(methoxymethyl)urea | 13824-21-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: (methoxymethyl)urea
• 英文别名: Methoxymethyl-harnstoff；1-(Methoxymethyl)urea；methoxymethylurea
• CAS: 13824-21-0
• 化学式: C₃H₈N₂O₂
• 分子量: 104.109
• InChiKey: HJYNGRZUBXMFGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  64.4
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (methoxymethyl)urea 、 溶剂黄146 生成 聚合甲醛
  参考文献：
  名称：

  278.脲醛缩聚反应。第一部分甲氧基甲基脲水解的动力学

  摘要：

  DOI：

  10.1039/jr9570001446
• 作为产物：
  描述：

  甲醇 、 羟甲基脲 在 盐酸 作用下， 反应 0.17h， 生成 (methoxymethyl)urea
  参考文献：
  名称：

  The Formation Pathway of 3,5-Bis(methoxymethyl)perhydro-1,3,5-oxadiazin-4-one

  摘要：

  对尿素及其甲基衍生物与甲醛的反应的研究阐明了3,5-双(甲氧基甲基)全氢-1,3,5-氧二嗪-4-酮的形成途径。1) 随着甲醛分子数量的增加，尿素与甲醛的加成反应变得越来越困难，这可能是由于羟甲基的立体位阻造成的。2) 3,5-双(甲氧基甲基)全氢-1,3,5-氧二嗪-4-酮被认为是通过三(羟甲基)脲和3-(羟甲基)全氢-1,3,5-氧二嗪-4-酮从尿素中衍生出来的，而不是通过四(羟甲基)脲或全氢-1,3,5-氧二嗪-4-酮。

  DOI：

  10.1246/bcsj.62.1930

文献信息

• Kadowaki, Bulletin of the Chemical Society of Japan, 1936, vol. 11, p. 253,256
  作者：Kadowaki

  DOI：——

  日期：——
• Monoethers of dimethylol urea and process for making same
  申请人：DU PONT

  公开号：US02247419A1

  公开（公告）日：1941-07-01
• Cortistatin, but not somatostatin, binds to growth hormone secretagogue (GHS) receptors of human pituitary gland
  作者：R. Deghenghi、M. Papotti、E. Ghigo、G. Muccioli

  DOI：10.1007/bf03343800

  日期：2001.1

  Antagonism between GH secretagogues (GHS) and somatostatin (SRIH) has been postulated and demonstrated, but SRIH does not bind to GHS receptors (GHS-R) and potent synthetic peptidyl GHS (GHRP6, hexarelin) do not displace radiolabeled SRIH from its receptors, However, non-natural SRIH octapeptide agonists (mainly lanreotide and vapreotide) displace I-125-Tyr-Ala-hexarelin from pituitary binding sites suggesting that an endogenous factor related to SRIH might exist and interact with GHS-R, Our aims were to investigate the ability of different SRIH-like peptides such as various SRIH fragments (SRIH 3-14, SRIH 7-14, SRIH 3-10, SRIH 7-10, SRIH 2-9) and a natural neuropeptide that shows a high structural homology with SRIH such as cortistatin-14 (CST) to compete with I-125-Tyr-Ala-hexarelin for human pituitary binding sites and to compare their binding affinity with that of hexarelin and ghrelin, a gastric-derived peptidyl GHS that has been proposed as a natural ligand of GHS-R, While the binding of I-125-Tyr-Ala-hexarelin to pituitary membranes was completely displaced by unlabelled hexarelin, ghrelin and CST, none of the SRIH fragments tested inhibited this binding, Ghrelin and CST exhibited a similar affinity (4.6-5.4 x 10(-7) mol/l) for the binding while hexarelin was more effective by about four orders of magnitude in displacing I-125-Tyr-Ala-hexarelin. Our data demonstrate for the first time that cortistatin, a natural peptide related to SRIH, binds to GHS-R and suggest that this factor may play a role in modulating the activity of these receptors. (C) 2001, Editrice Kurtis.