(4S)-1-(4-hydroxybutyl)-4-methyl-3-(2-naphthalen-1-ylethyl)imidazolidin-2-one | 1037175-94-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (4S)-1-(4-hydroxybutyl)-4-methyl-3-(2-naphthalen-1-ylethyl)imidazolidin-2-one
• CAS: 1037175-94-2
• 化学式: C₂₀H₂₆N₂O₂
• 分子量: 326.439
• InChiKey: DWCPTYQIWWXQBL-INIZCTEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-萘乙酸 、 N-叔丁氧羰基-L-丙氨酸 、 N,N'-羰基二咪唑 、 alkaline earth salt of/the/ methylsulfuric acid 以81%的产率得到(4S)-1-(4-hydroxybutyl)-4-methyl-3-(2-naphthalen-1-ylethyl)imidazolidin-2-one
  参考文献：
  名称：

  High-throughput parallel synthesis of 3,4-disubstituted 1-(ω-hydroxyalkyl) imidazolin-2-ones on ‘volatilizable’ supports

  摘要：

  A solid-phase synthesis of 3,4-disubstituted 1-(omega-hydroxyalkyl) imidazolin-2-ones on the 'volatilizable' aminoalkyl functionalized silica gel is reported. The desired products were cleaved by a two-step procedure in good purity and yield. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.03.156

文献信息

• High-throughput parallel synthesis of 3,4-disubstituted 1-(ω-hydroxyalkyl) imidazolin-2-ones on ‘volatilizable’ supports
  作者：Yangmei Li、Yongping Yu、Marc Giulianotti、Richard A. Houghten

  DOI：10.1016/j.tetlet.2008.03.156

  日期：2008.5

  A solid-phase synthesis of 3,4-disubstituted 1-(omega-hydroxyalkyl) imidazolin-2-ones on the 'volatilizable' aminoalkyl functionalized silica gel is reported. The desired products were cleaved by a two-step procedure in good purity and yield. (C) 2008 Elsevier Ltd. All rights reserved.