2R-1,2-diphenylethylenediamine | 1217528-63-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 2R-1,2-diphenylethylenediamine
• 英文别名: R-1,2-diphenylethylenediamine；(1r,2s)-1,2-Diphenylethylenediamine；(2R)-1,2-diphenylethane-1,2-diamine
• CAS: 1217528-63-6
• 化学式: C₁₄H₁₆N₂
• 分子量: 212.294
• InChiKey: PONXTPCRRASWKW-KWCCSABGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2R-1,2-diphenylethylenediamine 、 环氧乙烷 以77%的产率得到
  参考文献：
  名称：

  SHISHKIN, G. V.;NAUMENKO, I. I.;ANISIMOVA, I. L.;YUDINA, O. B.;STOROZHENK+, XIMIYA GETEROTSIKL. SOEDIN., 1982, N 1, 95-100

  摘要：

  DOI：

文献信息

• Chiral C2-symmetric biphenyls, their preparation and also metal complexes in which these ligands are present and their use as catalysts in chirogenic syntheses
  申请人：Peschko Christian

  公开号：US20050250951A1

  公开（公告）日：2005-11-10

  A new class of C 2 -symmetric biaryldiphosphines comprising a fused ring system (dioxacycle) which has at least seven ring atoms and can be varied synthetically. The biaryldiphosphines can be used as ligands for preparing metal complexes useful as catalysts in organic synthesis, and the dioxacycles can be varied to optimize reaction with specific substrates.

  一种新型的C2对称的双芳基二膦化合物，包括至少七个环原子的融合环系统（二氧环），可以在合成过程中进行变化。这些双芳基二膦化合物可以用作配体，用于制备金属配合物，这些金属配合物在有机合成中作为催化剂，而二氧环可以进行变化以优化与特定底物的反应。
• Main-group metal-based asymmetric catalysts and applications thereof
  申请人：——

  公开号：US20030187249A1

  公开（公告）日：2003-10-02

  The present invention relates to a method and catalysts for the stereoselective addition of a nucleophile to a reactive &pgr;-bond of a substrate. The chiral, non-racemic catalysts of the present invention constitute the first examples of catalysts for nucleophilic additions that comprise a main-group metal and a tri- or tetra-dentate ligand.

  本发明涉及一种方法和催化剂，用于对底物的活性π键进行立体选择性地加成亲核试剂。本发明的手性、非外消旋催化剂构成了首批包含主族金属和三或四齿配体的亲核加成催化剂的示例。
• Process for the preparation of nonracemic syn-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenyl -piperidin-1-yl)-1-propanol compounds
  申请人：DSM CATALYTICA PHARMACEUTICALS, INC.

  公开号：US20030144521A1

  公开（公告）日：2003-07-31

  The present invention provides a process for the preparation of a nonracemic diastereomer of 1-(4-benzoxy-phenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanol by hydrogenation of a corresponding nonracemic 1-(4-benzoxy-phenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanone using a catalyst system comprising ruthenium, a nonracemic diphosphine ligand, a bidentate amine ligand selected from amino-thioethers and achiral diamines, and a base.

  本发明提供了一种制备非外消旋对映体1-(4-苯氧基苯基)-2-(4-羟基-4-苯基哌啶-1-基)-1-丙醇的方法，通过使用催化剂体系对相应的非外消旋1-(4-苯氧基苯基)-2-(4-羟基-4-苯基哌啶-1-基)-1-丙酮进行加氢反应，所述催化剂体系包括钌、非外消旋二膦配体、从氨基硫醚和非手性二胺中选择的双齿胺配体以及碱。
• Synthesis of beta-elemene, intermediates thereto, analogues and uses thereof
  申请人：Huang Lan

  公开号：US20060014987A1

  公开（公告）日：2006-01-19

  The present invention provides convergent processes for preparing beta-elemene, and analogues thereof. Also provided are analogues related to beta-elemene and intermediates useful for preparing the same. The present invention further provides novel compositions based on analogues of beta-elemene and methods for the treatment of cancer, such as brain tumor, lung cancer, colorectal cancer, gastric intestional cancer, and stomach cancer.

  本发明提供了制备β-艾莫烯及其类似物的汇聚过程。还提供与β-艾莫烯相关的类似物和用于制备它们的中间体。本发明还提供了基于β-艾莫烯类似物的新型组合物和用于治疗癌症（如脑肿瘤、肺癌、结直肠癌、胃肠癌和胃癌）的方法。
• NOVEL CHIRAL METAL COMPLEX AND USE THEREOF FOR ANALYZING CHIRALITY OF CHARGED COMPOUND BY 1H NMR SPECTROSCOPY
  申请人：KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

  公开号：US20170052131A1

  公开（公告）日：2017-02-23

  Provided are novel ligand, a chiral metal complex including the same, and a use of the chiral metal complex for analyzing the chirality of a charged compound by 1 H NMR spectroscopy. The chiral metal complex of the present invention may be used as the chiral solvating agent to conveniently analyze the optical purity of charged compounds such as various amine derivatives, carboxylic acid derivatives, cyanohydrin derivatives and charged metal complexes by 1 H NMR spectroscopy.

  本发明提供了一种新型配体，包括该配体的手性金属配合物，以及利用该手性金属配合物通过1H NMR光谱分析带电化合物的手性的用途。本发明的手性金属配合物可用作手性溶剂化剂，方便地通过1H NMR光谱分析各种胺衍生物、羧酸衍生物、氰醇衍生物和带电金属配合物等带电化合物的光学纯度。