N-(2-Hydroxyethyl)-N',N'-Dioctadecyl-1,3-Propanediamine | 37516-28-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(2-Hydroxyethyl)-N',N'-Dioctadecyl-1,3-Propanediamine
• 英文别名: 2-[3-(dioctadecylamino)propylamino]ethanol
• CAS: 37516-28-2
• 化学式: C₄₁H₈₆N₂O
• 分子量: 623.147
• InChiKey: GOYDDLXMASMNKP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  17.2
• 重原子数：
  44
• 可旋转键数：
  40
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  双十八烷基胺 在 potassium carbonate 作用下， 以 苯甲醇 为溶剂， 生成 N-(2-Hydroxyethyl)-N',N'-Dioctadecyl-1,3-Propanediamine
  参考文献：
  名称：

  Xylene-diamines as antiviral agents

  摘要：

  式##STR1##的化合物或其非毒性酸盐，其中R.sub.1是由1至20个碳原子组成的烷基；R.sub.2是由12至20个碳原子组成的烷基；R.sub.3选自由2至8个碳原子的氢和羟基烷基组成的群；R.sub.4选自由1至8个碳原子的氢、烷基和由2至8个碳原子组成的羟基烷基，这些化合物对于对抗脊椎动物的病毒感染是有用的。

  公开号：

  US04034040A1

文献信息

• Interferon induction in animals by amines
  申请人：Pfizer Inc.

  公开号：US04087552A1

  公开（公告）日：1978-05-02

  Combating viral infections in vertebrate animals by administering to the animals an amine selected from those having the formulae: ##STR1## and the non-toxic acid addition salts thereof wherein R.sub.1 is selected from the group consisting of alkyl of from 1 to 20 carbon atoms, aralkyl, aryloxyalkyl, hydroxyalkyl of from 2 to 8 carbon atoms and ##STR2## R.sub.2 is selected from the group consisting of alkyl of from 12 to 20 carbon atoms, aralkyl and aryloxyalkyl of from 12 to 24 carbon atoms and ##STR3## R.sup.o is alkoxy of from 1 to 18 carbon atoms; EACH OF R' and R" is selected from the group consisting of hydrogen, alkyl, alkoxy of from 1 to 18 carbon atoms; R' and R" when taken together are methylenedioxy; Provided that the total number of carbon atoms in R.sup.o, R' and R" is from 5 to 48; R.sub.3 is selected from the group consisting of hydrogen, alkyl of from 1 to 20 carbon atoms, hydroxyalkyl of from 2 to 8 carbon atoms, phenylcarbamoyloxy(lower alkyl), .omega.-carboxyalkanoyloxy(lower alkyl), allyl, alkanoyl of from 1 to 6 carbon atoms, alkanoyloxy(lower alkyl), carbo(lower alkoxy)lower alkyl, carboxy(lower alkyl), alkoxy(lower alkyl) and gem-di(lower alkoxy)lower alkyl; R.sub.4 is selected from the group consisting of hydrogen, alkyl of from 1 to 8 carbon atoms, hydroxyalkyl of from 2 to 8 carbon atoms, carbo(lower alkoxy)lower alkyl, alkanoyloxy(lower alkyl), carboxy(lower alkyl), alkoxy(lower alkyl), phenyl-carbamoyloxy(lower alkyl), .omega.-carboxyalkanoyloxy(lower alkyl), allyl, dihydroxyalkyl of from 3 to 8 carbon atoms, and morpholinoethyl; with the proviso that no more than two of the R variables are hydroxyalkyl; R.sub.3 and R.sub.4 when taken together with the nitrogen to which they are attached are morpholino; X is selected from the group consisting of straight chain alkylene of from 2 to 6 carbon atoms and ##STR4## X' is selected from the group consisting of X, phenylenedimethylene and ##STR5## m is 0 or 1, with the provisos that only one of X and X'is ##STR6## and when X' is phenylenedimethylene, m is 0; Y is selected from the group consisting of straight chain alkylene of from 2 to 8 carbon atoms and phenylenedimethylene; A is selected from the group consisting of hydrogen, cyano, hydroxy, alkoxy of from 1 to 20 carbon atoms, alkanoyloxy of from 2 to 20 carbon atoms, phenylcarbamoyloxy, chloro, bromo, .omega.-carboxyalkanoyloxy(lower alkyl), alkanoyloxy of from 1 to 6 carbon atoms, carbo(lower alkoxy) and alkanoylthio of from 2 to 20 carbon atoms and alkylthio of from 1 to 20 carbon atoms; R.sub.5 is selected from the group consisting of hydrogen, alkyl of from 1 to 20 carbon atoms, hydroxyalkyl of from 2 to 8 carbon atoms, (lower alkoxy)lower alkyl and ##STR7## R.sub.6 is selected from the group consisting of hydrogen, alkyl of from 12 to 20 carbon atoms, hydroxyalkyl of from 2 to 8 carbon atoms, (lower alkoxy)lower alkyl and ##STR8## R.sub.7 is selected from the group consisting of alkyl of from 12 to 20 carbon atoms and ##STR9## R.sub.8 is selected from the group consisting of alkyl of from 1 to 20 carbon atoms and ##STR10## each of p and n is 0 or an integer from 1 to 6, with the proviso that the sum of p and n is no greater than 6; and Z is selected from the group consisting of .omega.-carboxy(lower alkyl), morpholino, piperidino, piperazino, N-(.omega.-hydroxy lower alkyl)piperazino and N-(lower alkyl)piperazino.

