1-(3-Hydroxypropylamino)tetradecan-2-ol | 1109228-08-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-(3-Hydroxypropylamino)tetradecan-2-ol
• CAS: 1109228-08-1
• 化学式: C₁₇H₃₇NO₂
• 分子量: 287.486
• InChiKey: IQDZZMMXMAPNSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  20
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52.5
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-hydroxytetradecyl methanesulfonate 、 3-氨基-1-丙醇 以 乙醇 为溶剂， 生成 1-(3-Hydroxypropylamino)tetradecan-2-ol
  参考文献：
  名称：

  Synthesis and Antileishmanial Activity of Lipidic Amino Alcohols

  摘要：

  In this work, a number of lipidic amino alcohols wereas synthesized and evaluated in vitro on cultures of Leishmania amazonensis and Leishmania chagasi. Nine amino alcohols showed inhibition of L. chagasi growth, and seven of them showed inhibition of L. amazonensis with IC50 below 10 μm. Compound 11f was more active than the reference drug amphotericin B against L. chagasi promastigote forms.

  DOI：

  10.1111/j.1747-0285.2009.00923.x

文献信息

• EXPANDED COMPOSITE POLYSTYRENE-BASED RESIN PARTICLES AND EXPANDED MOLDED ARTICLE THEREOF
  申请人：Tsutsui Yasutaka

  公开号：US20130310475A1

  公开（公告）日：2013-11-21

  Expanded composite polystyrene-based resin particles having a plurality of cells and cell membranes separating the plurality of cells, said cell membranes including a polystyrene-based resin forming a continuous phase and polyacrylic acid alkyl ester-based resin fine particles dispersed in said continuous phase to form a dispersed phase, and said polystyrene-based resin being complexed with said polyacrylic acid alkyl ester-based resin fine particles, wherein said dispersed phase is present in the form of a plurality of layers in a cell membrane thickness direction in a cell membrane cross-section of said expanded composite polystyrene-based resin particles.
• US9127135B2
  申请人：——

  公开号：US9127135B2

  公开（公告）日：2015-09-08