3-imidazol-1-yl-2,2-dimethyl-3-(4-phenylaminophenyl)propionic acid | 1391048-42-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: 3-imidazol-1-yl-2,2-dimethyl-3-(4-phenylaminophenyl)propionic acid
• 英文别名: 3-(4-Anilinophenyl)-3-imidazol-1-yl-2,2-dimethylpropanoic acid；3-(4-anilinophenyl)-3-imidazol-1-yl-2,2-dimethylpropanoic acid
• CAS: 1391048-42-2
• 化学式: C₂₀H₂₁N₃O₂
• 分子量: 335.406
• InChiKey: KKRDUARDBIREMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  67.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-(4-aminophenyl)-3-hydroxy-2,2-dimethylpropionic acid methyl ester 在 吡啶 、 copper diacetate 、 N,N'-羰基二咪唑 、 lithium hydroxide 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 水 、 乙腈 为溶剂， 反应 50.0h， 生成 3-imidazol-1-yl-2,2-dimethyl-3-(4-phenylaminophenyl)propionic acid
  参考文献：
  名称：

  基于3-（1 H-咪唑-和三唑-1-基）-2,2-二甲基-3-（4-（苯氨基）苯基）丙基支架的新型视黄酸4-羟化酶（CYP26）抑制剂

  摘要：

  维甲酸（RA）是维生素A的生物活性代谢物，在医学上用于治疗过度增生性疾病，包括皮肤病和癌症。RA的抗增殖作用以及毒性和对RA治疗产生抗药性的局限性已得到充分证明。RA代谢抑制剂（RAMBAs或CYP26抑制剂）作为在过度增殖性疾病中增强内源性视黄酸水平的替代方法，引起了越来越多的关注。新型3-（1 H描述了在MCF-7 CYP26A1微粒体测定中的-咪唑-和三唑-1-基）-2,2-二甲基-3-（4-（苯基氨基）苯基）丙基衍生物。最有前途的抑制剂2,2-二甲基-3-（4-（苯基氨基）苯基）-3-（1 H -1,2,4-三唑-1-基）丙酸酯（6）的IC 50为13 nM（与标准Liarozole IC 50 540 nM和R116010 IC 50 10 nM相比），并使用一组CYP进一步评估CYP选择性，发现CYP26的选择性> 100倍，而观察到的CYP1A2、2C9和2D6则为15倍与C

  DOI：

  10.1016/j.bmc.2012.05.076

文献信息

• IMIDAZOLE COMPOUND, METAL SURFACE TREATMENT LIQUID, METAL SURFACE TREATMENT METHOD, AND LAMINATE PRODUCTION METHOD
  申请人：TOKYO OHKA KOGYO CO., LTD.

  公开号：US20170247334A1

  公开（公告）日：2017-08-31

  A novel imidazole compound that yields a surface treatment liquid that is very effective at suppressing migration and oxidation of a wiring surface; a metal surface treatment liquid that contains the imidazole compound; a metal surface treatment method that uses the metal surface treatment liquid; and a laminate production method that uses the surface treatment liquid. A metal is surface-treated using the surface treatment liquid which includes a saturated fatty acid or a saturated fatty acid ester of a specific structure, in which a prescribed position is substituted by an aromatic group of a prescribed structure and an imidazolyl group that may have a substituent group.

  一种新型咪唑化合物，可产生一种表面处理液，该液非常有效地抑制导线表面的迁移和氧化；一种含有咪唑化合物的金属表面处理液；一种使用金属表面处理液的金属表面处理方法；以及一种使用表面处理液的层压板生产方法。使用包含饱和脂肪酸或饱和脂肪酸酯的表面处理液对金属进行表面处理，其中，预定位置被预定结构的芳基取代，并且可能带有取代基的咪唑基。
• CURABLE COMPOSITION
  申请人：Tokyo Ohka Kogyo Co., Ltd.

  公开号：EP3228641A1

  公开（公告）日：2017-10-11

  Provided are: a curable composition that can be cured at low temperature in a short time regardless of the type of epoxy compound that is mixed therewith, and has a long pot life; an adhesive comprising said curable composition; a method for producing a fiber-reinforced composite material that uses the curable composition; and a fiber-reinforced composite material containing a matrix comprising the curable composition. Furthermore, the present invention provides a curing agent mixture composition that can be cured at low temperature and in a short time, and provides the curable composition with a long pot life. Furthermore, provided is a curing agent mixture composition that can be cured at low temperature and in a short time, and provides the curable composition with a long pot life. An epoxy compound (A) and an imidazole compound (B) having a specific structure are blended in with the curable composition. In addition, the imidazole compound (B) having a specific structure and at least one type of crosslinking agent (C) selected from the group comprising a polyvalent amide compound and a polyvalent carboxylic acid anhydride are blended in with the curing agent mixture composition.

