2-Ethylsulfanyl-4-naphthalen-1-yl-6-oxo-1,4,5,6-tetrahydro-pyridine-3-carbonitrile

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-Ethylsulfanyl-4-naphthalen-1-yl-6-oxo-1,4,5,6-tetrahydro-pyridine-3-carbonitrile
• 英文别名: 6-ethylsulfanyl-4-naphthalen-1-yl-2-oxo-3,4-dihydro-1H-pyridine-5-carbonitrile
• 化学式: C₁₈H₁₆N₂OS
• 分子量: 308.404
• InChiKey: BLBMLKJKTCIPQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  78.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  碘乙烷 、 N-methylmorpholinium 5-cyano-4-(1-naphthyl)-2-oxo-1,2,3,4-tetrahydropyridine-6-thiolate 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.5h， 以88%的产率得到2-Ethylsulfanyl-4-naphthalen-1-yl-6-oxo-1,4,5,6-tetrahydro-pyridine-3-carbonitrile
  参考文献：
  名称：

  A new method for the synthesis ofN-methylmorpholinium 4-aryl-5-cyano-2-oxo-1,2,3,4-tetrahydropyridine-6-thiolates and their properties

  摘要：

  N-Methylmorpholinium 4-aryl-5-cyano-2-oxo-1,2,3,4-tetrahydropyridine-6-thiolates were obtained by the condensation of aromatic aldehydes, cyanothioacetamide, and Meldrum's acid in the presence of N-methylmorpholine. They were then used in the syntheses of substituted 6-alkylthio-3,4-dihydropyridin-2(1H)-ones and 4,5-dihydrothieno[2,3-b]pyridin-6(7H)-ones.

  DOI：

  10.1007/bf02495131

文献信息

• A new method for the synthesis ofN-methylmorpholinium 4-aryl-5-cyano-2-oxo-1,2,3,4-tetrahydropyridine-6-thiolates and their properties
  作者：V. D. Dyachenko、S. G. Krivokolysko、V. P. Litvinov

  DOI：10.1007/bf02495131

  日期：1997.10

  N-Methylmorpholinium 4-aryl-5-cyano-2-oxo-1,2,3,4-tetrahydropyridine-6-thiolates were obtained by the condensation of aromatic aldehydes, cyanothioacetamide, and Meldrum's acid in the presence of N-methylmorpholine. They were then used in the syntheses of substituted 6-alkylthio-3,4-dihydropyridin-2(1H)-ones and 4,5-dihydrothieno[2,3-b]pyridin-6(7H)-ones.