3α-phenylmethoxy-3β-(3,4-dichlorophenyl)-nortropane | 1204302-91-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3α-phenylmethoxy-3β-(3,4-dichlorophenyl)-nortropane
• CAS: 1204302-91-9
• 化学式: C₂₀H₂₁Cl₂NO
• 分子量: 362.299
• InChiKey: SGWFXQFBBZKSIH-YRWFTTLQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.32
• 重原子数：
  24.0
• 可旋转键数：
  4.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  21.26
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  3α-phenylmethoxy-3β-(3,4-dichlorophenyl)-nortropane 、 草酸 以 四氢呋喃 为溶剂， 生成 3α-phenylmethoxy-3β-(3,4-dichlorophenyl)-nortropane oxalate
  参考文献：
  名称：

  Synthesis and monoamine transporter affinity of 3α-arylmethoxy-3β-arylnortropanes

  摘要：

  A series of 3-arylnortrop-2-enes and 3 alpha-arylmethoxy-3 beta-arylnortropanes were synthesized and evaluated for binding affinity at monoamine transporters. The 3-(3,4-dichlorophenyl)nortrop-2-ene (6e) exhibited high affinity for the SERT (K-i = 0.3 nM). The 3 alpha-arylmethoxy-3 beta-arylnortropanes were generally SERT selective with the 3 alpha-(3,4-dichlorophenylmethoxy)-3 beta phenylnortrop-2-ene (7c) possessing subnanomolar potency (K-i = 0.061 nM). However, 3 alpha-(3,4-dichlorophenylmethoxy)-3 beta-phenylnortrop-2-ene (7b) exhibited high affinity at all three transporters [(DAT K-i = 22 nM), (SERT K-i = 6 nM) and (NET K-i = 101 nM)]. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.10.087
• 作为产物：
  描述：

  8-ethoxycarbonyl-3α-phenylmethoxy-3β-(3,4-dichlorophenyl)-8-azabicyclo[3.2.1]octane 在 一水合肼 、 potassium hydroxide 作用下， 以 乙二醇 为溶剂， 反应 3.0h， 以92%的产率得到3α-phenylmethoxy-3β-(3,4-dichlorophenyl)-nortropane
  参考文献：
  名称：

  Synthesis and monoamine transporter affinity of 3α-arylmethoxy-3β-arylnortropanes

  摘要：

  A series of 3-arylnortrop-2-enes and 3 alpha-arylmethoxy-3 beta-arylnortropanes were synthesized and evaluated for binding affinity at monoamine transporters. The 3-(3,4-dichlorophenyl)nortrop-2-ene (6e) exhibited high affinity for the SERT (K-i = 0.3 nM). The 3 alpha-arylmethoxy-3 beta-arylnortropanes were generally SERT selective with the 3 alpha-(3,4-dichlorophenylmethoxy)-3 beta phenylnortrop-2-ene (7c) possessing subnanomolar potency (K-i = 0.061 nM). However, 3 alpha-(3,4-dichlorophenylmethoxy)-3 beta-phenylnortrop-2-ene (7b) exhibited high affinity at all three transporters [(DAT K-i = 22 nM), (SERT K-i = 6 nM) and (NET K-i = 101 nM)]. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.10.087

文献信息

• Synthesis and monoamine transporter affinity of 3α-arylmethoxy-3β-arylnortropanes
  作者：Harneet Kaur、Sari Izenwasser、Abha Verma、Dean Wade、Amy Housman、Edwin D. Stevens、David L. Mobley、Mark L. Trudell

  DOI：10.1016/j.bmcl.2009.10.087

  日期：2009.12

  A series of 3-arylnortrop-2-enes and 3 alpha-arylmethoxy-3 beta-arylnortropanes were synthesized and evaluated for binding affinity at monoamine transporters. The 3-(3,4-dichlorophenyl)nortrop-2-ene (6e) exhibited high affinity for the SERT (K-i = 0.3 nM). The 3 alpha-arylmethoxy-3 beta-arylnortropanes were generally SERT selective with the 3 alpha-(3,4-dichlorophenylmethoxy)-3 beta phenylnortrop-2-ene (7c) possessing subnanomolar potency (K-i = 0.061 nM). However, 3 alpha-(3,4-dichlorophenylmethoxy)-3 beta-phenylnortrop-2-ene (7b) exhibited high affinity at all three transporters [(DAT K-i = 22 nM), (SERT K-i = 6 nM) and (NET K-i = 101 nM)]. (C) 2009 Elsevier Ltd. All rights reserved.