1-iodopropyl cyclohexyl carbonate | 103418-25-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: 1-iodopropyl cyclohexyl carbonate
• 英文别名: Cyclohexyl 1-iodopropyl carbonate
• CAS: 103418-25-3
• 化学式: C₁₀H₁₇IO₃
• 分子量: 312.148
• InChiKey: YRMKZAMDVOFBGY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-iodopropyl cyclohexyl carbonate 、 (2S)-2-[4-((1R,2S)-2-hydroxycyclopentylmethyl)phenyl]propionic acid 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 丙酮 为溶剂， 以1.054 g的产率得到1-cyclohexyloxycarbonyloxypropyl (2S)-2-[4-[[(1R,2S)-2-hydroxycyclopentyl]methyl]phenyl]propanoate
  参考文献：
  名称：

  ARYLPROPIONIC ACID DERIVATIVE, PHARMACEUTICAL COMPOSITION AND PREPARATION METHOD AND APPLICATION THEREOF

  摘要：

  提供了一种由式（I）表示的芳基丙酸衍生物，以及其制备方法和应用的制药组合物。该芳基丙酸衍生物具有良好的半衰期、药物动力学特性和体外稳定性，并且在制备成制剂后可以增强疗效并减少毒性，修复传统非甾体抗炎药常规使用、胃肠道副作用和患者依从性不佳等缺陷。

  公开号：

  US20220274911A1
• 作为产物：
  描述：

  1-chloropropyl cyclohexyl carbonate 生成 1-iodopropyl cyclohexyl carbonate
  参考文献：
  名称：

  ARYLPROPIONIC ACID DERIVATIVE, PHARMACEUTICAL COMPOSITION AND PREPARATION METHOD AND APPLICATION THEREOF

  摘要：

  提供了一种由式（I）表示的芳基丙酸衍生物，以及其制备方法和应用的制药组合物。该芳基丙酸衍生物具有良好的半衰期、药物动力学特性和体外稳定性，并且在制备成制剂后可以增强疗效并减少毒性，修复传统非甾体抗炎药常规使用、胃肠道副作用和患者依从性不佳等缺陷。

  公开号：

  US20220274911A1

文献信息

• Carbapenem derivatives
  申请人：Meiji Seika Kaisha, Ltd.

  公开号：US06310056B1

  公开（公告）日：2001-10-30

  The carbapenem derivatives represented by the following formula (I) is disclosed. These compounds have strong anti-bacterial activities against bacteria including methicillin resistant Staphylococcus aureus, penicillin resistant Streptococcus pneumoniae, Enterococci, influenza, and &bgr;-lactamase producing bacteria, and have high stabilities to DHP-1 wherein R1 represents hydrogen or methyl, either one of R2, R3, R4, or R5 represents the bond to the 2-position on the carbapenem ring, and the remaining three respectively represent hydrogen, halogen, nitro, cyano, alkyl, cycloalkyl, alkylthio, alkenyl, formyl, alkylcarbonyl, alkoxycarbonyl, aminosulfonyl, aryl carbonyl, aryl, carbamoyl, N-lower alkylcarbamoyl, N,N-di-lower alkylaminocarbonyl, lower alkoxyiminomethyl, or hydroxyiminomethyl, R6 is not present or represents alkyl, cycloalkyl, or alkenyl, and R is not present, or represents hydrogen or a group which may be metabolically hydrolyzed in the body, provided that when R6 is not present, R represents hydrogen or a group which may be metabolically hydrolyzed in the body, and when R6 is present, R is not present, and the compound forms an inner salt.

  披露了以下公式(I)表示的碳青霉烯衍生物。这些化合物对包括耐甲氧西林金黄色葡萄球菌、耐青霉素肺炎链球菌、肠球菌、流感嗜血杆菌和产生β-内酰胺酶的细菌具有强烈的抗菌活性，并且对DHP-1具有较高的稳定性 其中R1代表氢或甲基，R2、R3、R4或R5之一代表与碳青霉烯环2位的键，其余三个分别代表氢、卤素、硝基、氰基、烷基、环烷基、硫代烷基、烯基、甲酰基、烷基甲酰基、烷氧基甲酰基、氨基磺酰基、芳基甲酰基、芳基、甲酰氨基、N-低级烷基甲酰氨基、N，N-二低级烷基氨基甲酰基、低级烷氧基亚硝基甲基或羟基亚硝基甲基，R6不存在或代表烷基、环烷基或烯基，R不存在，或代表氢或可能在体内代谢水解的基团，前提是当R6不存在时，R代表氢或可能在体内代谢水解的基团，当R6存在时，R不存在，并且该化合物形成内盐。
• 이부프로펜 에스테르계 전구약물, 약학적 조성물 및 제조방법과 응용
  申请人：난징 헤론 파마슈티컬 사이언스 앤 테크놀로지 컴퍼니 리미티드

