2-amino-4-(3-chlorophenyl)-5-oxo-5H-chromeno[4,3-b]pyridine-3-carbonitrile | 1430060-59-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2-amino-4-(3-chlorophenyl)-5-oxo-5H-chromeno[4,3-b]pyridine-3-carbonitrile
• 英文别名: 2-amino-4-(3-chlorophenyl)-5-oxo-5H-chromeno[4,3-b]pyridin-3-yl cyanide；2-Amino-4-(3-chlorophenyl)-5-oxochromeno[4,3-b]pyridine-3-carbonitrile；2-amino-4-(3-chlorophenyl)-5-oxochromeno[4,3-b]pyridine-3-carbonitrile
• CAS: 1430060-59-5
• 化学式: C₁₉H₁₀ClN₃O₂
• 分子量: 347.76
• InChiKey: QJJRVVTUJHCUJM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  25
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  89
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-氯苯甲醛 以 甲醇 、 水 为溶剂， 反应 0.33h， 生成 2-amino-4-(3-chlorophenyl)-5-oxo-5H-chromeno[4,3-b]pyridine-3-carbonitrile
  参考文献：
  名称：

  Solvent-free synthesis of novel 5-oxo-5H-chromeno[4,3-b]pyridine derivatives

  摘要：

  An efficient and simple method for the synthesis of new 5-oxo-5H-chromeno[4,3-b]pyridine derivatives via Michael addition of 4-aminocoumarin to arylidenemalononitrile for 20 min at 150A degrees C without any solvent is proposed. The advantages of this procedure are mild reaction conditions, high yields of products, and operational simplicity.

  DOI：

  10.1007/s10593-013-1217-1

文献信息

• Immobilized TiO₂ nanoparticles on carbon nanotubes: an efficient heterogeneous catalyst for the synthesis of chromeno[<i>b</i>]pyridine derivatives under ultrasonic irradiation
  作者：Shahrzad Abdolmohammadi、Behrooz Mirza、Esmail Vessally

  DOI：10.1039/c9ra09031b

  日期：——

  A new protocol for the synthesis of chromeno[b]pyridine derivatives is described via a three-component reaction of 4-aminocoumarin, aromatic aldehydes and malononitrile catalyzed by TiO2 nanoparticles immobilized on carbon nanotubes (TiO2-CNTs) as an efficient heterogeneous catalyst under ultrasonic irradiation in water. The sustainable and economic benefits of the protocol are the high yields of products

  描述了通过4-氨基香豆素、芳香醛和丙二腈的三组分反应合成色烯[ b ]吡啶衍生物的新方案，该反应由固定在碳纳米管 (TiO 2 -CNT) 上的 TiO 2纳米粒子作为高效多相催化剂催化在水中超声波照射下。该方案的可持续和经济效益在于产品收率高、反应时间短、后处理程序简单以及使用无毒且可重复使用的催化剂。
• Solvent-free synthesis of novel 5-oxo-5H-chromeno[4,3-b]pyridine derivatives
  作者：R. Motamedi

  DOI：10.1007/s10593-013-1217-1

  日期：2013.3

  An efficient and simple method for the synthesis of new 5-oxo-5H-chromeno[4,3-b]pyridine derivatives via Michael addition of 4-aminocoumarin to arylidenemalononitrile for 20 min at 150A degrees C without any solvent is proposed. The advantages of this procedure are mild reaction conditions, high yields of products, and operational simplicity.