1-[(1-Hydroxy-2-methylpropan-2-yl)amino]tetradecan-2-ol | 1109228-07-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-[(1-Hydroxy-2-methylpropan-2-yl)amino]tetradecan-2-ol
• CAS: 1109228-07-0
• 化学式: C₁₈H₃₉NO₂
• 分子量: 301.513
• InChiKey: GGWSLVJRWPZREQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  21
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52.5
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-hydroxytetradecyl methanesulfonate 、 2-氨基-2-甲基-1-丙醇 以 乙醇 为溶剂， 生成 1-[(1-Hydroxy-2-methylpropan-2-yl)amino]tetradecan-2-ol
  参考文献：
  名称：

  Synthesis and Antileishmanial Activity of Lipidic Amino Alcohols

  摘要：

  In this work, a number of lipidic amino alcohols wereas synthesized and evaluated in vitro on cultures of Leishmania amazonensis and Leishmania chagasi. Nine amino alcohols showed inhibition of L. chagasi growth, and seven of them showed inhibition of L. amazonensis with IC50 below 10 μm. Compound 11f was more active than the reference drug amphotericin B against L. chagasi promastigote forms.

  DOI：

  10.1111/j.1747-0285.2009.00923.x

文献信息

• Synthesis and Antileishmanial Activity of Lipidic Amino Alcohols
  作者：Elaine S. Coimbra、Mauro V. de Almeida、Celso O. R. Júnior、Aline F. Taveira、Cristiane F. da Costa、Ana C. de Almeida、Elaine F. C. Reis、Adilson D. da Silva

  DOI：10.1111/j.1747-0285.2009.00923.x

  日期：2010.2

  In this work, a number of lipidic amino alcohols wereas synthesized and evaluated in vitro on cultures of Leishmania amazonensis and Leishmania chagasi. Nine amino alcohols showed inhibition of L. chagasi growth, and seven of them showed inhibition of L. amazonensis with IC50 below 10 μm. Compound 11f was more active than the reference drug amphotericin B against L. chagasi promastigote forms.