5-(Naphthalen-2-yl-phenyl-amino)-thiophene-2-carboxylic acid | 349533-49-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 5-(Naphthalen-2-yl-phenyl-amino)-thiophene-2-carboxylic acid
• 英文别名: 5-(N-naphthalen-2-ylanilino)thiophene-2-carboxylic acid
• CAS: 349533-49-9
• 化学式: C₂₁H₁₅NO₂S
• 分子量: 345.422
• InChiKey: MPRRTHHFMUIPPY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  68.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-(Naphthalen-2-yl-phenyl-amino)-thiophene-2-carboxylic acid 生成 2-[(naphthalen-2-yl)(phenyl)amino]thiophene
  参考文献：
  名称：

  A Simple Route to N-Arylated 2-Aminothiophenes as a New Class of Amorphous Glass Forming Molecules

  摘要：

  [GRAPHICS]By thermal decarboxylation of N-arylated 2-aminothiophene-5-cacrboxylates, a versatile, heavy-metal free method for preparing the title compounds as new class of highly reactive and easily oxidable, amorphous glass forming molecules has been elaborated.

  DOI：

  10.1021/ol015875c
• 作为产物：
  描述：

  N-(2-naphthyl)-N-phenyl-acetamide 在 氢氧化钾 、 三乙胺 、 三氯氧磷 作用下， 以 甲醇 、 水 为溶剂， 生成 5-(Naphthalen-2-yl-phenyl-amino)-thiophene-2-carboxylic acid
  参考文献：
  名称：

  A Simple Route to N-Arylated 2-Aminothiophenes as a New Class of Amorphous Glass Forming Molecules

  摘要：

  [GRAPHICS]By thermal decarboxylation of N-arylated 2-aminothiophene-5-cacrboxylates, a versatile, heavy-metal free method for preparing the title compounds as new class of highly reactive and easily oxidable, amorphous glass forming molecules has been elaborated.

  DOI：

  10.1021/ol015875c

文献信息

• A Simple Route to <i>N-</i>Arylated 2-Aminothiophenes as a New Class of Amorphous Glass Forming Molecules
  作者：Horst Hartmann、Peter Gerstner、Dirk Rohde

  DOI：10.1021/ol015875c

  日期：2001.5.1

  [GRAPHICS]By thermal decarboxylation of N-arylated 2-aminothiophene-5-cacrboxylates, a versatile, heavy-metal free method for preparing the title compounds as new class of highly reactive and easily oxidable, amorphous glass forming molecules has been elaborated.