7-Chlorinden | 74124-87-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚和异茚
• 英文名称: 7-Chlorinden
• 英文别名: 4-chloroindene；4-Chloro-1H-indene
• CAS: 74124-87-1
• 化学式: C₉H₇Cl
• 分子量: 150.608
• InChiKey: JGBBOGMJBWWKHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  7-Chlorinden 、 1-萘硼酸 在 palladium diacetate potassium phosphate 作用下， 以 1,4-二氧六环 为溶剂， 反应 7.0h， 生成 4-(1-naphtyl)indene
  参考文献：
  名称：

  Metallocene compounds, processes for the production of olefin polymers using catalysts containing the compounds, and olefin polymers produced by the processes

  摘要：

  以下是用中文翻译的结果： 由下列一般式（1）表示的茂金属化合物： Y q KLMX 2 （1） 其中M、Y、q、L和X的定义如规范中所述。

  公开号：

  US20040127731A1

文献信息

• [EN] PROCESS FOR THE PREPARATION OF BREXPIPRAZOLE FROM 7-(4-CHLOROBUTOXY)QUINOLIN-2(1H)-ONE AND 1-(BENZO[B]THIOPHEN-4-YL)PIPERAZINE<br/>[FR] PROCÉDÉ POUR LA PRÉPARATION DE BREXPIPRAZOLE À PARTIR DE 7-(4-CHLOROBUTOXY)QUINOLIN-2(1H)-ONE ET DU 1-(BENZO[B]THIOPHEN-4-YL)PIPERAZINE
  申请人：JUBILANT GENERICS LTD

  公开号：WO2017216661A1

  公开（公告）日：2017-12-21

  The present invention relates to a process for the preparation of 7-4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy} quinolin-2(1H)-one (brexpiprazole) from 7-(4-chlorobutoxy)quinolin-2(1H)-one and 1-(benzo[b]thiophen-4-yl)piperazine. The intermediate 7-(4-chlorobutoxy)quinolin-2(1H)-one is prepared from 7-hydroxy-quinolin-2(1H)-one and 1-bromo-4-chloro-butane at a temperature below 45°C. The crude intermediate 7-(4-chlorobutoxy)quinolin-2(1H)-one is then treated with a resin (e.g. AMBER LITE IR 120 h) in an alcohol solvent (e.g. methanol) whereby the dimer impurity D is removed. The brexpiprazole obtained by this process is substantially free from dimer impurity D. Brexpiprazole is a D2 dopamine partial agonist called serotonin-dopamine activity modulator (SDAM) used for the treatment of schizophrenia and as an adjunct for major depressive disorder.

  本发明涉及一种从7-(4-氯丁氧基)喹啉-2(1H)-酮和1-(苯并噻吩-4-基)哌嗪制备7-4-[4-(1-苯并噻吩-4-基)哌嗪-1-基]丁氧基}喹啉-2(1H)-酮（布雷克匹普拉唑）的方法。中间体7-(4-氯丁氧基)喹啉-2(1H)-酮是由7-羟基喹啉-2(1H)-酮和1-溴-4-氯丁烷在低于45°C的温度下制备而成。然后，将粗制的中间体7-(4-氯丁氧基)喹啉-2(1H)-酮与树脂（例如AMBER LITE IR 120 h）在醇溶剂（例如甲醇）中处理，以去除二聚体杂质D。通过这种方法获得的布雷克匹普拉唑基本上不含二聚体杂质D。布雷克匹普拉唑是一种D2多巴胺部分激动剂，被称为血清素-多巴胺活性调节剂(SDAM)，用于治疗精神分裂症，并作为重性抑郁障碍的辅助治疗剂。
• Preparation of substituted indenes
  申请人：Schulte L. Jorg

  公开号：US20060052620A1

  公开（公告）日：2006-03-09

  The present invention relates to a simple process for preparing alkyl-substituted indenes of the formula (II) in improved yields from indenes of the formula (I) by reaction with compounds of the formula (III), to the alkyl-substituted indenes prepared in this way and to the use of these for the preparation of metallocenes for highly active polymerization catalysts.

  本发明涉及一种简单的方法，通过将化合物(III)与化合物(I)反应，改进产量地制备公式(II)的烷基取代的茚烯，以及通过这种方式制备的烷基取代的茚烯，并将其用于制备高活性聚合催化剂的金属茂。
• Novel Fluorinated Alkyl Fluorophosphoric Acid Salts of Onium and Ttransition Metal Complex
  申请人：Kimura Hideki

  公开号：US20070225458A1

  公开（公告）日：2007-09-27

  To obtain a polymerization initiator (acid generating agent) having excellent power for initiation of cationic polymerization without containing arsenic or antimony. [Means for solution] Provided is a specific onium salt or transition metal complex salt of a fluorinated alkyl fluorophosphoric acid.

  获取一种聚合引发剂（酸发生剂），具有优异的阳离子聚合引发能力，不含砷或锑。[解决方案的手段] 提供了一种特定的氟化烷基氟磷酸的烷基铵盐或过渡金属配合物盐。
• BIPYRIDINE COMPOUND, TRANSITION METAL COMPLEX, AND METHOD FOR PRODUCTION OF CONJUGATED AROMATIC COMPOUND USING THE TRANSITION METAL COMPLEX
  申请人：Asaumi Taku

  公开号：US20100184978A1

  公开（公告）日：2010-07-22

  A bipyridine compound represented by the formula (1): wherein R 1 , R 2 and R 3 each independently represent a C1-C10 alkyl group which may be substituted etc., and R 4 , R 5 , R 6 , R 7 and R 8 each independently represent a hydrogen atom etc., a transition metal complex obtained by contacting a bipyridine compound represented by the formula (1) with a compound of a transition metal belonging to Group 9, 10 or 11, and a method for production of a conjugated aromatic compound comprising reacting an aromatic compound (A) wherein one or two leaving groups are bonded to an aromatic ring with an aromatic compound (A) having the same structure as that of the above-mentioned aromatic compound (A) or an aromatic compound (B) being structurally different from the above-mentioned aromatic compound (A) and having one or two leaving groups bonded to an aromatic ring, in the presence of the transition metal complex.

  一种以式(1)表示的联吡啶化合物：其中R1、R2和R3各自独立地表示可以被取代的C1-C10烷基等，而R4、R5、R6、R7和R8各自独立地表示氢原子等，通过将式(1)表示的联吡啶化合物与属于9、10或11族过渡金属的化合物接触而获得的过渡金属配合物，以及一种制备共轭芳香化合物的方法，包括在过渡金属配合物的存在下，将一个或两个离去基团与芳环结合的芳香化合物（A）与具有与上述芳香化合物（A）相同结构的芳香化合物（A）或结构不同于上述芳香化合物（A）且具有一个或两个离去基团与芳环结合的芳香化合物（B）反应。
• METHOD FOR PRODUCING BIARYL COMPOUND
  申请人：Sato Koichi

  公开号：US20100087680A1

  公开（公告）日：2010-04-08

  A method for producing a biaryl compound, comprising reacting an aromatic organic compound with at least one compound selected from the group consisting of aromatic organoboron compounds and boroxine compounds, in the presence of a zero-valent nickel catalyst, phosphine ligand and base.

  一种制备双芳基化合物的方法，包括在零价镍催化剂、膦配体和碱的存在下，将芳香有机化合物与选自芳香基有机硼化合物和硼氧化物化合物组的至少一种化合物反应。