毒理性
◉ 母乳喂养期间使用总结：有限的信息表明，母亲口服每日500毫克的剂量在乳汁中产生的水平较低，预计不会对哺乳婴儿造成任何不良影响，特别是如果婴儿年龄超过2个月。监测婴儿是否出现黄疸或其他肝脏毒性的迹象，尤其是在年龄较小、仅以母乳为食的婴儿中。一些来源建议在哺乳期间避免口服特比萘芬。[1]
◉ 母乳喂养期间未对局部特比萘芬进行研究。由于局部应用后只有大约1%被吸收，因此被认为对哺乳婴儿的风险较低。[1][2] 避免涂抹在乳头区域，并确保婴儿的皮肤不直接接触已涂抹药物的皮肤区域。只有水溶性的乳膏、凝胶或液体产品应涂抹在乳房上，因为软膏可能会使婴儿通过舔食接触到高水平的矿物石蜡。[3]
◉ 对哺乳婴儿的影响：截至修订日期，没有找到相关的已发布信息。
◉ 对泌乳和母乳的影响：截至修订日期，没有找到相关的已发布信息。
◉ Summary of Use during Lactation:Limited information indicates that oral maternal doses of 500 mg daily produce low levels in milk and would not be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months. Monitor the infant for jaundice or other signs of liver toxicity, especially in younger, exclusively breastfed infants. Some sources recommend avoiding oral terbinafine during nursing.[1]
Topical terbinafine has not been studied during breastfeeding. Because only about 1% is absorbed after topical application, it is considered a low risk to the nursing infant.[1][2] Avoid application to the nipple area and ensure that the infant's skin does not come into direct contact with the areas of skin that have been treated. Only water-miscible cream, gel or liquid products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking.[3]
◉ Effects in Breastfed Infants:Relevant published information was not found as of the revision date.
◉ Effects on Lactation and Breastmilk:Relevant published information was not found as of the revision date.
来源:Drugs and Lactation Database (LactMed)
