1-hydroxynonyl-1-phosphonic acid | 807322-41-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: 1-hydroxynonyl-1-phosphonic acid
• 英文别名: 9-Hydroxynonylphosphonic acid；9-hydroxynonylphosphonic acid
• CAS: 807322-41-4
• 化学式: C₉H₂₁O₄P
• 分子量: 224.237
• InChiKey: RCJWWTZHLXGYBB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  辛基膦酸 、 ziconium(IV) oxychloride octahydrate 、 1-hydroxynonyl-1-phosphonic acid 在 HF 作用下， 以 丙醇 、 水 为溶剂， 以99%的产率得到(zirconium (n-octylphosphonate)1.8 (9-hydroxynonyl-1-phosphonate)0.2)
  参考文献：
  名称：

  α-Zirconium phosphonates as new supports for metallocene catalysts

  摘要：

  Homoleptic and mixed alpha-zirconium phosphonates (ZrPs) alpha-Zr(O3PR)(2) (R = Me, Bu-n, Bu-i, Hex, Oct and Ph) and alpha-Zr(O3PR1)(2-x)(O3PR2)(x) were readily prepared in high yields from zirconyl choride and the corresponding phosphonic acids in suitable solvent mixtures under hydrothermal conditions at low fluoride concentrations. They form crystalline aggregates consisting of platelets from ca. 10-20 monolayers thickness, with well-defined surface structures. Impregnation with Cp2ZrCl2 by sublimation or slurry methods provided the first examples of ZrP-supported alkene polymerization catalysts. Crystal morphology and interlayer spacing are unaffected by the impregnation process. Solid-state NMR spectroscopy provides evidence for the integrity of the adsorbed metallocene structure. Covalent attachment of Cp*ZrCl3 to functionalized ZrPs of the type alpha-Zr(O3PR1)(1.8)(O3PCnH2nOH)(0.2) is similarly possible. The new catalysts polymerize ethene with good to excellent activities under mild conditions, even at remarkably low methylalumoxane/zirconocene ratios of 10: 1. The polymer is obtained as free-flowing particles, which reflect the morphology of the catalyst supports. (C) 2004 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcata.2004.06.011

文献信息

• Multilayer structure and method for producing same, coating liquid, packaging material, and protective sheet for electronic devices
  申请人：KURARAY CO., LTD.

  公开号：US11214696B2

  公开（公告）日：2022-01-04

  The present invention relates to a multilayer structure including a base (X) and a layer (Y), wherein the layer (Y) includes an aluminum-containing compound (A) and a phosphorus compound (BH) in which a phosphorus atom having at least one hydroxy group and a polar group are bonded via an alkylene chain having 3 to 20 carbon atoms or a polyoxyalkylene chain based on an alkylene having 3 to 20 carbon atoms, and the aluminum-containing compound (A) is a compound (Ab) including a reaction product (D) of an aluminum-containing metal oxide (Aa) and an inorganic phosphorus compound (BI).

  本发明涉及一种多层结构，包括基底（X）和层（Y），其中 层（Y）包括含铝化合物（A）和磷化合物（BH），其中具有至少一个羟基的磷原子和极性基团通过具有 3 至 20 个碳原子的亚烷基链或基于具有 3 至 20 个碳原子的亚烷基的聚氧亚烷基链键合，以及 含铝化合物 (A) 是一种化合物 (Ab)，包括含铝金属氧化物 (Aa) 和无机磷化合物 (BI) 的反应产物 (D)。
• MULTILAYER STRUCTURE, METHOD FOR PRODUCING SAME, COATING LIQUID, PACKAGING MATERIAL AND PROTECTION SHEET FOR ELECTRONIC DEVICES
  申请人：Kuraray Co., Ltd.

