7-methoxy-1,2-dimethylnaphthalene | 46279-28-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 7-methoxy-1,2-dimethylnaphthalene
• 英文别名: (7,8-dimethyl-[2]naphthyl)-methyl ether；(7,8-Dimethyl-[2]naphthyl)-methyl-aether
• CAS: 46279-28-1
• 化学式: C₁₃H₁₄O
• 分子量: 186.254
• InChiKey: APBVNEPABVMGNJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  7-methoxy-1,2-dimethylnaphthalene 在 盐酸 、 sodium 作用下， 生成 7,8-dimethyl-2-tetralone
  参考文献：
  名称：

  Bachule, M. T.; Mane, R. B., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1998, vol. 37, # 3, p. 281 - 284

  摘要：

  DOI：
• 作为产物：
  描述：

  5-(4-methoxyphenyl)-3-methylpentan-2-one 在 PPA 作用下， 反应 2.0h， 以63%的产率得到7-methoxy-1,2-dimethylnaphthalene
  参考文献：
  名称：

  Zeolite β-Induced Rearrangement of Alkoxybenzyl Allyl Ethers to Aldehydes and Ketones. 5.¹ Variation of the Allylic Moiety

  摘要：

  Allylic PMB ethers rearranged in the presence of zeolite beta to form 4-arylbutanals or 5-arylpentanones depending on the substituent pattern of the allylic moiety. Best results were obtained with substrates carrying simple substituents in the allylic 2-position, but a couple of substrates lacking a 2-substituent also rearranged. More functionalized substituents in this position were not tolerated. A propargyl PMB ether and a homoallylic PMB ether rearranged as well, but the products were mixtures of isomeric olefins. The 4-arylbutanals 2c and 2e and the 5-arylpentanone 2j were cyclized in PPA to give naphthalene and dihydronaphthalene derivatives, respectively.

  DOI：

  10.1021/jo972243o

文献信息

• DITERPENE DERIVATIVES FOR THE TREATMENT OF CARDIOVASCULAR, CANCER AND INFLAMMATORY DISEASES
  申请人：Dev Inderjit Kumar

  公开号：US20070207989A1

  公开（公告）日：2007-09-06

  The present invention relates to useful diterpenes and pharmaceutical compositions containing them of the formula: for use in the treatment of cardiovascular and inflammatory diseases and for cancers susceptible to an NF-κB inhibitor and an endothelin receptor inhibitor. The present invention also relates to compounds and methods useful to inhibit cell proliferation and for the induction of apoptosis.

  本发明涉及有用的二萜化合物及包含它们的药物组合物，用于治疗心血管和炎症性疾病，以及对NF-κB抑制剂和内皮素受体抑制剂敏感的癌症。本发明还涉及用于抑制细胞增殖和诱导凋亡的化合物和方法。
• Selective sp3 C-H Bond Activation Based on a Carbocation Relay: Friedel-Crafts Reaction with Alkanes as the Alkylating Component
  作者：Jie Wang、Pengfei Zhou、Yang Wang

  DOI：10.1002/ejoc.201001118

  日期：2011.1

  4-methylpentyl-substituted aromatics has been developed using a carbocation relay strategy through selective sp 3 C-H bond activation, providing a facile and cost-effective approach for the construction of benzocyclic compounds. A variety of 1,1-dimethylindane and naphthalene derivatives have been prepared from very simple starting materials in good yields with high selectivity. The present strategy

  使用碳阳离子中继策略通过选择性 sp 3 CH 键活化开发了一种高效且选择性的 3-甲基丁基或 4-甲基戊基取代芳烃的分子内 Friedel-Crafts 反应，为构建苯并环提供了一种简便且经济的方法化合物。多种 1,1-二甲基茚满和萘衍生物已由非常简单的原料以高产率和高选择性制备。本策略提供了一个以烷烃为烷基化组分的 Friedel-Crafts 反应的新例子，并构成了选择性 CH 键活化和烷烃衍生物功能化的便捷方法。
• Preferential Electrocyclic Reaction of<i>o</i>-Quinodimethane. New Route to Dihydronaphthalenes and Naphthalenes
  作者：Kozo Shishido、Akitake Yamashita、Kou Hiroya、Keiichiro Fukumoto、Tetsuji Kametani

  DOI：10.1246/cl.1987.2113

  日期：1987.11.5

  Substituted dihydronaphthalenes and naphthalenes are obtained via a preferential electrocyclic reaction of o-quinodimethanes generated by the thermolysis of 1-alkyl-1-alkenylbenzocyclobutenes.

  取代的二氢萘和萘是通过 1-烷基-1-烯基苯并环丁烯热解产生的邻醌二甲烷的优先电环反应获得的。
• Madhushaw, Reniguntala J.; Lo, Ching-Yu; Hwang, Chun-Wei, Journal of the American Chemical Society, 2004, vol. 126, # 47, p. 15560 - 15565
  作者：Madhushaw, Reniguntala J.、Lo, Ching-Yu、Hwang, Chun-Wei、Su, Ming-Der、Shen, Hung-Chin、Pal, Sitaram、Shaikh, Isak R.、Liu, Rai-Shung

  DOI：——

  日期：——
• Amido substituted divalent chalcogenide fog inhibiting agents for silver halide photography
  申请人：EASTMAN KODAK COMPANY (a New Jersey corporation)

  公开号：EP0201201B1

  公开（公告）日：1991-01-02