((E)-1-(methoxymethoxy)-3-(4-(methoxymethoxy)styryl)-5-(prop-2-ynyloxy)benzene) | 1392500-14-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: ((E)-1-(methoxymethoxy)-3-(4-(methoxymethoxy)styryl)-5-(prop-2-ynyloxy)benzene)
• 英文别名: 1-(methoxymethoxy)-3-[(E)-2-[4-(methoxymethoxy)phenyl]ethenyl]-5-prop-2-ynoxybenzene
• CAS: 1392500-14-9
• 化学式: C₂₁H₂₂O₅
• 分子量: 354.403
• InChiKey: MUCNFXOISROTHJ-AATRIKPKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  26
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  46.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-叠氮基-1,3-双[(2,2-二甲基-1,3-二恶烷-5-基)氧代]丙烷 、 ((E)-1-(methoxymethoxy)-3-(4-(methoxymethoxy)styryl)-5-(prop-2-ynyloxy)benzene) 在 甲醇 、 copper(l) iodide 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 135.0h， 生成 (E)-2,2'-(2-(4-((3-hydroxy-5-(4-hydroxystyryl)phenoxy)methyl)-1H-1,2,3-triazol-1-yl)propane-1,3-diyl)bis(oxy)dipropane-1,3-diol
  参考文献：
  名称：

  Synthesis and evaluation of water-soluble resveratrol and piceatannol via BGLation

  摘要：

  Synthesis of four water-soluble resveratrol and piceatannol derivatives bearing symmetrically branched glyceryl trimer (BGL003) with a non-biocleavable linkage, and their biological evaluation as a mitochondrial fusion-inducing agent with cellular fat-reducing effect from cells, is described. The effect of Piceatannol-BGL003 conjugate was as high as that of original stilbenoids. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.06.019
• 作为产物：
  描述：

  1-(bromomethyl)-3-(methoxymethoxy)-5-(prop-2-ynyloxy)benzene 在 sodium hydride 作用下， 以 四氢呋喃 、 mineral oil 为溶剂， 反应 18.17h， 生成 ((E)-1-(methoxymethoxy)-3-(4-(methoxymethoxy)styryl)-5-(prop-2-ynyloxy)benzene)
  参考文献：
  名称：

  Synthesis and evaluation of water-soluble resveratrol and piceatannol via BGLation

  摘要：

  Synthesis of four water-soluble resveratrol and piceatannol derivatives bearing symmetrically branched glyceryl trimer (BGL003) with a non-biocleavable linkage, and their biological evaluation as a mitochondrial fusion-inducing agent with cellular fat-reducing effect from cells, is described. The effect of Piceatannol-BGL003 conjugate was as high as that of original stilbenoids. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.06.019

文献信息

• Synthesis and evaluation of water-soluble resveratrol and piceatannol via BGLation
  作者：Hisao Nemoto、Ayato Katagiri、Masaki Kamiya、Tsuyoshi Matsushita、Hatsuhiko Hattori、Kosuke Matsumura、Tomohiro Itou、Tomoyuki Kawamura、Toshiyuki Kita、Hana Nishida、Naokatu Arakaki

  DOI：10.1016/j.bmcl.2012.06.019

  日期：2012.8

  Synthesis of four water-soluble resveratrol and piceatannol derivatives bearing symmetrically branched glyceryl trimer (BGL003) with a non-biocleavable linkage, and their biological evaluation as a mitochondrial fusion-inducing agent with cellular fat-reducing effect from cells, is described. The effect of Piceatannol-BGL003 conjugate was as high as that of original stilbenoids. (C) 2012 Elsevier Ltd. All rights reserved.