  公开号：EP3459730B1

  公开（公告）日：2022-05-11
• DRUG DELIVERY FROM IMPLANTS USING SELF-ASSEMBLED MONOLAYERS-THERAPEUTIC SAMS
  申请人：Agrawal C. Mauli

  公开号：US20090123516A1

  公开（公告）日：2009-05-14

  Disclosed are medical devices comprising one or more surfaces, one or more SAM molecules attached to the one or more surfaces of the medical device, and one or more therapeutic agents attached to the one or more self-assembled monolayer molecules. Also disclosed are medical devices comprising one or more surfaces, one or more self-assembled monolayer molecules attached to the one or more surfaces of the medical device, one or more linkers comprising a first functional group and a second functional group, the first functional group attached to the self-assembled monolayer molecule and a therapeutic agent attached to the second functional group. The therapeutic agent may be attached to the SAM molecule via a linker. The present invention also concerns methods of administering a therapeutic agent to a subject, comprising contacting the subject with one of the medical devices set forth herein.
• MULTILAYER STRUCTURE AND METHOD FOR PRODUCING SAME, COATING LIQUID, PACKAGING MATERIAL, AND PROTECTIVE SHEET FOR ELECTRONIC DEVICES
  申请人：KURARAY CO., LTD.

  公开号：US20190218403A1

  公开（公告）日：2019-07-18

  The present invention relates to a multilayer structure including a base (X) and a layer (Y), wherein the layer (Y) includes an aluminum-containing compound (A) and a phosphorus compound (BH) in which a phosphorus atom having at least one hydroxy group and a polar group are bonded via an alkylene chain having 3 to 20 carbon atoms or a polyoxyalkylene chain based on an alkylene having 3 to 20 carbon atoms, and the aluminum-containing compound (A) is a compound (Ab) including a reaction product (D) of an aluminum-containing metal oxide (Aa) and an inorganic phosphorus compound (BI).
• [EN] DRUG DELIVERY FROM IMPLANTS USING SELF-ASSEMBLED MONOLAYERS - THERAPEUTIC SAMS<br/>[FR] LIBERATION DE MEDICAMENTS PAR DES IMPLANTS COMPRENANT DES MONOCOUCHES AUTO-ASSEMBLEES (SAM) SAM THERAPEUTIQUES
  申请人：UNIV TEXAS

  公开号：WO2007019478A2

  公开（公告）日：2007-02-15

  [EN] Disclosed are medical devices comprising one or more surfaces, one or more SAM molecules attached to the one or more surfaces of the medical device, and one or more therapeutic agents attached to the one or more self-assembled monolayer molecules. Also disclosed are medical devices comprising one or more surfaces, one or more self-assembled monolayer molecules attached to the one or more surfaces of the medical device, one or more linkers comprising a first functional group and a second functional group, the first functional group attached to the self-assembled monolayer molecule and a therapeutic agent attached to the second functional group. The therapeutic agent may be attached to the SAM molecule via a linker. The present invention also concerns methods of administering a therapeutic agent to a subject, comprising contacting the subject with one of the medical devices set forth herein.
  [FR] L'invention concerne des dispositifs médicaux comprenant une ou plusieurs surfaces, une ou plusieurs molécules SAM attachées à une ou plusieurs surfaces du dispositif médical, et un ou plusieurs agents thérapeutiques fixés sur les molécules de la ou des monocouches auto-assemblées. L'invention concerne en outre des dispositifs médicaux comprenant une ou plusieurs surfaces, une ou plusieurs molécules de monocouche auto-assemblée fixées à la surface ou aux surfaces du dispositif médical, un ou plusieurs lieurs comprenant un premier groupe fonctionnel et un second groupe fonctionnel, le premier groupe fonctionnel étant attaché à la molécule de la monocouche auto-assemblée, et un agent thérapeutique attaché au second groupe fonctionnel. L'agent thérapeutique peut être fixé sur la molécule SAMS par l'intermédiaire d'un lieur. L'invention porte également sur des procédés d'administration d'un agent thérapeutique à un sujet consistant appliquer un dispositif médical du type décrit à un sujet.