furan-2,5-dione; 1H-indene | 28476-72-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚和异茚
• 英文名称: furan-2,5-dione; 1H-indene
• 英文别名: furan-2,5-dione;1H-indene
• CAS: 28476-72-4
• 化学式: C13H10O3
• 分子量: 214.22
• InChiKey: ILXSCDUHHGVMOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.076
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Compositions and methods for enhanced mucosal delivery of Y2 receptor-binding peptides and methods for treating and preventing obesity
  申请人：Nastech Pharmaceutical Company Inc.

  公开号：US20040157777A1

  公开（公告）日：2004-08-12

  Pharmaceutical compositions and methods are described comprising at least one Y2 receptor-binding peptide, such as peptide YY(PYY), Neuropeptide Y (NPY) or Pancreatic Peptide (PP) and one or more mucosal delivery-enhancing agents for enhanced nasal mucosal delivery of the peptide YY, for treating a variety of diseases and conditions in mammalian subjects, including obesity.

  描述了包含至少一种Y2受体结合肽（如肽YY（PYY）、神经肽Y（NPY）或胰岛素肽（PP））和一种或多种黏膜传递增强剂的药物组合物和方法，以增强肽YY在鼻黏膜中的传递，用于治疗哺乳动物主体中的多种疾病和病况，包括肥胖。
• Intranasal administration of glucose-regulating peptides
  申请人：Quay C. Steven

  公开号：US20050143303A1

  公开（公告）日：2005-06-30

  Pharmaceutical compositions and methods are described comprising at least one glucose-regulating peptide, such as amylin, glucagon-like peptide-1 (GLP), pramlintide or exendin-4 and one or more mucosal delivery-enhancing agents for enhanced nasal mucosal delivery of the amylin, for treating a variety of diseases and conditions in mammalian subjects, including obesity and diabetes mellitus.

  本文介绍了一种药物组合和方法，其中包括至少一种调节葡萄糖的肽类，如降淀粉样肽、胰高血糖素样肽-1（GLP）、普拉林肽或外肽-4，以及一种或多种黏膜传递增强剂，以增强降淀粉样肽在鼻黏膜上的传递，用于治疗哺乳动物主体中的多种疾病和病况，包括肥胖和糖尿病。
• [EN] COMBINATIONS COMPRISING BREXPIPRAZOLE OR A SALT THEREOF AND A SECOND DRUG FOR USE IN THE TREATMENT OF A CNS DISORDER<br/>[FR] COMBINAISONS COMPRENANT DU BREXPIPRAZOLE OU UN SEL DE CELUI-CI ET UN SECOND MÉDICAMENT EN VUE D'UNE UTILISATION DANS LE TRAITEMENT D'UN TROUBLE DU SYSTÈME NERVEUX CENTRAL
  申请人：OTSUKA PHARMA CO LTD

  公开号：WO2012137971A1

  公开（公告）日：2012-10-11

  The present invention provides a medicament having a wider treatment spectrum, causing a fewer side effects and superior in tolerability and safety, as compared to known typical antipsychotic agents and atypical antipsychotic agents. The present invention related to a medicament containing (I) a compound which is 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one or a salt thereof, and (II) at least one drug selected from the group consisting of a mood stabilizer, a serotonin reuptake inhibitor, a norepinephrine reuptake inhibitor, a serotonin and norepinephrine reuptake inhibitor, a noradrenergic and specific serotonergic antidepressant, an antianxiety drug, a tricyclic antidepressant, a tetracyclic antidepressant, an antipsychotic drug and an anti-ADHD drug, in combination.

  本发明提供了一种药物，与已知的典型抗精神病药物和非典型抗精神病药物相比，具有更广泛的治疗范围，引起更少的副作用，并且在耐受性和安全性方面更为优越。本发明涉及一种药物，包含(I)化合物7-[4-(4-苯并[b]噻吩-4-基哌嗪-1-基)氧基]-1H-喹啉-2-酮或其盐，以及(II)至少一种药物，所述药物选自情绪稳定剂、血清素再摄取抑制剂、去甲肾上腺素再摄取抑制剂、血清素和去甲肾上腺素再摄取抑制剂、特异性去甲肾上腺素能抗抑郁药、抗焦虑药、三环抗抑郁药、四环抗抑郁药、抗精神病药和抗多动症药，进行组合。
• COMPOSITIONS AND METHODS FOR ENHANCED MUCOSAL DELIVERY OF PYY PEPTIDE
  申请人：Quay C. Steven

  公开号：US20070129299A1

  公开（公告）日：2007-06-07

  Pharmaceutical compositions are described comprising PYY(3-36) (SEQ ID NO: 2), a solubilizing agent, a lipid, a polyol.

  本文描述了一种药物组合物，其中包含PYY(3-36) (序列ID号：2)，一种溶解剂，一种脂质和一种多元醇。
• A DEVICE FOR ENHANCED EPITHELIAL PERMEATION OF Y2 RECEPTOR-BINDING PEPTIDES
  申请人：Quay C. Steven

  公开号：US20070161563A1

  公开（公告）日：2007-07-12

  A pharmaceutical device comprising a composition comprising an aqueous solution of PYY(3-36), a cyclodextrin, and a compound selected from phosphatidylcholine or diglyceride, wherein the cyclodextrin and the compound selected from phosphatidylcholine or diglyceride are present in an amount sufficient to enhance epithelial permeation, and wherein the composition is present in a container; and an actuator fluidly connected to the container, wherein the actuator has a tip which defines a passage through which the solution is ejected to produce a spray of the solution.

  一种药物器具，包括一种组合物，该组合物包括PYY（3-36）的水溶液、环糊精和从磷脂酰胆碱或二甘酸选择的化合物，其中环糊精和从磷脂酰胆碱或二甘酸选择的化合物的含量足以增强上皮渗透，且该组合物存在于容器中；以及与容器流体连接的作动器，其中作动器具有一个尖端，其定义了一个通道，通过该通道喷射出解液以产生解液喷雾。