4,5-dihydro-N-(1,2,3,4-tetrahydro-1-naphthalenyl)-2-oxazolamine | 40520-31-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 4,5-dihydro-N-(1,2,3,4-tetrahydro-1-naphthalenyl)-2-oxazolamine
• 英文别名: N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1,3-oxazol-2-amine
• CAS: 40520-31-8
• 化学式: C₁₃H₁₆N₂O
• 分子量: 216.283
• InChiKey: FXNNPMSELIMMHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  33.6
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Indanyl- and Tetrahydronaphthyl-Amino-Azoline Compounds for Combating Animal Pests
  申请人：Kordes Markus

  公开号：US20080293569A1

  公开（公告）日：2008-11-27

  The present invention relates to Indanyl- and Tetrahydronaphthyl-amino-azoline compounds of formula I wherein the variables R 1 and R 2 are as defined in description. The invention relates also to methods of combating or controlling insects, arachnids or nematodes, to methods for protecting growing plants from attack or infestation by insects, arachnids or nematodes, to methods for the protection of seeds from soil insects and of the seedlings' roots and shoots from soil and foliar insects and to methods for treating, controlling, preventing or protecting animals against infestation or infection by parasites.

  本发明涉及公式I的Indanyl和Tetrahydronaphthyl-amino-azoline化合物，其中变量R1和R2如描述中所定义。本发明还涉及用于对抗或控制昆虫、蜘蛛或线虫的方法，用于保护生长中的植物免受昆虫、蜘蛛或线虫的攻击或侵染的方法，用于保护种子免受土壤昆虫和幼苗的根和茎免受土壤和叶面昆虫的侵染的方法，以及用于治疗、控制、预防或保护动物免受寄生虫感染或侵染的方法。
• CHEMICAL COMPOUNDS
  申请人：Luthy Christoph

  公开号：US20100280085A1

  公开（公告）日：2010-11-04

  The use of a compound of formula (I) wherein X is (i), (ii) or (iii), where the substituents have the meanings assigned to them in claim 1 , or compositions containing them in controlling insects, acarines, nematodes or molluscs. Novel compounds are also provided.

  使用式(I)中的化合物，其中X为(i)、(ii)或(iii)，其中取代基所赋予的含义如权利要求1所述，或含有这些化合物的组合物来控制昆虫、螨、线虫或软体动物。同时还提供了新的化合物。
• Insecticidal Substituted Amino Heterocyclic and Heteroaryl Derivatives
  申请人：Dixon John A.

  公开号：US20100137385A1

  公开（公告）日：2010-06-03

  Certain substituted amino heterocyclic and heteroaryl derivatives have provided unexpected insecticidal and acaricidal activity. These compounds are represented by formula (I): wherein R, R 1 , R 2 , R 3 , R 4 , A, B and Q are fully described herein. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula I, and optionally, an effective amount of at least one of an additional compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.

  某些取代氨基杂环和杂环基衍生物表现出意外的杀虫和杀螨活性。这些化合物由公式（I）表示：其中R，R1，R2，R3，R4，A，B和Q在此完全描述。此外，还公开了包含公式I中至少一种化合物的杀虫有效量和可选地至少一种额外化合物的有效量，并带有至少一种杀虫兼容载体的组合物；以及通过将上述组合物应用于存在或预计存在昆虫的地点来控制昆虫的方法。
• Substituted Azolin-2-yl-Amino Compounds
  申请人：Koradin Christopher