  本发明提供了：一种可固化组合物，无论与哪种环氧化合物混合，都能在短时间内低温固化，并具有较长的固化寿命；一种包含所述可固化组合物的粘合剂；一种使用该可固化组合物生产纤维增强复合材料的方法；以及一种含有包含该可固化组合物的基体的纤维增强复合材料。此外，本发明还提供了一种固化剂混合物组合物，可在低温和短时间内固化，并使固化组合物具有较长的固化寿命。此外，本发明还提供了一种固化剂混合物组合物，可在低温和短时间内固化，并使固化组合物具有较长的固化寿命。环氧化合物（A）和具有特定结构的咪唑化合物（B）与固化剂混合物混合。此外，具有特定结构的咪唑化合物（B）和至少一种从包括多价酰胺化合物和多价羧酸酐的组中选出的交联剂（C）也混入固化剂混合物中。
• Hydrogen barrier agent, hydrogen barrier film forming composition, hydrogen barrier film, method for producing hydrogen barrier film, and electronic element
  申请人：TOKYO OHKA KOGYO CO., LTD.

  公开号：US10023540B2

  公开（公告）日：2018-07-17

  To provide a hydrogen barrier agent capable of imparting hydrogen barrier performance to various materials; a hydrogen barrier film forming composition including the hydrogen barrier agent; a hydrogen barrier film including the hydrogen barrier agent; a method for producing a hydrogen barrier film, which uses the hydrogen barrier film forming composition; and an electronic element provided with the hydrogen barrier film. A compound having a specific structure including an imidazolyl group is used as the hydrogen barrier agent. Furthermore, the hydrogen barrier film forming composition is prepared by blending the above-mentioned hydrogen barrier agent into the base material component. In addition, the hydrogen barrier film is formed using the hydrogen barrier film forming composition.

  提供一种能使各种材料具有氢阻隔性能的氢阻隔剂；一种包括该氢阻隔剂的氢阻隔薄膜形成组合物；一种包括该氢阻隔剂的氢阻隔薄膜；一种使用该氢阻隔薄膜形成组合物生产氢阻隔薄膜的方法；以及一种带有该氢阻隔薄膜的电子元件。氢阻隔剂使用了一种具有特定结构的化合物，其中包括咪唑基团。此外，氢阻隔膜形成组合物是通过将上述氢阻隔剂与基础材料成分混合而制备的。此外，使用氢阻隔膜形成组合物形成氢阻隔膜。
• Curable composition
  申请人：TOKYO OHKA KOGYO CO., LTD.

  公开号：US10239989B2

  公开（公告）日：2019-03-26

  A curable composition that can be cured at low temperature in a short time regardless of the type of epoxy compound that is mixed therewith, and has a long pot life; an adhesive comprising said curable composition; a method for producing a fiber-reinforced composite material that uses the curable composition; and a fiber-reinforced composite material containing a matrix comprising the curable composition. A curing agent mixture composition that can be cured at low temperature and in a short time, and provides the curable composition with a long pot life. An epoxy compound (A) and an imidazole compound (B) are blended in with the curable composition. In addition, the imidazole compound (B) and at least one type of crosslinking agent (C) are blended in with the curing agent mixture composition.

  一种可在短时间内低温固化的固化组合物，无论与之混合的环氧化合物类型如何，均具有较长的固化寿命；一种包含所述固化组合物的粘合剂；一种使用该固化组合物生产纤维增强复合材料的方法；以及一种含有包含该固化组合物的基体的纤维增强复合材料。一种固化剂混合物组合物，可在低温和短时间内固化，并使固化组合物具有较长的固化寿命。环氧化合物（A）和咪唑化合物（B）与可固化组合物混合。此外，咪唑化合物（B）和至少一种交联剂（C）也混入固化剂混合物中。
• Composition containing microparticles
  申请人：TOKYO OHKA KOGYO CO., LTD.

  公开号：US10570269B2

  公开（公告）日：2020-02-25

  A composition which contains microparticles and does not undergo the long-term process of aggregation of the microparticles during storage of the composition. An imidazole compound having a specific structure is added to a composition containing microparticles having a volume average particle diameter of 3000 nm or less. The composition may contain a base material component. The base material component may be a heat-curable or photocurable base material component. The microparticles may be inorganic particles and/or organic particles.

  一种含有微颗粒的组合物，在组合物储存期间不会经历微颗粒长期聚集的过程。将具有特定结构的咪唑化合物添加到含有体积平均粒径为 3000 nm 或更小的微颗粒的组合物中。该组合物可包含一种基础材料成分。基料成分可以是热固化或光固化基料成分。微颗粒可以是无机颗粒和/或有机颗粒。