N-(2-(3,4-dimethoxyphenyl)-1,2,3,4-tetrahydronaphthalen-2-yl)-4-methylbenzenesulfonamide | 1036030-79-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-(2-(3,4-dimethoxyphenyl)-1,2,3,4-tetrahydronaphthalen-2-yl)-4-methylbenzenesulfonamide
• 英文别名: N-[2-(3,4-dimethoxyphenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]-4-methylbenzenesulfonamide
• CAS: 1036030-79-1
• 化学式: C₂₅H₂₇NO₄S
• 分子量: 437.56
• InChiKey: LQCUELSYEGUKNI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  73
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  邻苯二甲醚 、 N-(4-tolylsulfonyl)-1,2,3,4-tetrahydronaphthalene-1,2-imine 在 三氯化铁 作用下， 以 硝基甲烷 为溶剂， 生成 N-(2-(3,4-dimethoxyphenyl)-1,2,3,4-tetrahydronaphthalen-2-yl)-4-methylbenzenesulfonamide 、 N-(1-(3,4-dimethoxyphenyl)-1,2,3,4-tetrahydronaphthalen-2-yl)-4-methylbenzenesulfonamide
  参考文献：
  名称：

  FeCl3: an efficient catalyst for reactions of electron-rich arenes with imines or aziridines

  摘要：

  Iron(III) chloride was discovered highly effective as catalyst in the Friedel-Crafts reactions of electron-rich arenes with imines or aziridines. It was found that reactions of imines were highly substrate-dependent, which generated mono- or double-addition products, while arenes reacted with aziridines regioselectively leading to the formation of desired ring-opening products in 2 min with moderate to good yields. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.03.081

文献信息

• FeCl3: an efficient catalyst for reactions of electron-rich arenes with imines or aziridines
  作者：Zhiyong Wang、Xiaoyu Sun、Jie Wu

  DOI：10.1016/j.tet.2008.03.081

  日期：2008.5

  Iron(III) chloride was discovered highly effective as catalyst in the Friedel-Crafts reactions of electron-rich arenes with imines or aziridines. It was found that reactions of imines were highly substrate-dependent, which generated mono- or double-addition products, while arenes reacted with aziridines regioselectively leading to the formation of desired ring-opening products in 2 min with moderate to good yields. (C) 2008 Elsevier Ltd. All rights reserved.