N²-(2-methoxyethyl)-N²-methylpyridine-2,4,5-triamine | 1399181-26-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N²-(2-methoxyethyl)-N²-methylpyridine-2,4,5-triamine
• 英文别名: 2-N-(2-methoxyethyl)-2-N-methylpyridine-2,4,5-triamine；N2-(2-methoxyethyl)-N2-methyl-2,4,5-pyridinetriamine
• CAS: 1399181-26-0
• 化学式: C₉H₁₆N₄O
• 分子量: 196.252
• InChiKey: CFMOVYZWFPWVRM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  77.4
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N²-(2-methoxyethyl)-N²-methylpyridine-2,4,5-triamine 、 4-(1-(5-formyl-2,4-dimethylbenzoyl)piperidin-4-yl)benzonitrile 在 ammonium acetate 作用下， 以 乙醇 为溶剂， 以24%的产率得到4-(1-(5-(6-((2-methoxyethyl)(methyl)amino)-3H-imidazo[4,5-c]pyridin-2-yl)-2,4-dimethylbenzoyl)piperidin-4-yl)benzonitrile
  参考文献：
  名称：

  [EN] HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS
  [FR] MODULATEURS HÉTÉROCYCLIQUES DE LA SYNTHÈSE DES LIPIDES

  摘要：

  提供了一些脂肪酸合成调节剂。这些化合物可用于治疗由于调节脂肪酸合酶功能不当而表现出的紊乱的疾病，通过调节功能和/或脂肪酸合酶途径。提供了用于治疗此类疾病的方法，包括病毒感染，如丙型肝炎感染，癌症和代谢性疾病。

  公开号：

  WO2012122391A1

文献信息

• Heterocyclic Modulators of Lipid Synthesis
  申请人：Oslob Johan D.

  公开号：US20120264737A1

  公开（公告）日：2012-10-18

  Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders.

  提供了一些脂肪酸合成调节剂化合物。这些化合物可以通过调节功能和/或脂肪酸合成途径来治疗由脂肪酸合酶功能失调所表征的疾病。提供了治疗这些疾病的方法，包括病毒感染，如丙型肝炎感染，癌症和代谢性疾病。
• HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS
  申请人：3-V BIOSCIENCES, INC.

  公开号：US20140322355A1

  公开（公告）日：2014-10-30

  Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders.

  提供了一些脂肪酸合成调节剂化合物。这些化合物可以通过调节功能和/或脂肪酸合成途径来治疗特征为脂肪酸合成酶功能失调的疾病。提供了用于治疗这些疾病的方法，包括病毒感染（如丙型肝炎感染）、癌症和代谢性疾病。
• Heterocyclic modulators of lipid synthesis
  申请人：Sagimet Biosciences Inc.

  公开号：US11034690B2

  公开（公告）日：2021-06-15

  Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

  本研究提供了脂肪酸合成调节剂化合物。通过调节脂肪酸合成酶的功能和/或脂肪酸合成酶途径，这些化合物可用于治疗以脂肪酸合成酶功能失调为特征的疾病。提供了治疗此类疾病的方法，包括病毒感染，如丙型肝炎感染、癌症和代谢紊乱，如非酒精性脂肪性肝炎（NASH）。
• Imidazopyridine-Based Fatty Acid Synthase Inhibitors That Show Anti-HCV Activity and in Vivo Target Modulation
  作者：Johan D. Oslob、Russell J. Johnson、Haiying Cai、Shirley Q. Feng、Lily Hu、Yuko Kosaka、Julie Lai、Mohanram Sivaraja、Samnang Tep、Hanbiao Yang、Cristiana A. Zaharia、Marc J. Evanchik、Robert S. McDowell

  DOI：10.1021/ml300335r

  日期：2013.1.10

  Potent imidazopyridine-based inhibitors of fatty acid synthase (FASN) are described. The compounds are shown to have antiviral (HCV replicon) activities that track with their biochemical activities. The most potent analogue (compound 19) also inhibits rat FASN and inhibits de novo palmitate synthesis in vitro (cell-based) as well as in vivo.
• US8871790B2
  申请人：——

  公开号：US8871790B2

  公开（公告）日：2014-10-28