N-(氨基羰基)-2,2,2-三氯乙酰胺 | 6943-66-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 中文名称: N-(氨基羰基)-2,2,2-三氯乙酰胺
• 英文名称: 1-(2,2,2-trichloroacetyl)urea
• 英文别名: N-trichloroacetylurea；trichloroacetylurea；trichloroacetyl-urea；Trichloracetyl-harnstoff；Trichloressigsaeure-ureid；Mono-(trichloracetyl)-harnstoff；Urea, trichloroacetyl-；N-carbamoyl-2,2,2-trichloroacetamide
• CAS: 6943-66-4
• 化学式: C₃H₃Cl₃N₂O₂
• 分子量: 205.428
• InChiKey: FZHBSPOQTSBETC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  72.2
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2924210090

反应信息

• 作为反应物：
  描述：

  N-(氨基羰基)-2,2,2-三氯乙酰胺 在 乙醇 、 sodium iodide 作用下， 生成 triiodoacetyl-urea
  参考文献：
  名称：

  Halogen-acetylureas

  摘要：

  DOI：

  10.1021/ja01875a016
• 作为产物：
  描述：

  三氯乙酰异氰酸酯 在 氨 作用下， 以 二氯甲烷 为溶剂， 以94%的产率得到N-(氨基羰基)-2,2,2-三氯乙酰胺
  参考文献：
  名称：

  Evaluation of anticonvulsant and analgesic effects of benzyl- and benzhydryl ureides

  摘要：

  The anticonvulsant effects of benzyl- and benzhydryl ureides in mice models of seizures (maximal electroshock seizure test, pentylenetetrazol test, picrotoxin-induced seizure test) and the influence on spontaneous locomotor activity has been assessed. Furthermore, the analgesic effect of ureide derivatives was studied in the hot-plate test in mice. Selected compounds were investigated for their in vitro interaction with adenosine receptors as well as the benzodiazepine binding site of GABA(A) receptors. This study demonstrated the strong anticonvulsant activity of several ureides in electrically or chemically induced seizure models, and structure-activity relationships were discussed. 1-Benzyl-3-butyrylurea (9) was found to be equipotent to ethosuximide in the pentylenetetrazol test with regard to the number of attacks as well as the time of the onset of seizures. The ureide 9 also revealed the highest protective activity against seizures in the other models, maximal electroshock seizure and picrotoxin test. Moreover, 1-benzyl-3-butyrylurea was not neurotoxic at doses up to 200 mg/kg. Benzylureides 8-10 showed affinity to the adenosine A, receptors at low micromolar concentrations. However, the apparent anticonvulsant activity in different seizure models does not appear to result from direct activation of adenosine A, receptors or GABAA receptors, respectively. In the hot-plate test, the majority of investigated compounds exhibited analgesic activity. Again, compound 9 was superior to the other substances investigated, suggesting a potential therapeutic value of that ureide derivative. (c) 2006 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ejphar.2006.12.002

文献信息

• [EN] PYRIDINE SULFONAMIDES<br/>[FR] SULFONAMIDES DE PYRIDINE
  申请人：AMGEN INC

  公开号：WO2018017896A1

  公开（公告）日：2018-01-25

  The present invention provides compounds of Formula (I), as defined in the specification, or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav 1.7. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders, cough, or itch. Also provided are pharmaceutical compositions containing compounds of the present invention.

  本发明提供了如规范中定义的Formula (I)的化合物，或其药用可接受的盐，这些化合物是电压门控钠通道的抑制剂，特别是Nav 1.7。这些化合物对于治疗可通过抑制钠通道治疗的疾病如疼痛障碍、咳嗽或瘙痒是有用的。还提供了含有本发明化合物的药物组合物。
• Substituted pyrazolo[1,5-a] pyrimidines and process for making same
  申请人：Wang Daniel Yanong

  公开号：US20060063785A1

  公开（公告）日：2006-03-23

  This invention relates to novel pyrazolo[1,5-a]pyrimidine compounds and the therapeutically acceptable salts thereof. These compounds are useful as anti-proliferative agents in mammals, including humans.

  这项发明涉及新型吡唑并[1,5-a]嘧啶化合物及其治疗上可接受的盐。这些化合物在哺乳动物，包括人类中作为抗增殖剂是有用的。
• [EN] SUBSTITUTED THIOPHENES AND USES THEREOF<br/>[FR] THIOPHENES SUBSTITUES ET LEURS UTILISATIONS
  申请人：ASTRAZENECA AB

  公开号：WO2005016909A1

  公开（公告）日：2005-02-24

  This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical salts, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cancer.

  这项发明涉及具有结构式（I）的新化合物，以及它们的药用盐、组合物和使用方法。这些新化合物可用于治疗或预防癌症。
• [EN] PROCESS TO PREPARE MALAYAMYCIN DERIVATIVES<br/>[FR] PROCEDE DE PREPARATION DE DERIVES DE MALAYAMYCINE
  申请人：SYNGENTA LTD

  公开号：WO2004069842A1

  公开（公告）日：2004-08-19

  A process is provided for the preparation of a compound of the general formula (I): wherein R is H or C1-4 alkyl, which comprises treating a compound of the general formula (II): where R' is R or R8CO, R is as defined above, R8 is C1-8 alkyl or optionally substituted phenyl and R9 is optionally substituted C1-8 alkyl or optionally substituted aryl, with an amine R''NH2 wherein R'' is H or C1-4 alkyl. Also provided are the trans isomers of the compound (I) where R is CH3 (6-epi-malayamycin A) and H (6-epi-desmethylmalayamycin A), the cis and trans isomers of the compound (I) where R is C2-4 alkyl and various intermediate compounds.

  提供一种制备通式（I）化合物的过程：其中R为H或C1-4烷基，包括处理通式（II）化合物的步骤：其中R'为R或R8CO，R如上所定义，R8为C1-8烷基或可选择取代的苯基，R9为可选择取代的C1-8烷基或可选择取代的芳基，与胺R''NH2反应，其中R''为H或C1-4烷基。还提供了化合物（I）的顺式异构体，其中R为CH3（6-epi-malayamycin A）和H（6-epi-desmethylmalayamycin A），以及化合物（I）的顺式和反式异构体，其中R为C2-4烷基和各种中间化合物。
• Thiophene derivatives as chk 1 inhibitors
  申请人：Ashwell Susan

  公开号：US20070010556A1

  公开（公告）日：2007-01-11

  This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of cancer.

  本发明涉及具有结构式（I）的新化合物，以及它们的制药组合物和使用方法。这些新化合物提供了治疗或预防癌症的方法。