bis(N-ethylbenzylaminethiocarbonyl)disulfide | 35026-89-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: bis(N-ethylbenzylaminethiocarbonyl)disulfide
• 英文别名: [benzyl(ethyl)carbamothioyl]sulfanyl N-benzyl-N-ethylcarbamodithioate
• CAS: 35026-89-2
• 化学式: C₂₀H₂₄N₂S₄
• 分子量: 420.688
• InChiKey: LHVXHXIGDKZIBU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  121
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  potassium N-(benzyl)-N-(ethyl)dithiocarbamate 在 盐酸 、 sodium nitrite 作用下， 以 甲醇 、 水 为溶剂， 生成 bis(N-ethylbenzylaminethiocarbonyl)disulfide
  参考文献：
  名称：

  Bis(dialkylaminethiocarbonyl)disulfides as Potent and Selective Monoglyceride Lipase Inhibitors

  摘要：

  Monoglyceride lipase (MGL) inhibition may offer an approach in treating diseases in which higher 2-arachidonoyglycerol activity would be beneficial. We report here the synthesis and pharmacological evaluation of bis(dialkylaminethiocarbonyl)disulfide derivatives as irreversible MGL inhibitors. Inhibition occurs through interactions with MGL C208 and C242 residues, and these derivatives exhibit high inhibition selectivity over fatty acid amide hydrolase, another endocannabinoid-hydrolyzing enzyme.

  DOI：

  10.1021/jm901323s

文献信息

• Paul, R. C.; Shara, N. C.; Chauhan, R. K., Indian journal of chemistry, 1972, vol. 10, p. 227 - 230
  作者：Paul, R. C.、Shara, N. C.、Chauhan, R. K.、Parkash, R.

  DOI：——

  日期：——
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: C: MVol.D3, 6.2.5.6.7.12, page 239 - 239
  作者：

  DOI：——

  日期：——
• DISULFIRAM DERIVATIVES AS ALDH1A1 AND MAGL INHIBITORS
  申请人：BATTERJEE MEDICAL COLLEGE

  公开号：US20230174475A1

  公开（公告）日：2023-06-08

  A disulfiram derivative of formula (I) wherein R 1 and R 2 are independently —CH 2 CH 2 COOH, —CH 2 CH 2 COOEt, optionally substituted methylenepyridyl, optionally substituted methylenefuranyl, or optionally substituted methylenethiopenyl, may be useful in aldehyde dehydrogenase 1 a 1 (ALDH 1 a 1 ) and/or monoacylglycerol lipase (MAGL)-mediated diseases or disorders. Such derivatives may avoid or limit aldehyde dehydrogenase 2 (ALDH2) and/or fatty acid amide hydrolase (FAAH) antagonism.
• Bis(dialkylaminethiocarbonyl)disulfides as Potent and Selective Monoglyceride Lipase Inhibitors
  作者：Coco N. Kapanda、Giulio G. Muccioli、Geoffray Labar、Jacques H. Poupaert、Didier M. Lambert

  DOI：10.1021/jm901323s

  日期：2009.11.26

  Monoglyceride lipase (MGL) inhibition may offer an approach in treating diseases in which higher 2-arachidonoyglycerol activity would be beneficial. We report here the synthesis and pharmacological evaluation of bis(dialkylaminethiocarbonyl)disulfide derivatives as irreversible MGL inhibitors. Inhibition occurs through interactions with MGL C208 and C242 residues, and these derivatives exhibit high inhibition selectivity over fatty acid amide hydrolase, another endocannabinoid-hydrolyzing enzyme.