1-benzyl-6-(4-bromophenyl)piperazine-2,5-dione | 1296672-75-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-benzyl-6-(4-bromophenyl)piperazine-2,5-dione
• 英文别名: 1-Benzyl-6-(4-bromophenyl)piperazine-2,5-dione
• CAS: 1296672-75-7
• 化学式: C₁₇H₁₅BrN₂O₂
• 分子量: 359.222
• InChiKey: GTJOHVLOEIUILN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-benzyl-6-(4-bromophenyl)piperazine-2,5-dione 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以80%的产率得到1-benzyl-2-(4-bromo-phenyl)-piperazine
  参考文献：
  名称：

  A facile and rapid synthesis of N-benzyl-2-substituted piperazines

  摘要：

  A facile and rapid synthetic approach of N-benzyl-2-substituted piperazine building-blocks via an Ugi strategy is described. This strategy is high yielding (80-92% overall yield), step-efficient and fast using microwave heating and tert-butylisocyanide as a convertible isocyanide. This method is useful for the obtention of key intermediates in medicinal chemistry. (c) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.02.011
• 作为产物：
  描述：

  ((benzyl-[(4-bromo-phenyl)-tert-butylcarbamoyl-methyl]-carbamoyl)-methyl)-carbamic acid tert-butyl ester 在 溶剂黄146 作用下， 反应 0.17h， 以95%的产率得到1-benzyl-6-(4-bromophenyl)piperazine-2,5-dione
  参考文献：
  名称：

  A facile and rapid synthesis of N-benzyl-2-substituted piperazines

  摘要：

  A facile and rapid synthetic approach of N-benzyl-2-substituted piperazine building-blocks via an Ugi strategy is described. This strategy is high yielding (80-92% overall yield), step-efficient and fast using microwave heating and tert-butylisocyanide as a convertible isocyanide. This method is useful for the obtention of key intermediates in medicinal chemistry. (c) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.02.011

文献信息

• Synthesis of 2,5-Diketopiperazine Derivatives Using 2-Isocyanophenyl 4-Methylbenzoate as a Fragrant Convertible Isocyanide
  作者：Fei Ji、Wen-Bin Yi、Chun Cai

  DOI：10.1002/jhet.1684

  日期：2014.9

  new protocol in which 2‐isocyanophenyl 4‐methylbenzoate is used as a convertible isocyanide for Ugi/deprotection + activation/cyclization synthesis of 2,5‐diketopiperazine derivatives has been developed. This operational simple procedure displays good functional group tolerance and avoids treatment of typically known offensive isocyanides.

  已开发出一种新的方案，其中2-异氰基苯基4-甲基苯甲酸酯用作2,5-二酮哌嗪衍生物的Ugi /去保护+活化/环化合成的可转换异氰酸酯。这种操作简单的程序显示出良好的官能团耐受性，并且避免了通常已知的令人讨厌的异氰酸酯的处理。
• A facile and rapid synthesis of N-benzyl-2-substituted piperazines
  作者：Mouhamad Jida、Mohamad Soueidan、Nicolas Willand、Francine Agbossou-Niedercorn、Lydie Pelinski、Guillaume Laconde、Rebecca Deprez-Poulain、Benoit Deprez

  DOI：10.1016/j.tetlet.2011.02.011

  日期：2011.4

  A facile and rapid synthetic approach of N-benzyl-2-substituted piperazine building-blocks via an Ugi strategy is described. This strategy is high yielding (80-92% overall yield), step-efficient and fast using microwave heating and tert-butylisocyanide as a convertible isocyanide. This method is useful for the obtention of key intermediates in medicinal chemistry. (c) 2011 Elsevier Ltd. All rights reserved.