N-丁基乙烷亚胺 | 6898-74-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N-丁基乙烷亚胺
• 英文名称: Acetaldehyd-butylimin
• 英文别名: ethylidene-butyl-amine；Aethyliden-butyl-amin；ethylidene n-butylamine；Acetaldehyd-n-butylimid；N-Aethyliden-butylamin；N-n-Butylmethylaldimin；1-Butanamine, N-ethylidene-；N-butylethanimine
• CAS: 6898-74-4
• 化学式: C₆H₁₃N
• 分子量: 99.1759
• InChiKey: NKGJJLDEORZFKJ-UHFFFAOYSA-N

物化性质

• 沸点：
  98-106 °C
• 密度：
  0.7513 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  7
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  12.4
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2921199090

反应信息

• 作为反应物：
  描述：

  N-丁基乙烷亚胺 在 乙醇 、 铂 作用下， 生成 N-乙基正丁胺
  参考文献：
  名称：

  Long-term comparison between perindopril and nifedipine in normotensive patients with type 1 diabetes and microalbuminuria

  摘要：

  The aim of this study is to compare the efficacy of an angiotensin-converting enzyme inhibitor with a dihydropyridine calcium channel blocker in preventing progression to macroalbuminuria and/or a decline in renal function in normotensive patients with type 1 diabetes and microalbuminuria. Forty-two patients were randomized to treatment with either perindopril, slow-release nifedipine, or placebo. In the first 3 months, drug dosage was titrated to achieve a decrease in diastolic blood pressure of at least 5 mm Hg. Thirty-three patients had a minimum of 24 months' data, and 25 patients were followed up beyond 36 months (mean, 67 +/- 4 months). Patients were studied every 3 months and at the end of the treatment period; those who remained normotensive discontinued therapy and were followed up for an additional 3 months. Baseline geometric mean albumin excretion rates (AERs) were as follows: perindopril, 66 mug/min; nifedipine, 59 mug/min; and placebo, 66 mug/min. During the first 3 years, 7 of the perindopril-treated but none of the placebo or nifedipine-treated patients reverted to normoalbuminuria (P < 0.01). Median AERs at 3 years of treatment in each group were 23 g/min for perindopril, 122 mug/min for nifedipine, and 112 mug/min for placebo patients (P < 0.01). in patients with more than 3 years' follow-up, median AERs decreased by 45% in the first year and then stabilized in the perindopril group, but increased by 17.6% in the nifedipine group and 27.6% in the placebo group (P < 0.03) in the first year, then increased progressively. In these same patients, there was a significant decline in glomerular filtration rate in the nifedipine group (-7.8 +/- 1.8 mL/min/1.73 m(2)/y), but not in the other two groups (perindopril, -1.0 +/- 1.2 mL/min/1.73 m(2)/y; placebo, -1.3 +/- 1.1 mL/min/1.73 m(2)/y; P = 0.004). At the end or the study, cessation of treatment for 3 months was associated with a doubling of AERs in the perindopril-treated group, but no change in the other two groups (P < 0.001). In conclusion, long-term perindopril therapy is more effective than nifedipine or placebo in delaying the progression of diabetic nephropathy and reducing AER to the normoalbuminuric range (<20 mug/min) in normotensive patients with type I diabetes and microalbuminuria. (C) 2000 by the National Kidney Foundation, Inc.

  DOI：

  10.1016/s0272-6386(05)80003-4
• 作为产物：
  描述：

  正丁胺 、 乙炔 在 zinc diacetate 、 cadmium(II) acetate 作用下， 120.0 ℃ 、1.47 MPa 条件下， 生成 N-丁基乙烷亚胺
  参考文献：
  名称：

  Reppe et al., Justus Liebigs Annalen der Chemie, 1956, vol. 601, p. 81,104

  摘要：

  DOI：

文献信息

• Dehydrogenative Coupling of Ethanol and Ester Hydrogenation Catalyzed by Pincer-Type YNP Complexes
  作者：Dmitry G. Gusev

  DOI：10.1021/acscatal.6b02324

  日期：2016.10.7

  The “Y” donor group (Y = −OMe, −SEt, −PPh2, −NH2, −NMe2, −Py, pyrrolidinyl, quinolyl) of the pincer-type ruthenium complexes RuHCl(CO)[κ3-YNP] has a dramatic influence on the catalytic activity in the dehydrogenative homocoupling and cross-coupling of ethanol and ester hydrogenation reactions. The observations are connected with the mechanisms of the catalytic reactions, and this paper provides evidence

  该“Y”给体基团（Y = -OMe，-set，-PPh 2，-NH 2，-NMe 2钳型钌，-py，吡咯烷基，喹啉基）络合物RuHCl（CO）[κ 3 -YNP对乙醇的脱氢均偶联和交叉偶联以及酯加氢反应中的催化活性具有显着影响。这些观察结果与催化反应的机理有关，并且本文为双官能催化剂以外球方式辅助酯C–O键形成/裂解提供了证据，这让人联想到蒂申科化学。
• Synthesis of imines from amines in aliphatic alcohols on Pd/ZrO₂catalyst under ambient conditions
  作者：Wenjing Cui、Bao Zhaorigetu、Meilin Jia、Wulan Ao、Huaiyong Zhu

  DOI：10.1039/c3ra44625e

  日期：——

  Synthesis of imines from amines and aliphatic alcohols (C1–C6) in the presence of base on supported palladium nanoparticles has been achieved for the first time. The catalytic system shows high activity and selectivity in open air at room temperature.

  首次实现了在负载型钯纳米颗粒上存在碱的情况下，由胺和脂族醇（C 1 -C 6）合成亚胺的方法。该催化体系在室温下在露天中表现出高活性和选择性。
• 1,2,4-Triazine und kondensierte derivate—XII
  作者：G. Doleschall、K. Lempert

  DOI：10.1016/0040-4020(73)85008-2

  日期：1973.1

  3-Alkylthio-6-(2-aminophenyl)-1,2,4-triazin-5(2H)-ones (1) react with oxo compounds, the corresponding Schiff bases, as well as with methyl propionate to yield tricyclic products of type 8. The potential tautomeric equilibrium between compounds 8 and the corresponding Schiff bases 6 could not be demonstrated by spectroscopic means. The 1:1 adduct obtained with acetylacetone exists in solution as a

  3-烷硫基-6-（2-氨基苯基）-1,2,4-三嗪-5（2H）-1（1）与含氧化合物，相应的席夫碱以及丙酸甲酯反应生成三环产物类型8。化合物之间的潜在互变异构平衡8和相应的席夫碱6可以不通过光谱方法来证明。用乙酰丙酮获得的1：1加合物以8r和互变异构烯胺5的混合物形式存在于溶液中，而在结晶状态下仅存在纯烯胺5。1A与原酸酯反应生成更高的不饱和类似物21之8。讨论了制备化合物8和21的几种其他方法，其光谱以及它们的反应。
• Bast,K. et al., Chemische Berichte, 1972, vol. 105, p. 2825 - 2840
  作者：Bast,K. et al.

  DOI：——

  日期：——
• Reaction of O-substituted hydroxylamines with aldimines and primary aliphatic amines in the synthesis of diaziridines
  作者：N. N. Makhova、V. Yu. Petukhova、L. I. Khmel'nitskii

  DOI：10.1007/bf00950653

  日期：1982.10