N²,N²-bis-(2-hydroxy-ethyl)-pyridine-2,5-diyldiamine | 4928-47-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N²,N²-bis-(2-hydroxy-ethyl)-pyridine-2,5-diyldiamine
• 英文别名: N²,N²-Bis-(2-hydroxy-aethyl)-pyridin-2,5-diyldiamin；6-[di-(2-hydroxyethyl)amino]pyridin-3-ylamine；2-[(5-Aminopyridin-2-yl)-(2-hydroxyethyl)amino]ethanol
• CAS: 4928-47-6
• 化学式: C₉H₁₅N₃O₂
• 分子量: 197.237
• InChiKey: BBGPIZRSRGELJX-UHFFFAOYSA-N

物化性质

• 沸点：
  460.1±45.0 °C(Predicted)
• 密度：
  1.306±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  82.6
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  bis-(2-hydroxy-ethyl)-(5-nitro-[2]pyridyl)-amine 在 盐酸 、 tin(ll) chloride 作用下， 生成 N²,N²-bis-(2-hydroxy-ethyl)-pyridine-2,5-diyldiamine
  参考文献：
  名称：

  Brown et al., Journal of the Chemical Society, <1957> 1544, 1547

  摘要：

  DOI：

文献信息

• Pyrazole compounds
  申请人：——

  公开号：US20030060453A1

  公开（公告）日：2003-03-27

  Pharmaceutical compositions and compounds are provided. The compounds of the invention demonstrate anti-proliferative activity, and may promote apoptosis in cells lacking normal regulation of cell cycle and death. In one embodiment of the invention, pharmaceutical compositions of the compounds in combination with a physiologically acceptable carrier are provided. The pharmaceutical compositions are useful in the treatment of hyperproliferative disorders, which disorders include tumor growth, lymphoproliferative diseases, angiogenesis. The compounds of the invention are substituted pyrazoles and pyrazolines.

  提供药物组合物和化合物。发明的化合物显示出抗增殖活性，并且可能促进缺乏正常细胞周期和死亡调控的细胞的凋亡。发明的一个实施例提供了化合物与生理可接受载体组合的药物组合物。该药物组合物可用于治疗过度增殖障碍，包括肿瘤生长、淋巴增殖性疾病、血管生成。发明的化合物是取代吡唑和吡唑啉。
• [EN] DIRECT DYES AND COMPOSITION COMPRISING THE DYES<br/>[FR] COLORANTS DIRECTS ET COMPOSITION LES COMPRENANT
  申请人：KAO GERMANY GMBH

  公开号：WO2016102207A1

  公开（公告）日：2016-06-30

  The present invention relates to novel direct dyes and compositions comprising them for dyeing keratin fibers especially human hair. The novel dyes of the present invention have benzothiophene structure providing intensive and homogeneous dyeing on keratin fibers, especially human hair.

  本发明涉及新型直接染料及包含它们的组合物，用于染色角蛋白纤维，特别是人类头发。本发明的新型染料具有苯并噻吩结构，在角蛋白纤维，特别是人类头发上提供强烈和均匀的染色。
• Immugenic compositions and diagnostic and therapeutic uses thereof
  申请人：Zhang Zaihui

  公开号：US20050272709A1

  公开（公告）日：2005-12-08

  Pharmaceutical compositions and compounds are provided. The compounds of the invention deomonstrate anti-proliferative activity, and may promote apoptosis in cells lacking normal regulation of cell cycle and death. In one embodiment of the invention, pharmaceutical compositions of the compounds in combination with a physiologically acceptable carrier are provided. The pharmaceutical compositions are useful in the treatment of hyperproliferative disorders, which disorders include tumor growth, lymphoproliferative diseases, angiogenesis. The compounds of the invention are substituted pyrazoles and pyrazolines.

  本发明提供了制药组合物和化合物。本发明的化合物表现出抗增殖活性，并可能促进缺乏正常细胞周期和死亡调节的细胞凋亡。在本发明的一种实施例中，提供了化合物与生理可接受载体的制药组合物。这些制药组合物可用于治疗高增殖性疾病，包括肿瘤生长、淋巴增殖性疾病、血管生成等疾病。本发明的化合物是取代的吡唑和吡唑啉。
• HYDRAZONOPYRAZOLE DERIVATIVES AND THEIR USE AS THERAPEUTICS
  申请人：Zhang Zaihui

  公开号：US20110237783A1

  公开（公告）日：2011-09-29

  Pharmaceutical compositions and compounds are provided. The compounds of the invention demonstrate anti-proliferative activity, and may promote apoptosis in cells lacking normal regulation of cell cycle and death. In one embodiment of the invention, pharmaceutical compositions of the compounds in combination with a physiologically acceptable carrier are provided. The pharmaceutical compositions are useful in the treatment of hyperproliferative disorders, which disorders include tumor growth, lymphoproliferative diseases, angiogenesis. The compounds of the invention are substituted pyrazoles and pyrazolines.

  本发明提供了药物组合物和化合物。本发明的化合物表现出抗增殖活性，并可能促进缺乏正常细胞周期和死亡调节的细胞凋亡。在本发明的一个实施例中，提供了与生理学上可接受的载体结合的化合物的药物组合物。这些药物组合物在治疗增生性疾病方面有用，这些疾病包括肿瘤生长、淋巴增生性疾病和血管生成等疾病。本发明的化合物是取代的吡唑和吡唑啉。
• Oxidative hair dyeing process with catalytic pretreatment
  申请人：Bristol-Myers Squibb Company

  公开号：EP0507448A2

  公开（公告）日：1992-10-07

  A pre-treatment solution for use in oxidatively dyeing hair comprises an aqueous solution of a complex of a transition metal ion, especially copper-II, and a chelating agent selected from 2,2′-dipyridyl and o-phenanthroline. A pretreatment process with this solution serves to conform the oxidative dyeing rate of virgin hair to that of the normally noncongruent rate of nonvirgin hair, so as to enhance the efficiency of the oxidative dyeing process, without reducing the intensity or variety of color. A hair treatment package in kit form comprising the aqueous solution and an oxidative hair dye mixture is also disclosed.

  一种用于氧化染发的预处理溶液包括过渡金属离子（尤其是铜Ⅱ）与选自 2,2′-二吡啶基和邻菲罗啉的螯合剂的络合物的水溶液。 用这种溶液进行预处理，可使原生发的氧化染色速率与非原生发的通常不一致的速率相一致，从而提高氧化染色过程的效率，而不降低颜色的强度或种类。此外，还公开了一种试剂盒形式的头发处理包，其中包括水溶液和氧化染发混合物。