide phosphate ester (HBNP) was found to be the most suitable for the assay. Nonfluorescent HBNP is hydrolyzed by phospholipase bound to the probe DNA to the highly fluorescent 3-hydroxy-N,2'-biphenyl-2-naphthalenecarboxamide (HBN). HBN is insoluble enough in aqueous medium to precipitate on the nylon membrane. Spots containing as little as 5 fg of lambda DNA can be successfully detected on the membrane with HBNP.

  DOI：

  10.1021/ac00080a022
• 作为产物：
  描述：

  4′-氨基乙酰苯胺 、 2-羟基-3-萘甲酸 在 三氯化磷 作用下， 生成 N-(4-乙酰氨基苯基)-3-羟基萘-2-甲酰胺
  参考文献：
  名称：

  Fluorescent Substrates for Potential Use in Enzyme-Linked Immunosorbent Assay of Membrane-Bound Nucleic Acids

  摘要：

  A number of phosphorylated fluorochromes were synthesized and tested for the alkaline phosphatase-linked fluorescence assay of membrane-bound nucleic acids. 3-Hydroxy-N-2'-biphenyl-2-naphthalenecarboxamide phosphate ester (HBNP) was found to be the most suitable for the assay. Nonfluorescent HBNP is hydrolyzed by phospholipase bound to the probe DNA to the highly fluorescent 3-hydroxy-N,2'-biphenyl-2-naphthalenecarboxamide (HBN). HBN is insoluble enough in aqueous medium to precipitate on the nylon membrane. Spots containing as little as 5 fg of lambda DNA can be successfully detected on the membrane with HBNP.

  DOI：

  10.1021/ac00080a022

文献信息

• Pigment compositions for solvent and water-based ink systems and the methods for producing them
  申请人：HOECHST CELANESE CORPORATION

  公开号：EP0592907A1

  公开（公告）日：1994-04-20

  This invention is an azo pigment composition containing a water insoluble metal salt of a water soluble polymer; a method of preparing said composition and ink compositions prepared from said azo pigment compositions.

  这项发明是一种含有水不溶性金属盐的水溶性聚合物的偶氮颜料组合物；一种制备该组合物的方法以及由该偶氮颜料组合物制备的油墨组合物。
• 一种颜料橙PO-38的工业化生产方法
  申请人：浙江科隆颜料科技有限公司

  公开号：CN107629479A

  公开（公告）日：2018-01-26

  本发明公开了一种颜料橙PO‑38的工业化生产方法。它以2‑氯‑5‑甲酰胺基苯胺、3‑羟基‑N‑（4‑乙酰胺基苯基）‑2‑萘甲酰胺为原料，经成盐反应、重氮化反应、酸析反应及偶合反应得到颜料橙PO‑38。本发明加入混合助剂，提高偶合反应效率，改善该红光颜料橙的色光；通过反酸析，调整加料顺序，将3‑羟基‑N‑（4‑乙酰胺基苯基）‑2‑萘甲酰胺溶解液加入到酸溶液中，使AS‑P分子在足够多的酸溶液中立即形成负离子变成细小的颗粒，避免AS‑P分子继续与其他的分子结合变大，从而可以使合成的颜料分子变细小，以致提高颜料性能；其反应条件温和，对设备要求低，反应时间短，改性剂较常见，改性剂应用难度较小，得到的产物红光颜料橙PO‑38性能好，其耐热性达到200℃，耐光牢度5级。
• Improved azo pigment compositions and process for their preparation
  申请人：HOECHST CELANESE CORPORATION

  公开号：EP0544495A1

  公开（公告）日：1993-06-02

  This invention is that of an azo pigment composition containing about 1 to 10 percent by weight of a nonionic alkyl polyglycoside dispersing agent. The polyglycosides useful in the invention have the general formulae:CnH2n+1 M (C₆H₁₀O₅)x H wherein: m is an oxygen, sulfur, nitrogen phosphorous or silicon atom; n is an integer from 8 to 18, preferably 8 to 11 and X represents the number average degree of polymerization having a numerical value from about 1 to about 2. These azo pigment compositions are prepared by conducting the azo pigment coupling reaction in the presence of said alkyl polyglycoside. The resulting pigment exhibit superior application properties in water based ink systems.

  本发明是一种偶氮颜料组合物，含有约 1-10%（按重量计）的非离子烷基多糖苷分散剂。本发明中的聚糖苷具有以下通式： CnH2n+1 M (C₆H₁₀O₅)x H 其中：m 是氧原子、硫原子、氮磷原子或硅原子；n 是 8 至 18 的整数，最好是 8 至 11；X 代表平均聚合度，数值约为 1 至 2。 这些偶氮颜料组合物是在所述烷基聚糖苷存在下进行偶氮颜料偶联反应制备的。所得颜料在水性油墨体系中具有优异的应用性能。
• A HYBRID PIGMENT, METHOD FOR PREPARATION THEREOF AND USES THEREOF
  申请人：Clariant Plastics & Coatings Ltd

  公开号：EP3561003A1

  公开（公告）日：2019-10-30

  The present invention relates to a hybrid pigment with high opacity comprising organic-inorganic pigment and uses thereof. The present invention also relates to a process for synthesizing the hybrid pigment and using said pigment in varnishes, paints, inks, plastics and coating materials.

  本发明涉及一种由有机-无机颜料组成的高不透明度杂化颜料及其用途。本发明还涉及一种合成杂化颜料并将其用于清漆、油漆、墨水、塑料和涂层材料的工艺。
• TWI515265
  申请人：——

  公开号：——

  公开（公告）日：——