2-ethyl-7-(phenylmethyl)-2,7-diazaspiro<4.4>nonane-1,3,8-trione | 91189-29-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂螺环衍生物
• 英文名称: 2-ethyl-7-(phenylmethyl)-2,7-diazaspiro<4.4>nonane-1,3,8-trione
• 英文别名: 2-ethyl-7-(phenylmethyl)-2,7-diazaspiro[4.4]nonane-1,3,8-trione；2-ethyl-7-benzyl-2,7-diazaspiro[4.4]nonane-1,3,8-trione；2,7-Diazaspiro[4.4]nonane-1,3,8-trione, 2-ethyl-7-(phenylmethyl)-；7-benzyl-2-ethyl-2,7-diazaspiro[4.4]nonane-1,3,8-trione
• CAS: 91189-29-6
• 化学式: C₁₆H₁₈N₂O₃
• 分子量: 286.331
• InChiKey: BUTAOLSBUJKPHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  57.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-ethyl-7-(phenylmethyl)-2,7-diazaspiro<4.4>nonane-1,3,8-trione 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 生成 2-乙基-7-苄基-2,7-二氮杂螺[4.4]壬烷
  参考文献：
  名称：

  Quinolone antibacterial agents substituted at the 7-position with spiroamines. Synthesis and structure-activity relationships

  摘要：

  A series of fluoroquinolone antibacterials having the 7-position (10-position of pyridobenzoxazines) substituted with 2,7-diazaspiro[4.4]nonane (4b), 1,7-diazaspiro[4.4]nonane (5a), or 2,8-diazaspiro[5.5]undecane (6b) was prepared, and their biological activities were compared with piperazine and pyrrolidine substituted analogues. Most exhibited potent Gram-positive and Gram-negative activity, especially when side chain 4b was N-alkylated.

  DOI：

  10.1021/jm00170a035
• 作为产物：
  描述：

  triethyl 2-cyano-1,2,3-propanetricarboxylate 在 钴 sodium hydroxide 、 氢气 、 sodium hydride 、 三乙胺 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 25.0~230.0 ℃ 、37.23 MPa 条件下， 反应 30.67h， 生成 2-ethyl-7-(phenylmethyl)-2,7-diazaspiro<4.4>nonane-1,3,8-trione
  参考文献：
  名称：

  Quinolone antibacterial agents substituted at the 7-position with spiroamines. Synthesis and structure-activity relationships

  摘要：

  A series of fluoroquinolone antibacterials having the 7-position (10-position of pyridobenzoxazines) substituted with 2,7-diazaspiro[4.4]nonane (4b), 1,7-diazaspiro[4.4]nonane (5a), or 2,8-diazaspiro[5.5]undecane (6b) was prepared, and their biological activities were compared with piperazine and pyrrolidine substituted analogues. Most exhibited potent Gram-positive and Gram-negative activity, especially when side chain 4b was N-alkylated.

  DOI：

  10.1021/jm00170a035

文献信息

• Antibacterial agents
  申请人：Warner-Lambert Co.

  公开号：US04638067A1

  公开（公告）日：1987-01-20

  Novel naphthyridine-, quinoline- and benzoxazine-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.

  描述了新型萘啉基、喹啉基和苯并噁嗪基羧酸作为抗菌剂，以及它们的制造、配方和用于治疗细菌感染的方法，包括用于制造抗菌剂的某些新型中间体的描述。
• 4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial
  申请人：Warner-Lambert Company

  公开号：US04822801A1

  公开（公告）日：1989-04-18

  Novel naphthyridine-, quinoline- and benzoxazinecarboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.

  描述了新型萘啉基、喹啉基和苯并噁嗪羧酸作为抗菌剂的小说，以及它们的制造、配方和用于治疗细菌感染的方法，包括用于制造抗菌剂的某些新型中间体的描述。
• Antibacterial agents III
  申请人：Warner-Lambert Company

  公开号：US04604401A1

  公开（公告）日：1986-08-05

  Novel 1-amino-naphthyridine- and quinoline-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections.

  描述了作为抗菌剂的新型1-氨基萘啶和喹啉羧酸，以及它们的制备、配方和用于治疗细菌感染的方法。
• Antibacterial agents - II
  申请人：Warner-Lambert Company

  公开号：US05097032A1

  公开（公告）日：1992-03-17

  Novel naphthyridine-, quinoline- and benzoxazinecarboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.

  本文描述了新型萘啶、喹啉和苯并噁嗪羧酸作为抗菌剂，以及其制备、配方和治疗细菌感染的使用方法，包括制备抗菌剂所使用的某些新型中间体的描述。
• 7-Substituted-6-fluoro-8-substituted-1,4-dihydro-1-methylamino-4-oxo-3-quinolinecarboxylic acids; 7-substituted-6-fluoro-1,4-dihydro-1-methylamino-4-oxo-3-naphthyridine carboxylic acids; derivatives thereof; and processes for producing the compounds
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0169710A2

  公开（公告）日：1986-01-29

  Novel 1-amino-naphthyridine- and quinoline-carboxylic acids of formula wherein Z is as antibacterial agents are described as well as methods for their manufacture and formulations comprising the compounds.

  式中的新型 1-氨基萘啶和喹啉羧酸 其中 Z 为 描述了作为抗菌剂的新型 1-氨基萘啶和喹啉羧酸及其制造方法和包含这些化合物的制剂。