4-(Propan-2-ylsulfonyl)tetrahydrothiophene-3-ol 1,1-dioxide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫杂环戊烷
• 英文名称: 4-(Propan-2-ylsulfonyl)tetrahydrothiophene-3-ol 1,1-dioxide
• 英文别名: 1,1-dioxo-4-propan-2-ylsulfonylthiolan-3-ol
• 化学式: C₇H₁₄O₅S₂
• 分子量: 242.3
• InChiKey: OFWLWGGFHSWYEN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  105
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• N-phenyl-carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
  申请人：JANSSEN SCIENCES IRELAND UC

  公开号：US10398677B2

  公开（公告）日：2019-09-03

  Inhibitors of HBV replication of Formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X, R1, R2, R3 and R4 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.

  式 (I) 的 HBV 复制抑制剂 包括立体化学异构体形式及其盐类、水合物、溶液，其中 X、R1、R2、R3 和 R4 具有本文所定义的含义。 本发明还涉及制备所述化合物的工艺、含有这些化合物的药物组合物以及它们在 HBV 治疗中单独或与其他 HBV 抑制剂联合使用的情况。
• N-PHENYL-CARBOXAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B
  申请人：JANSSEN SCIENCES IRELAND UC,

  公开号：US20180153857A1

  公开（公告）日：2018-06-07

  Inhibitors of HBV replication of Formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X, R 1 , R 2 , R 3 and R 4 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
• US9895349B2
  申请人：——

  公开号：US9895349B2

  公开（公告）日：2018-02-20