N,N-dicyclohexyl-1,1-dideutrioethylamine | 1314172-10-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N-dicyclohexyl-1,1-dideutrioethylamine
• 英文别名: N-cyclohexyl-N-(1,1-dideuterioethyl)cyclohexanamine
• CAS: 1314172-10-5
• 化学式: C₁₄H₂₇N
• 分子量: 211.359
• InChiKey: XRKQMIFKHDXFNQ-CBTSVUPCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N,N-二环己基乙酰胺 在 deutero lithium aluminiumhydride 作用下， 以779 mg的产率得到N,N-dicyclohexyl-1,1-dideutrioethylamine
  参考文献：
  名称：

  A Tertiary Amine as A Hydride Donor: Trichlorosilyl Triflate-mediated Conjugate Reduction of Unsaturated Ketones

  摘要：

  Bulky tertiary amines, especially dicyclohexylisobutylamine, smoothly reduced alpha,beta-unsaturated ketones in the presence of trichlorosilyl triflate to give the corresponding saturated ketones In excellent yields. Isotope-labeling studies revealed that an alpha-hydrogen of the amine was transferred to the enones during reduction.

  DOI：

  10.1021/ol2014895
• 作为试剂：
  描述：

  苯亚甲基苯乙酮 在 N,N-dicyclohexyl-1,1-dideutrioethylamine 、 Trichloro(trifluoromethylsulfonyloxy)silane 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以47%的产率得到3-deuterio-1,3-diphenyl-1-propanone
  参考文献：
  名称：

  A Tertiary Amine as A Hydride Donor: Trichlorosilyl Triflate-mediated Conjugate Reduction of Unsaturated Ketones

  摘要：

  Bulky tertiary amines, especially dicyclohexylisobutylamine, smoothly reduced alpha,beta-unsaturated ketones in the presence of trichlorosilyl triflate to give the corresponding saturated ketones In excellent yields. Isotope-labeling studies revealed that an alpha-hydrogen of the amine was transferred to the enones during reduction.

  DOI：

  10.1021/ol2014895

文献信息

• A Tertiary Amine as A Hydride Donor: Trichlorosilyl Triflate-mediated Conjugate Reduction of Unsaturated Ketones
  作者：Shunsuke Kotani、Kazuki Osakama、Masaharu Sugiura、Makoto Nakajima

  DOI：10.1021/ol2014895

  日期：2011.8.5

  Bulky tertiary amines, especially dicyclohexylisobutylamine, smoothly reduced alpha,beta-unsaturated ketones in the presence of trichlorosilyl triflate to give the corresponding saturated ketones In excellent yields. Isotope-labeling studies revealed that an alpha-hydrogen of the amine was transferred to the enones during reduction.