N-[2-乙基-4-氧代-8-(三氟甲氧基)-3(4H)-喹唑啉基]-2-(3-氟苯基)乙酰胺 | 848027-37-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 中文名称: N-[2-乙基-4-氧代-8-(三氟甲氧基)-3(4H)-喹唑啉基]-2-(3-氟苯基)乙酰胺
• 英文名称: N-(2-Ethyl-4-oxo-8-(trifluoromethoxy)quinazolin-3(4H)-yl)-2-(3-fluorophenyl)acetamide
• 英文别名: N-[2-ethyl-4-oxo-8-(trifluoromethoxy)quinazolin-3-yl]-2-(3-fluorophenyl)acetamide
• CAS: 848027-37-2
• 化学式: C₁₉H₁₅F₄N₃O₃
• 分子量: 409.3
• InChiKey: LJANVIBDHLJBJP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  71
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• FUSED RING HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS
  申请人：McNaughton-Smith Grant Andrew

  公开号：US20100273784A1

  公开（公告）日：2010-10-28

  Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides quinazolinone, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders (e.g., migraine, ataxia, Parkinson's disease, bipolar disorders, trigeminal neuralgia, spasticity, mood disorders, brain tumors, psychotic disorders, myokymia, seizures, epilepsy, hearing and vision loss, Alzheimer's disease, age-related memory loss, learning deficiencies, anxiety and motor neuron diseases, maintaining bladder control or treating urinary incontinence) and as neuroprotective agents (e.g., to prevent stroke and the like) by modulating potassium channels associated with the onset or recurrence of the indicated conditions.
• US8329713B2
  申请人：——

  公开号：US8329713B2

  公开（公告）日：2012-12-11