  公开号：KR20220024171A

  公开（公告）日：2022-03-03

  본 출원에서는 구조식 (1)로 표시되는 이부프로펜 에스테르계 전구약물, 그의 라세미체, 입체이성질체, 약학적으로 허용가능한 염 또는 용매화물, 또는 그의 약학적으로 허용가능한 염의 용매화물을 제공한다. 본 출원에서는 상기 화합물의 제조방법, 이를 포함한 약학적 조성물 및 비스테로이드성 항염증 약물 제조를 위한 응용을 더 제공한다. 상기 이부프로펜 에스테르계 전구약물을 포함하는 악학적 조성물을 지방 에멀젼 주사제로 제조할 수 있다. 상기 이부프로펜 에스테르계 전구약물은 양호한 안정성 및 양호한 약동학적 특성을 구비함으로써, 이부프로펜의 반감기가 짧고 안정성이 낮고 자극성 및 호환 등 측면에 존재하는 문제를 극복하였다. [구조식 (1)]

  本申请提供了标记为结构式（1）的伊布普罗芬酯前药、其拉丁体、立体异构体、药学上可接受的盐或溶剂化合物，或其药学上可接受的盐的溶剂化合物。本申请还提供了该化合物的制备方法，以及包括它的药学组合物和用于制备非类固醇抗炎药物的应用。含有伊布普罗芬酯前药的药学组合物可以制备为脂肪乳注射剂。由于伊布普罗芬酯前药具有良好的稳定性和良好的药动学特性，克服了伊布普罗芬的半衰期短、稳定性低、刺激性和相容性等方面存在的问题。【结构式（1）】
• IBUPROFEN ESTER PRODRUG, PHARMACEUTICAL COMPOSITION AND PREPARATION METHOD AND USE
  申请人：Nanjing Heron Pharmaceutical Science and Technology Co., Ltd.

  公开号：EP3984989A1

  公开（公告）日：2022-04-20

  Provided is an ibuprofen ester prodrug represented by Structural Formula (1), a racemate, stereoisomer or pharmaceutically acceptable salt or solvate thereof, or a solvate of a pharmaceutically acceptable salt thereof. Further provided are a method for preparing the compound, a pharmaceutical composition containing the compound, and an application of the compound in preparation of nonsteroidal anti-inflammatory drugs. The pharmaceutical composition containing the ibuprofen ester prodrug may be prepared into fat emulsion injection preparations. The ibuprofen ester prodrug has good stability and good pharmacokinetic properties and overcomes the problems of ibuprofen such as a short half-life, poor stability, irritation, and incompatibility.

  提供的是一种伊布普洛芬酯前药，其结构式表示为（1），可以是混合物、立体异构体或药学上可接受的盐或溶剂化物，或其药学上可接受的盐的溶剂化物。还提供了一种制备该化合物的方法，包含该化合物的制药组合物，以及该化合物在制备非甾体抗炎药方面的应用。含有伊布普洛芬酯前药的制药组合物可以制备成脂肪乳注射制剂。伊布普洛芬酯前药具有良好的稳定性和良好的药代动力学特性，克服了伊布普洛芬的问题，例如短半衰期、稳定性差、刺激性和不相容性。
• Novel carbapenem derivatives
  申请人：——

  公开号：US20030149016A1

  公开（公告）日：2003-08-07

  Disclosed is a novel carbapenem derivative having a substituted imidazo[5,1-b]thiazole group at the 2-position on the, carbapenem ring have high anti-microbial activities against &bgr;-lactamase producing bacteria, MRSA, resistant- Pseudomonas aeruginosa , PRSP, enterococci, and influenza, and high stabilities to DHP-1. According to the present invention, there is provided a compound represented by the formula (I), or a pharmacologically acceptable salt thereof or an ester at the 3-position on the carbapenem ring thereof: 1

  本发明公开了一种新型碳青霉烯衍生物，其在碳青霉烯环上的2位上具有取代咪唑[5,1-b]噻唑基团，对β-内酰胺酶产生的细菌、MRSA、耐药性假单胞菌、PRSP、肠球菌和流感病毒具有高抗菌活性，并对DHP-1具有高稳定性。根据本发明，提供了由式(I)表示的化合物，或其在碳青霉烯环上的3位处的药理学上可接受的盐或酯：1。
• NOVEL CARBAPENEM DERIVATIVES
  申请人：Meiji Seika Kaisha, Ltd.

  公开号：EP1101766A1

  公开（公告）日：2001-05-23

  Disclosed is a novel carbapenem derivative having a substituted imidazo[5,1-b]thiazole group at the 2-position on the carbapenem ring have high anti-microbial activities against β-lactamase producing bacteria, MRSA, resistant-Pseudomonas aeruginosa, PRSP, enterococci, and influenza, and high stabilities to DHP-1. According to the present invention, there is provided a compound represented by the formula (I), or a pharmacologically acceptable salt thereof or an ester at the 3-position on the carbapenem ring thereof:

  本发明公开了一种新型碳青霉烯类衍生物，该衍生物的碳青霉烯环上 2 位具有取代的咪唑并[5,1-b]噻唑基团，对产β-内酰胺酶细菌、MRSA、耐药铜绿假单胞菌、PRSP、肠球菌和流感具有高抗微生物活性，对 DHP-1 具有高稳定性。根据本发明，提供了一种由式（I）代表的化合物，或其药理学上可接受的盐，或其碳青霉烯环上 3 位的酯：