5-(2-methoxy-4-(trifluoromethyl)phenyl)-4-methyl-1,2,3,4-tetrahydroisoquinoline | 1454667-51-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 5-(2-methoxy-4-(trifluoromethyl)phenyl)-4-methyl-1,2,3,4-tetrahydroisoquinoline
• 英文别名: Racemic 5-(2-methoxy-4-(trifluoromethyl)phenyl)-4-methyl-1,2,3,4-tetrahydroisoquinoline；5-[2-methoxy-4-(trifluoromethyl)phenyl]-4-methyl-1,2,3,4-tetrahydroisoquinoline
• CAS: 1454667-51-6
• 化学式: C₁₈H₁₈F₃NO
• 分子量: 321.342
• InChiKey: HWHVRYSRCVHTEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  5-溴-4-甲基异喹啉 、 2-甲氧基-4-(三氟甲基)苯基硼酸 在 potassium phosphate 、 二氯双[二叔丁基-(4-二甲基氨基苯基)膦]钯(II) 、 platinum(IV) oxide 、 氢气 、 三氟乙酸 作用下， 以 1,4-二氧六环 、 水 、 甲醇 为溶剂， 80.0 ℃ 、310.27 kPa 条件下， 以1.81 g的产率得到5-(2-methoxy-4-(trifluoromethyl)phenyl)-4-methyl-1,2,3,4-tetrahydroisoquinoline
  参考文献：
  名称：

  [EN] SULFAMIDE SODIUM CHANNEL INHIBITORS
  [FR] INHIBITEURS SULFAMIDES DES CANAUX DE SODIUM

  摘要：

  本发明提供了式I的化合物或其药学上可接受的盐，这些化合物是电压门控钠通道的抑制剂，特别是Nav 1.7。这些化合物对于治疗通过抑制钠通道可治疗的疾病，如疼痛障碍，是有用的。还提供了含有本发明化合物的药物组合物。

  公开号：

  WO2013134518A1

文献信息

• Sulfamide sodium channel inhibitors
  申请人：AMGEN INC.

  公开号：US09051311B2

  公开（公告）日：2015-06-09

  The present invention provides compounds of Formula I, or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav 1.7. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders. Also provided are pharmaceutical compositions containing compounds of the present invention.

  本发明提供了公式I的化合物或其药学上可接受的盐，它们是电压门控钠通道的抑制剂，特别是Nav 1.7。这些化合物可用于治疗通过抑制钠通道可治疗的疾病，如疼痛性疾病。本发明还提供了含有本发明化合物的药物组合物。
• SULFAMIDE SODIUM CHANNEL INHIBITORS
  申请人：AMGEN INC.

  公开号：US20150018352A1

  公开（公告）日：2015-01-15

  The present invention provides compounds of Formula I, or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav 1.7. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders. Also provided are pharmaceutical compositions containing compounds of the present invention.

  本发明提供了I式化合物或其药学上可接受的盐，它们是电压门控钠通道的抑制剂，特别是Nav 1.7。这些化合物对于治疗可通过钠通道抑制治疗的疾病如疼痛障碍非常有用。还提供了包含本发明化合物的制药组合物。
• US9051311B2
  申请人：——

  公开号：US9051311B2

  公开（公告）日：2015-06-09
• [EN] A METHOD FOR TIERED PRODUCTION OF BIOBASED CHEMICALS AND BIOFUELS FROM LIGNIN<br/>[FR] PROCÉDÉ DE PRODUCTION ÉTAGÉE DE BIOPRODUITS CHIMIQUES ET DE BIOCOMBUSTIBLES À PARTIR DE LIGNINE
  申请人：VERTICHEM CORP

  公开号：WO2013134756A1

  公开（公告）日：2013-09-12

  The present invention is directed generally to a method of production of value-added, biobased chemicals from lignin sources, including waste lignin. A method of using a depolymerization of lignin to create a tiered production of biobased aromatic chemicals and biofuels is also described herein. The method described herein may also allow for the selective production of the biobased aromatic chemicals and biofuels. Additionally, a reduction of waste products may also be provided from the present method.
• [EN] METHOD FOR SELECTIVE PRODUCTION OF BIOBASED CHEMICALS AND BIOFUELS FROM PLANT LIGNIN<br/>[FR] PROCÉDÉ POUR LA PRODUCTION SÉLECTIVE DE PRODUITS BIOCHIMIQUES ET DE BIOCOMBUSTIBLES À PARTIR DE LIGNINE VÉGÉTALE
  申请人：VERTICHEM CORP

  公开号：WO2013173332A1

  公开（公告）日：2013-11-21

  The present invention is directed generally to a method of production of biobased chemicals, biofuels, and lignin residues from lignin sources, including waste lignin. This method may allow for selectively producing biobased chemicals, biofuels, and lignin residues from lignin sources using certain processing methods. The methods for production of these biobased chemicals, biofuels, and lignin residues may be provided by chemical-induced processing, catalytic oxidative lignin depolymerisation processing, and catalytic hydroprocessing. Further, the catalytic hydroprocessing from processes including catalytic reduction processing, catalytic hydrodeoxygenation processing, and/or catalytic/dehydrogenation processing may also be used. The method described herein also provides a means in which waste from the process(es) may be reduced and/or recycled.