[1-(1-Phenylethyl)aziridin-2-yl]methanol

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: [1-(1-Phenylethyl)aziridin-2-yl]methanol
• 化学式: C₁₁H₁₅NO
• 分子量: 177.24
• InChiKey: BMEHDCBKAUDFBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  23.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Mitotic Kinesin Inhibitors
  申请人：Garbaccio Robert M.

  公开号：US20080234281A1

  公开（公告）日：2008-09-25

  The present invention relates to N-substituted benzylic aniline derivatives that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also relates to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

  本发明涉及用于治疗细胞增殖性疾病、治疗与KSP肌动蛋白活性相关的疾病以及抑制KSP肌动蛋白的N-取代苯基苯胺衍生物。本发明还涉及包含这些化合物的组合物以及使用它们治疗哺乳动物癌症的方法。
• METHODS OF USING AS ANALGESICS 1-BENZYL-1-HYDROXY-2,3-DIAMINO-PROPYL AMINES, 3-BENZYL-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES AND RELATED COMPOUNDS
  申请人：Leblond Bertrand

  公开号：US20090088433A1

  公开（公告）日：2009-04-02

  The compounds shown by the structural formulas below have analgesic effect and are used in compositions and methods for treating mammal in need of such treatment.

  下面结构式所示的化合物具有镇痛作用，用于治疗需要此类治疗的哺乳动物的组合物和方法中。
• METHODS FOR TREATING COGNITIVE DISORDERS USING 1-BENZYL-1-HYDROXY-2,3-DIAMINO-PROPYL AMINES, 3-BENZYL-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES AND RELATED COMPOUNDS
  申请人：Donello John E.

  公开号：US20100190792A1

  公开（公告）日：2010-07-29

  Disclosed herein are methods of treating a patient suffering from a cognitive disorder using the following compounds (I, II, III, IV, V, VI, VII, VIII, IX, X, XI, XII, XIII).

  本文披露了使用以下化合物（I、II、III、IV、V、VI、VII、VIII、IX、X、XI、XII、XIII）治疗患有认知障碍的患者的方法。
• METHODS OF USING AS ANALGESICS 1-BENZYL-1-HYDROXY-2, 3-DIAMINO-PROPYL AMINES, 3-BENZYL-3-HYRDROXY-2-AMINO-PROPIONIC ACID AMIDES AND RELATED COMPOUNDS
  申请人：Leblond Bertrand

  公开号：US20120225881A1

  公开（公告）日：2012-09-06

  The compounds shown by the structural formulas below have analgesic effect and are used in compositions and methods for treating mammal in need of such treatment.

  以下结构式所示的化合物具有镇痛作用，并用于治疗需要此类治疗的哺乳动物的组合物和方法。
• Pharmaceutical compositions having an analgesic effect and containing 1-benzyl-1-hydroxy-2,3-diamino-propyl amines, 3-benzyl-3-hydroxy-2-amino propionic acid amides or related compounds
  申请人：Allergan, Inc.

  公开号：EP2198864A1

  公开（公告）日：2010-06-23

  The present invention relates to pharmaceutical compositions having an analgesic effect and containing 1-benzyl-1-hydroxy-2,3-diamino-propyl amines, 3-benzyl-3-hydroxy-2-amino-propionic acid amides or related compounds.

  本发明涉及具有镇痛效果并含有 1-苄基-1-羟基-2,3-二氨基丙胺、3-苄基-3-羟基-2-氨基丙酸酰胺或相关化合物的药物组合物。