  通过向脊椎动物内部注射选择自以下具有以下式的胺类化合物或其无毒酸加成盐的方法来对抗脊椎动物中的病毒感染：其中R1选自由1至20个碳原子的烷基，芳基烷基，芳氧基烷基，由2至8个碳原子的羟基烷基和-（CH2）n-（CH2）p-的组成; R2选自由12至20个碳原子的烷基，芳基烷基和芳氧基烷基组成; R0是由1至18个碳原子的烷氧基组成; 每个R'和R"选自氢，烷基，由1至18个碳原子的烷氧基;当R'和R"一起取时，它们是亚甲二氧基; 前提是R0，R'和R"中碳原子的总数为5至48; R3选自氢，由1至20个碳原子的烷基，由2至8个碳原子的羟基烷基，苯基氨基羧酸酯（低烷基），ω-羧基烷酰氧（低烷基），烯丙基，由1至6个碳原子的烷酰基，烷酰氧（低烷基），羧基（低烷基），烷氧（低烷基）和双（低烷氧基）烷基; R4选自氢，由1至8个碳原子的烷基，由2至8个碳原子的羟基烷基，羧基（低烷基），烷酰氧（低烷基），羧基（低烷基），烷氧（低烷基），苯基氨基羧酸酯（低烷基），ω-羧基烷酰氧（低烷基），烯丙基，由3至8个碳原子的二羟基烷基和吗啉基乙基; 前提是R变量中最多只有两个是羟基烷基; 当R3和R4与它们连接的氮一起取时，它们是吗啉; X选自由2至6个碳原子的直链烷基和-（CH2）n-的组成; X'选自X，苯二甲亚基和-（CH2）n-的组成; m为0或1，前提是X和X'中只有一个是-（CH2）n-，当X'是苯二甲亚基时，m为0; Y选自由2至8个碳原子的直链烷基和苯二甲亚基组成; A选自氢，氰基，羟基，由1至20个碳原子的烷氧基，由2至20个碳原子的烷酰氧基，苯基氨基羧酸酯，氯，溴，ω-羧基烷酰氧（低烷基），由1至6个碳原子的烷酰氧基，羧基（低烷氧基），由2至20个碳原子的烷酰硫基和由1至20个碳原子的烷硫基; R5选自氢，由1至20个碳原子的烷基，由2至8个碳原子的羟基烷基，（低烷氧基）烷基和-（CH2）n-的组成; R6选自氢，由12至20个碳原子的烷基，由2至8个碳原子的羟基烷基，（低烷氧基）烷基和-（CH2）n-的组成; R7选自由12至20个碳原子的烷基和-（CH2）n-的组成; R8选自由1至20个碳原子的烷基和-（CH2）n-的组成; p和n中的每一个都是0或1至6的整数，前提是p和n的总和不大于6; Z选自ω-羧基（低烷基），吗啉基，哌啶基，N-（ω-羟基低烷基）哌嗪和N-（低烷基）哌嗪的组成。
• US4034040A
  申请人：——

  公开号：US4034040A

  公开（公告）日：1977-07-05
• US4087552A
  申请人：——

  公开号：US4087552A

  公开（公告）日：1978-05-02
• US4258061A
  申请人：——

  公开号：US4258061A

  公开（公告）日：1981-03-24
• US4491583A
  申请人：——

  公开号：US4491583A

  公开（公告）日：1985-01-01