N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-2,1,3-benzothiadiazole-4-sulfonamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-{3-[(2,5-dimethoxyphenyl)amino]quinoxalin-2-yl}-2,1,3-benzothiadiazole-4-sulfonamide
• 英文别名: N-[3-(2,5-dimethoxyanilino)quinoxalin-2-yl]-2,1,3-benzothiadiazole-4-sulfonamide
• 化学式: C₂₂H₁₈N₆O₄S₂
• 分子量: 494.555
• InChiKey: IDUJZGWPCFEXOH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  165
• 氢给体数：
  2
• 氢受体数：
  11

文献信息

• Pyrazine Derivatives and Use as P13k Inhibitors
  申请人：Gaillard Pascale

  公开号：US20090082356A1

  公开（公告）日：2009-03-26

  The present invention is related to pyrazine derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.

  本发明涉及式（I）的吡嗪衍生物，特别用于治疗和/或预防自身免疫性疾病和/或炎症性疾病、心血管疾病、神经退行性疾病、细菌或病毒感染、肾脏疾病、血小板聚集、癌症、移植、移植排斥或肺部损伤。
• PYRAZINE DERIVATIVES AND USE AS PI3K INHIBITORS
  申请人：Gaillard Pascale

  公开号：US20110312960A1

  公开（公告）日：2011-12-22

  The present invention is related to pyrazine derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.

  本发明涉及式（I）的吡嗪衍生物，特别是用于治疗和/或预防自身免疫性疾病和/或炎症性疾病、心血管疾病、神经退行性疾病、细菌或病毒感染、肾脏疾病、血小板聚集、癌症、移植、移植排斥或肺损伤。
• Pyrazine derivatives and use as PI3K inhibitors
  申请人：Merck Serono S.A.

  公开号：EP2351745A1

  公开（公告）日：2011-08-03

  The present invention is related to pyrazine derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.

  本发明涉及式（I）的吡嗪衍生物，特别是用于治疗和/或预防自身免疫性疾病和/或炎症性疾病、心血管疾病、神经退行性疾病、细菌或病毒感染、肾脏疾病、血小板聚集、癌症、移植、移植物排斥或肺损伤。
• PHOSPHATIDYLINOSITOL-3-KINASE P110 DELTA-TARGETED DRUGS IN THE TREATMENT OF CNS DISORDERS
  申请人：The U.S.A. As Represented By The Secretary, Department Of Health And Human Services

  公开号：EP2365810A2

  公开（公告）日：2011-09-21
• JP2009506015A
  申请人：——

  公开号：JP2009506015A

  公开（公告）日：2009-02-12