(5Z)-5-(3,4-dihydroxybenzylidene)-2-[(2,3-dimethylphenyl)amino]-1,3-thiazol-4(5H)-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: (5Z)-5-(3,4-dihydroxybenzylidene)-2-[(2,3-dimethylphenyl)amino]-1,3-thiazol-4(5H)-one
• 英文别名: (5Z)-5-[(3,4-dihydroxyphenyl)methylidene]-2-(2,3-dimethylphenyl)imino-1,3-thiazolidin-4-one
• 化学式: C₁₈H₁₆N₂O₃S
• 分子量: 340.4
• InChiKey: USTZKVKLINTJHZ-SXGWCWSVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  107
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Inhibiting G Protein Coupled Receptor 6 Kinase Polypeptides
  申请人：Mayo Foundation for Medical Educational and Research

  公开号：US20140309185A1

  公开（公告）日：2014-10-16

  This document relates to inhibitors of G protein coupled receptor 6 kinase (GRK6) polypeptides as well as methods and materials for using such inhibitors to treat hematological malignancies, inflammation diseases, and autoimmune disorders.

  这份文件涉及G蛋白偶联受体6激酶（GRK6）多肽的抑制剂，以及利用这些抑制剂治疗血液恶性肿瘤、炎症性疾病和自身免疫性疾病的方法和材料。
• Inhibiting G protein coupled receptor 6 kinase polypeptides
  申请人：Mayo Foundation for Medical Education and Research

  公开号：US10252984B2

  公开（公告）日：2019-04-09

  This document relates to inhibitors of G protein coupled receptor 6 kinase (GRK6) polypeptides as well as methods and materials for using such inhibitors to treat hematological malignancies, inflammation diseases, and autoimmune disorders.

  本文件涉及 G 蛋白偶联受体 6 激酶（GRK6）多肽的抑制剂以及使用这种抑制剂治疗血液恶性肿瘤、炎症疾病和自身免疫性疾病的方法和材料。
• [EN] INHIBITING G PROTEIN COUPLED RECEPTOR 6 KINASE POLYPEPTIDES<br/>[FR] INHIBITION DE POLYPEPTIDES DE RÉCEPTEURS 6 KINASES COUPLÉS À UNE PROTÉINE G
  申请人：MAYO FOUNDATION

  公开号：WO2013063458A2

  公开（公告）日：2013-05-02

  This document relates to inhibitors of G protein coupled receptor 6 kinase (GRK6) polypeptides as well as methods and materials for using such inhibitors to treat hematological malignancies, inflammation diseases, and autoimmune disorders.