8-chloro-1,2-dimethoxy-5-(2-piperidin-1-yl)ethyldibenzo-[cd,f]indole-4(5H)-one | 1144526-82-8

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 马兜铃内酰胺
• 英文名称: 8-chloro-1,2-dimethoxy-5-(2-piperidin-1-yl)ethyldibenzo-[cd,f]indole-4(5H)-one
• 英文别名: 8-chloro-1,2-dimethoxy-5-(2-(piperidin-1-yl)ethyl)dibenzo[cd,f]indol-4(5H)-one；5-Chloro-14,15-dimethoxy-10-[2-(1-piperidyl)ethyl]-10-azatetracyclo[7.6.1.02,7.012,16]hexadeca-1(15),2(7),3,5,8,12(16),13-heptaen-11-one；5-chloro-14,15-dimethoxy-10-(2-piperidin-1-ylethyl)-10-azatetracyclo[7.6.1.02,7.012,16]hexadeca-1,3,5,7,9(16),12,14-heptaen-11-one
• CAS: 1144526-82-8
• 化学式: C₂₄H₂₅ClN₂O₃
• 分子量: 424.927
• InChiKey: MQOLTEUFMYEYDH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  42
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-氯-2-醛基苯硼酸 、 4-bromo-5,6-dimethoxy-2-(2-(piperidin-1-yl)ethyl)isoindolin-1-one 在 四(三苯基膦)钯 、 caesium carbonate 作用下， 以 乙醇 、 甲苯 为溶剂， 反应 0.17h， 以47%的产率得到8-chloro-1,2-dimethoxy-5-(2-piperidin-1-yl)ethyldibenzo-[cd,f]indole-4(5H)-one
  参考文献：
  名称：

  Synthesis of aristolactam analogues and evaluation of their antitumor activity

  摘要：

  A series of natural aristolactams and their analogues have been prepared and evaluated for antitumor activity against human cancer cells, including multi-drug resistant cell lines. Naturally occurring aristolactams, such as aristolactam BII (cepharanone B), aristolactam BIII, aristolactam FI (piperolactam A), N-methyl piperolactam A, and sauristolactam showed moderate antitumor activities in selected cell lines. However, several synthetic aristolactam derivatives exhibited potent antitumor activities against a broad array of cancer cell lines with GI(50) values in the submicromolar range. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.04.020