  公开号：US20100167925A1

  公开（公告）日：2010-07-01

  The present invention relates to azolin-2-yl-amino compounds of formulae (I. a) and (1.b) and their salts which are useful for combating animal pest, in particular arthropod and nematodes. The present invention also relates to a method for combating such pests and for protecting crops against infestation or infection by such pests. Furthermore, the present invention relates to veterinary compositions for combating animal pests. Formula (I.a), formula (I.b) wherein n is 0 to 4; X is S, O or NR 5 ; A is —C(R 6a )(R 6b )—, O, NR 7 , S, S(O) or S(O) 2 ; B is a bond Or CH 2 ; R 1 is H, CN, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 1 -C 6 -alkylcarbonyl, C 3 -C 6 -cycloalkyl, phenyl, benzyl, etc.; R 2a , R 2b are H, CN, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 1 -C 6 -alkylcarbonyl, (C 1 -C 6 -alkyl)-thiocarbonyl, C(O)NR a R b , C(S)NR a R b , (SO 2 )NR a R b , phenyl, benzyl, 5 or 6 membered heterocyclic ring etc.; or R 1 together with R 2a is C 3 -C 5 -alkandiyl; or R 1 together with R 2 are C(O); R 3a , R 3b , R 3c , R 3d are H, halogen, CN, C 1 -C 6 -alkyl, C 1 -C 6 -alkylamino, C 3 -C 6 -cycloalkyl, phenyl, benzyl, etc.; R 4a , R 4b are H, halogen, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, phenyl, benzyl, 5 or 6 membered hetaryl; or R 4a together with R b may also be ═O, ═NR C or ═CR d R e ; or R 2a together with R 4a may form a bridging bivalent radical.

  本发明涉及式（I.a）和（I.b）的噁唑啉-2-基氨基化合物及其盐，其对动物害虫，特别是节肢动物和线虫的防治具有用途。本发明还涉及一种用于防治此类害虫并保护作物免受此类害虫侵染或感染的方法。此外，本发明涉及用于防治动物害虫的兽医组合物。其中，式（I.a）和式（I.b）中，n为0至4；X为S，O或NR5；A为—C（R6a）（R6b）—，O，NR7，S，S（O）或S（O）2；B为键或CH2；R1为H，CN，C1-C6烷基，C2-C6烯基，C1-C6烷基羰基，C3-C6环烷基，苯基，苄基等；R2a，R2b为H，CN，C1-C6烷基，C2-C6烯基，C1-C6烷基羰基，（C1-C6烷基）硫代羰基，C（O）NRaRb，C（S）NRaRb，（SO2）NRaRb，苯基，苄基，5或6元杂环等；或R1与R2a一起为C3-C5烷二基；或R1与R2a一起为C（O）；R3a，R3b，R3c，R3d为H，卤素，CN，C1-C6烷基，C1-C6烷基氨基，C3-C6环烷基，苯基，苄基等；R4a，R4b为H，卤素，C1-C6烷基，C2-C6烯基，苯基，苄基，5或6元杂芳基；或R4a与Rb一起也可以是═O，═NR或═CRdRe；或R2a与R4a一起可以形成桥联的二价基团。
• Substituted amino-dihydrooxazoles, -thiazoles and -imidazoles, process for their preparation and pharmaceutical compositions containing them
  申请人：BEECHAM GROUP PLC

  公开号：EP0251453A2

  公开（公告）日：1988-01-07

  A compound of formula (I): or a pharmaceutically acceptable acid addition salt and/or a pharmaceutically acceptable solvate thereof, wherein R1 and R2 each independently represents a hydrogen or halogen atom, a C1-6 alkyl or C1-6 alkoxy group; R3 and R4 each independently represents a hydrogen atom or a C1-6 alkyl group; X represents a bond or a moiety CHR5 wherein R5 is a group R3; and Z represents 0 or NH; a process for preparing such compounds, a pharmaceutical composition containing such compounds, and the use of such compounds and compositions in medicine.

  式(I)化合物 或其药学上可接受的酸加成盐和/或药学上可接受的溶液，其中 R1 和 R2 各自独立地代表氢原子或卤素原子、C1-6 烷基或 C1-6 烷氧基； R3 和 R4 各自独立地代表氢原子或 C1-6 烷基； X 代表键或分子 CHR5，其中 R5 是基团 R3；以及 Z代表0或NH；制备此类化合物的工艺、含有此类化合物的药物组合物，以及此类化合物和组合物在医药中的用途。